3-三氟甲基苯甲酸置于氯化亚砜体系中,用 甲醇,二氯甲烷,苯 用作溶剂,化学反应 5.0H,反应生成3-三氟甲基苯甲酸甲酯
参考文献:Antidepressant Activity Of 5-Aryl-2,3,5,6-Tetrahydroimidazo[2,1-A]Isoquinolin-5-Ols
标题:Antidepressant Activity Of 5-Aryl-2,3,5,6-Tetrahydroimidazo[2,1-A]Isoquinolin-5-Ols
摘要:A Series Of 5-Aryl-2,3,5,6-Tetrahydroimidazo[2,1-A]Isoquinolin-5-Ols Was Prepared And Evaluated For Potential Antidepressant Activity In The Reserpine-Induced Hypothermia Model And Selected Central Nervous System And Autonomic Activity Tests. Several Members Of The Series,Notably The 4-Chloro-And 4-Fluorophenyl Analogues,Demonstrated Pharmacological Activity In The Range Of Imipramine. Both Compounds Provided A Marked Potentiation Of The 5-Hydroxytryptophan-Facilitated Monosynaptic Spike In The Spinal Cat Preparation.
Doi:10.1021/jm00359A025