CAS: 1708-32-3; 2,5-Dihydrothiophene

相似化合物

3354-32-3 67488-46-4 113772-16-0

上下游产品

thiophene 1,4-dithiane-2,5-diol vinyltriphenylphosphonium bromide 3-buten-1-yne thiophene 3-Sulfolene trans-3,4-dihydroxytetrahydrothiophene-1,1-dioxide 1-phenacyl-2,5-dihydrothiophenium bromide

乙烯基乙炔置于sodium Hydrogensulfide,水体系中,用 二甲基亚砜 用作溶剂,化学反应 4.0H,以97.8%的收率获得2,5-二氢噻吩
参考文献:黑社会的反应硒8 kohdmso,Se 8 kohdmso,Tekohhmpa与炔
标题:黑社会的反应硒8 kohdmso,Se 8 kohdmso,Tekohhmpa与炔
摘要:已经开发了使用超碱性介质进行乙炔阴离子转化的新的通用方法.它允许在常规条件下乙炔不会发生的一系列新反应.的三单元组硒8 kohdimethylsulfoxide(dmso),硒8提出了kohdmso,Tekoh-六甲基磷酸三酰胺(hmpa)作为制备硫,硒和碲不饱和化合物的新型有效试剂.发现乙炔与硫,硒和碲的一系列反应在dmso或hmpa中,在碱和水在80-120°的温度下进行,导致二乙烯基硫化物,二乙烯基硒化物和二乙烯基碲化物的收率为25-80%.通过乙酸乙烯酯与硫的反应获得了噻吩,二-1-(1,3-丁二烯基)硫醚,1-乙烯基-2-噻二环[3.2.0]庚-3-烯和二氢噻吩.乙烯基乙炔与硒的反应可得到硒烯,二-1-(1,3-丁二烯基)硒化物,1-乙烯基-2-硒二环[3.2.0]庚-3-烯,甲基(1-(1,3-丁二烯基) )硫化物和甲基硫甲基1-(1,4-丁二烯基)硒化物,乙烯基1-(1
Doi:10.1016/0040-4020(82)80214-7

专利信息

专利号:WO-2013138200-A1
优先权日:2012-03-13
标 题 :Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof
发明人：FORTUNAK JOSEPH MARIAN; KULKARNI AMOL ANANT; KING CHRISTOPHER
权利人:UNIV HOWARD
摘要:Methods are provided for a green chemistry one-pot synthesis of amodiaquine and amodiaquine analogs. The methods have a lower environmental impact, lower investment cost, reduced amounts of byproducts and impurities, and a shorter synthesis time, compared to current conventional synthesis methods. The methods reduce the total number of steps in the synthesis from four to five down to two, thereby simplifying production; and allow a reduced number of solvents and reagents to be used in production, thereby reducing the waste generated in the synthesis. The methods can reduce the waste to about 3-5 kilograms of waste generated per kilogram of product produced; and surprisingly improve the overall yield from 60-65% to greater than 90% as compared to the current conventional synthesis methods for amodiaquine and its analogs.

专利号:US-2013184465-A1
优先权日:2010-09-30
标 题:Process for the synthesis of thio-triazolo-group containing compounds
发明人：DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL
权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE
摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.

专利号:US-8168745-B2
优先权日:2007-08-02
标 题:Process for the preparation of poly- and oligothiophenes on an industrial scale
发明人：HENNINGER BJOERN; RAUSCHER FRANK; MLECZKO LESLAW
权利人:HENNINGER BJOERN; RAUSCHER FRANK; MLECZKO LESLAW; BAYER TECHNOLOGY SERVICES GMBH
摘要:Process for industrial scale synthesis of poly- and oligothiophenes, which works in concentrated solution. In this process, a solution which comprises an organometallic thiophene reagent is added to a second solution which comprises a catalyst.

专利号:WO-03040139-A1
优先权日:2001-11-06
标 题:Diastereoselective process for the preparation of the antiviral agent4-amino-1-(2r-hydroxymethyl-[1,3]oxathiolan-5s-yl)-1h-pyrimidin-2-one
发明人：BOTTA MAURIZIO; CRESCENZI CRISTINA; MANCINETTI DANIELE; POMPEI MARCO; BONIFACIO FAUSTO
权利人:RECORDATI CHEM PHARM; BOTTA MAURIZIO; CRESCENZI CRISTINA; MANCINETTI DANIELE; POMPEI MARCO; BONIFACIO FAUSTO
摘要:Process for the synthesis of 4-amino-1-(2R-hydroxymethyl - [1,3]oxathiolan-5S-yl)-1H-pyrimidin-2-one (LAMIVUDINE) comprising the reduction of 2-(R)-(4'-(R)acetonyl)-5-oxo-1,3-oxathiolan to give 2-(R)-(4'-(R)-acetonyl)-5-hydroxy-1,3-oxathiolan.

专利号:US-4656289-A
优先权日:1984-10-25
标 题 :1,3-dibenzyl-4-halohexahydro-1H-thieno[3,4-d]imidazol-2(3H)-one intermediates
发明人：BATES HANS A; ROSENBLUM STUART
权利人:RES FOUNDATION OF STATE UNIV O
摘要:Novel synthetic routes to (3aα,6aα)-1,3-dibenzyl hexahydro-1H-thieno[3,4-d]imidazol-2(3H)-one 5,5-dioxide, a known intermediate in the synthesis of biotin are provided. n A novel synthetic route from this intermediate to biotin is also disclosed.

专利号:US-4466900-A
优先权日:1981-09-22
标 题:Process for the preparation of fluorescent brightener formulations which are stable on storage
发明人：HORLACHER PAUL; PFENNINGER HEINZ
权利人:CIBA GEIGY CORP
摘要:A process is described for the preparation of concentrated liquid formulations, stable on storage, of anionic fluorescent brighteners, which process consists in passing a crude (for example obtained from synthesis) aqueous solution or dispersion of a fluorescent brightener containing sulfo groups, in particular a stilbene fluorescent brightener belonging to the group comprising bistriazinylaminostilbenedisulfonic acids, bis-styrylbiphenyls, bis-styrylbenzenes and bis-triazolylstilbenedisulfonic acids, is passed through a semipermeable membrane which contains ionic groups and has a pore diameter of 1-500 ANGSTROM in order to remove salts and by-products from the synthesis having molecular weights below 500 and in order to remove part of the water. The resulting concentrated preparation can, if desired, be concentrated further and/or treated with formulation assistants and, if desired, further additives.