CAS: 624-41-9; 2-Methylbutyl Acetate

相似化合物

616-16-0 1565-80-6 624-41-9

上下游产品

CAS号137-32-6 2-甲基丁醇 | CAS号141-78-6 乙酸乙酯 | CAS号110-86-1 吡啶 | CAS号75-36-5 乙酰氯 | CAS号616-13-7 1-氯-2-甲基丁烷 | CAS号127-08-2 醋酸钾 | CAS号72-89-9 乙酰辅酶A | CAS号108-24-7 乙酸酐 | CAS号78-78-4 异戊烷 | CAS号1565-80-6 S(-)-2-甲基-1-丁醇 | CAS号513-35-9 2-甲基-2-丁烯 | CAS号563-46-2 2-甲基-1-丁烯 | CAS号67-64-1 丙酮

2-甲基丁烷置于溶剂黄146体系中,化学反应生成 2-甲基丁基乙酸酯
参考文献:Aschan,Chemisches Zentralblatt,1918,Vol. 89,# Ii,P. 939
标题:Aschan,Chemisches Zentralblatt,1918,Vol. 89,# Ii,P. 939

专利信息

专利号:US-6927291-B2
优先权日:2001-03-01
标 题:Method for the synthesis of 2′,3′-dideoxy-2′,3′-didehydronucleosides
发明人：JIN FUQIANG; CONFALONE PASQUALE N
权利人:PHARMASSET LTD
摘要:An efficient synthetic route to antiviral 2′,3′-dideoxy-2′,3′-didehydro-nucleosides, such as 2′,3′-dideoxy and 2′- or 3′-deoxyribo-nucleoside analogs, from available precursors is disclosed, with the option of introducing functionality as needed. In one embodiment, a method for the preparation of β-D and β-L-2′,3′-dideoxy-2′,3′-didehydro-nucleosides is described that includes: activating a compound of structure (1) n n nwherein B is a pyrimidine or purine base and Y is O, S or CH 2 with an acyl halide of the formula X—C(â•?O)R 1 , X—C(â•?O)C(R 1 ) 2 OC(â•?O)R 1 or X—C(â•?O)OR 1 (wherein X is a halogen, and each R 1 is independently hydrogen, lower alkyl, alkyl, aryl or phenyl); reducing the resulting compound with a reducing agent to form a 2′,3′-dideoxy-2′,3′-didehydro-nucleoside; and optionally deprotecting the nucleoside. The haloacylation of the first step can form the 2′-acyl-3′-halonucleoside, the 3′-acyl-2′-halonucleoside, or a mixture thereof.

专利号:CA-2439836-A1
优先权日:2001-03-01
标 题 :Method for the synthesis of 2',3'-dideoxy-2',3'-didehydronucleosides

专利号:US-2005250946-A1
优先权日:2001-03-01
标 题 :Method for the synthesis of 2',3'-dideoxy-2',3'-didehydronucleosides

专利号:CN-1505635-A
优先权日:2001-03-01
标题 :Method for the synthesis of 2',3'-dideoxy-2',3'-didehydronucleosides

专利号:US-2002198224-A1
优先权日:2001-03-01
标 题:Method for the synthesis of 2',3'-dideoxy-2',3'-didehydronucleosides

专利号:WO-02070533-A2
优先权日:2001-03-01
标题 :Method for the synthesis of 2',3'-dideoxy-2',3'-didehydronucleosides