CAS: 29475-64-7; H-N-Me-D-Ala-Oh

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1142-20-7 15761-38-3 16948-16-6

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CAS号32644-15-8 2-溴丙酸 | CAS号74-89-5 氨基甲烷

在 Sodium Periodate,盐酸体系中,用 甲醇 用作溶剂,化学反应 22.0H,反应生成N-甲基-D-丙氨酸
参考文献:黄曲霉菌素a(一种由寄生曲霉产生的黄曲霉毒素的特异性抑制剂)的绝对构型.
标题:黄曲霉菌素a(一种由寄生曲霉产生的黄曲霉毒素的特异性抑制剂)的绝对构型.
摘要:Aflastatin A(1)是一种由寄生曲霉产生的黄曲霉毒素的特异性抑制剂.它具有带有长烷基侧链的四酸衍生物的新型结构.在这项研究中化学阐明了1个化合物中29个手性中心的绝对构型.首先,从1或其甲基醚(2)制备四个小片段分子,并将它们的绝对结构分配为n-甲基-D-丙氨酸,(2S,4R)-2,4-二甲基-1,6-己二醇二苯甲酸酯,(R)-3-羟基十二烷酸和(R)-1,1,2,4-丁三醇三苯甲酸酯.接下来,通过naio(4)氧化从1中获得具有13个手性中心的无环片段分子3,并通过基于j的构型分析阐明了其相对立体化学.通过分析(3)j(h,H)和(2,3)j(c,H)的耦合常数以及roe数据,验证了3的相对构型.最后,通过进一步的基于j的构型分析,使用由2个具有28个手性碳的片段分子7,澄清了1个烷基侧链中的所有相对构型.通过将这些相对构型与前四个片段分子的绝对构型联系起来,可以完全确定1的绝对立体化学.
Doi:10.1021/jo991284C

专利信息

专利号:US-10526379-B2
优先权日:2015-06-05
标题:Methods and products for fusion protein synthesis
发明人：HOWARTH MARK
权利人:UNIV OXFORD INNOVATION LTD
摘要:A method of producing a fusion protein is provided. The method includes: a) contacting a first protein with a second protein under conditions that enable the formation of an isopeptide bond between said proteins to form a linked protein; and b) contacting the linked protein from (a) with a third protein under conditions that enable the formation of an isopeptide bond between said third protein and said linked protein to form a fusion protein. Peptide linkers and the use of orthogonal pairs of said linkers in the synthesis of fusion proteins are also provided. Recombinant proteins comprising said linkers, nucleic acid molecules encoding said proteins and linkers, vectors comprising said nucleic acid molecules and host cells comprising said vectors and nucleic acid molecules are also contemplated.

专利号:WO-2008098280-A1
优先权日:2007-02-16
标题:Methods for the synthesis of dicarba bridges in growth hormone peptides
发明人：ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
权利人:POLYCHIP PHARMACEUTICALS PTY; UNIV MONASH; ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
摘要:The invention relates to peptides comprising the carboxy terminal sequence of a growth hormone or an analogue of such a peptide in which the disulfide bridge is replaced by a dicarba bridge. Compositions containing such dicarba bridged peptides and method of treating obesity in an animal such as a human comprising administration of such dicarba bridged peptides are also disclosed.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:US-8906848-B2
优先权日:2011-04-01
标 题 :Aureobasidin derivatives and methods of synthesis
发明人：WUTS PETER; ELHAMMER AKE P
权利人:WUTS PETER; ELHAMMER AKE P; AUREOGEN BIOSCIENCES INC
摘要:In general, the invention relates to methods of synthesizing AbA derivatives that are useful for treating infection and amenable to further chemical elaboration. These novel methods are scalable for industrial production and employ safer, simpler, and more efficient process conditions. Furthermore, the invention also provides novel compounds and intermediates useful for implementing the methods described herein and/or for the treatment of infection.

专利号:WO-9411388-A1
优先权日:1992-11-06
标题:Support for the synthesis of modular polymers

专利号:EP-4192512-A1
优先权日:2020-08-06
标题 :Methods for the synthesis of protein-drug conjugates