CAS: 1619-62-1; Diethyl 2,2-Dimethylmalonate

该化合物是一种恶性酯衍生物,广泛用作有机合成的多功能中间体,其结构结构有两种酯类和两种甲基替代物,其核心碳,增强了其在授粉,凝聚和迈克尔附加反应中的回作用;该化合物在制药和农用化学应用中特别宝贵,用于制造复杂的分子,包括活性药物成分和精细化学品;在标准条件下,其高纯度和稳定性确保合成工艺的一贯性能;此外,电排酯组有助于脱氧,使其成为核循环替代和碳-碳联结反应的有用前体.

结构式图片

相似化合物

126-30-7 14002-80-3 4835-90-9

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

diethyl ether 3-methyl-hexane-2,2,4-tricarboxylic acid triethyl ester sodium ethanolate dimethyl-malonyl bromidepentan-3-one isobutyric Acid 3-hydroxy-2,2,3-trimethylbutanoic acid 2,5-dimethylhexan-3-one

合成工艺路线路线简述

    2,2-Bis(Ethoxycarbonyl)-1-Bromopropane置于碘化铵,铜,锌体系中,用 甲醇 用作溶剂,以100%的收率获得二甲基丙二酸二乙酯
    参考文献:与辅酶 B12 依赖性重排相关的自由基中的 1,2-迁移
    标题:与辅酶 B12 依赖性重排相关的自由基中的 1,2-迁移
    摘要:Les Radicaux Libres Xc(Ch 3 )(Coor)Ch 2 •,Ou X=c(=0)Me,C(=o)Set,C(=0)Oet,C(=ch 2 )Me,Et C 6 H 5,Sont Generes Par Reaction Des Bromures对应物avec (N-Bu) 3 Snh.Etude De La Reaction De Migration-1,2 De X Pour Form Les Radicaux • C(Ch 3 )(Coor)(Ch 2 X)
    Doi:10.1021/ja00218A020

    海关参考信息

    专利信息


    专利号:US-6448412-B1
    优先权日:1995-07-31
    标题:Methods for the preparation and characterization of multi-substituted fullerenes
    发明人:MURPHY RANDALL B; WILSON STEPHEN R; LU QUING
    权利人:SPHERE BIOSYSTEMS INC
    摘要:The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the C n fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3 He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.

    专利号:WO-03070714-A1
    优先权日:2002-02-20
    标题 :Fluorous acetylation
    发明人:READ ROGER
    权利人:UNISEARCH LTD; READ ROGER
    摘要:The present invention relates to a method for the synthesis of highly fluorinated compounds and to novel highly fluorinated compounds. In particular, the present invention relates to the synthesis of highly fluorinated acetals and ketals and their thio analogues and to novel highly fluorinated acetals and ketals and their thio analogues.

    专利号:WO-2004076425-A1
    优先权日:2003-02-21
    标题:Improved synthesis of macrocyclic tetraamido compounds and new metal insertion process

    专利号:US-7737166-B2
    优先权日:2005-08-17
    标 题:Antifungal bicyclic hetero ring compounds
    发明人:KAWAKAMI KATSUHIRO; KANAI KAZUO; HORIUCHI TAKAO; TAKESHITA HIROSHI; KOBAYASHI SYOZO; SUGIMOTO YUICHI; ACHIWA ISSEI; KUROYANAGI JUNICHI
    权利人:DAIICHI SANKYO CO LTD
    摘要:A 1,6-β-glucan synthetase inhibitor is provided, having potent growth inhibition and having excellent safety. A compound is provided, capable of expressing in a wide spectral range and specifically or selectively, an antifungal effect based on its functional mechanism of 1,6-β-glucan synthesis inhibition. Also provided is a drug, a salt or hydrate thereof, especially an antifungal that contains the compound. Concretely, provided is a compound of the following formula (I), its salt or hydrate, and a drug or antifungal containing, as the active ingredient, the compound, its salt or hydrate:

    专利号:US-2007191395-A1
    优先权日:2004-02-16
    标题 :Heterocyclic compounds having antifungal activity
    发明人:KAWAKAMI KATSUHIRO; KANAI KAZUO; FUJISAWA TETSUNORI; MORITA CHIKANORI; SUZUKI TAKASHI
    权利人:KAWAKAMI KATSUHIRO; KANAI KAZUO; FUJISAWA TETSUNORI; MORITA CHIKANORI; SUZUKI TAKASHI
    摘要:A compound which can specifically or selectively expresses an antifungal activity with a broad spectrum, based on the functional mechanism of 1,6-β-glucan synthesis inhibition, is provided, and an antifungal agent which comprises such a compound, a salt thereof or a solvate thereof is provided. A compound represented by the following formula (I), a salt thereof or a solvate thereof.
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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Jończyk, A.; Kowalkowska, A., Science of Synthesis, (2006) 8, 1014.
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