24599-26-6 = 69-72-7 + 109507-30-4 + 861533-46-2 反应条件:1.1 Rt -> 500 °C 标题:Thermal Stability And Degradation Of (4-(Acrylamido)-2-Hydroxybenzoic Acid) Homopolymer And Copolymer Of 4-(Acrylamido)-2-Hydroxybenzoic Acid With Methyl Methacrylate 作者:Diab,M. A.; Et Al 参考文献:Synthesis And Reactivity In Inorganic 日期:2015 卷标:45(9) 页码:1439-1447]
65-49-6 + 814-68-6 = 69-72-7 + 109507-30-4 + 861533-46-2 反应条件:1.1 Solvents: Benzene; 0 °C2.1 Catalysts: Azobisisobutyronitrile Solvents: Dimethylformamide; 6 H,Reflux3.1 Rt -> 500 °C 标题:Thermal Stability And Degradation Of (4-(Acrylamido)-2-Hydroxybenzoic Acid) Homopolymer And Copolymer Of 4-(Acrylamido)-2-Hydroxybenzoic Acid With Methyl Methacrylate 作者:Diab,M. A.; Et Al 参考文献:Synthesis And Reactivity In Inorganic 日期:2015 卷标:45(9) 页码:1439-1447
水杨基羟肟酸置于盐酸体系中,用 1,4-二氧六环 作为反应溶剂,化学反应生成 水杨酸 参考文献:Ghosh,Kallol K.; Ghosh,Sharmistha; Thakur,Santosh S.,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1996,Vol. 35,# 2,P. 121-126 标题:Ghosh,Kallol K.; Ghosh,Sharmistha; Thakur,Santosh S.,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1996,Vol. 35,# 2,P. 121-126
专利号:US-6063919-A 优先权日:1998-08-14 标题:Process for the synthesis of exochelins 发明人:GAUDIOSO LARRY A; WEGLARZ MICHAEL A 权利人:KEYSTONE BIOMEDICAL INC 摘要:A process for the synthesis of an Exochelin comprising the steps of generating L-N-[(2-benzyloxy-(benzoyl)] serine or L-N-[2-benzyloxy (benzoyl)] threonine, creating L-N-t-Boc- epsilon -hydroxynorleucine and reacting same to produce L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester, providing a dicarboxylic acid and forming an O-benzyl methyl hydroxamate from the dicarboxylic acid, coupling the O-benzyl methyl hydroxamate with the L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester to give an L-N2-Boc-N6-methyl,N6-(benzyloxy) lysine 2-trimethylsilylethyl ester which incorporates the dicarboxylic acid as modified above, removing the N-tert-butoxycarbonyl protecting group from the L-N2-Boc-N6-methyl, N6-(benzyloxy) lysine 2-trimethylsilylethyl ester to yield a substituted lysine, and coupling the same with the L-N-[2-benzyloxy (benzoyl) serine or -threonine to yield a 2-trimethyl silylethyl ester of dibenzyl Exochelic acid, transforming the 2-trimethyl silylethyl ester of dibenzyl Exochelic acid to dibenzyl Exochelic acid, preparing benzyl epi-cobactin, forming an ester bond between the dibenzyl Exochelic acid and benzyl epi-cobactin to form an intermediate, and, hydrogenolytically removing three benzyl groups from said intermediate, resulting in the synthesized Exochelin. More particularly, a synthesis for Exochelin 786SM (R) is disclosed wherein the dicarboxylic acid is suberic acid and the serine form is utilized.
专利号:US-10604479-B2 优先权日:2013-11-18 标 题:Continuous process for the one-pot synthesis of metal salts and metal complexes 发明人:LEONARDI GIULIANO; GASPERONI GIOVANNI 权利人:VOLARE & CONNECTING LLC; LEONARDI GIULIANO; NOVUS INT INC 摘要:A continuous process is described for the one-pot synthesis of compounds, such as metal salts and metal complexes, as well as optionally for the protection of the compounds thus obtained by coating and/or impregnation with suitable compounds.
专利号:US-5405949-A 优先权日:1993-03-29 标题 :Process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the α-L-iduronic-2-O-sulfate acid 发明人:UNGARELLI FABRIZIO; PIANI SILVANO 权利人:ALFA WASSERMANN SPA 摘要:A process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the α-L-iduronic-2-O-sulfate acid in which the sulfate group is, entirely or in part, substituted with a nucleophilic group, is described. The process is carried out by treating glycosaminoglycans having heparin or heparan structure with a nucleophilic reagent in alkaline solution.
专利号:US-2017267706-A1 优先权日:2014-08-19 标 题:Method for the synthesis of heterocyclic hydrogen phosphine oxide 发明人:BRUYNEEL FREDERIC; NOTTE PATRICK PIERRE 权利人:STRAITMARK HOLDING AG 摘要:A method for the synthesis of a heterocyclic hydrogen phosphine oxide, having the general formula: n n n n n n n n n n wherein:n nR is a aliphatic or aromatic divalent group optionally including one or more heteroatoms and optionally having one or more substituents andn nX and Y are independently selected from —O—, —C(O)O— and —NR′—n nwherein R′ is a monovalent group optionally having one or more heteroatoms including the steps of:n na) forming a reaction mixture by mixing a compound having the general formula HX—R—YH and tetraphosphorus hexaoxide; andn nb) recovering the resulting compound comprising the heterocyclic hydrogen phosphine oxide.
专利号:US-7544831-B2 优先权日:2007-09-21 标题:Green catalytic process for the synthesis of acetyl salicylic acid 发明人:JASRA RAKSH VIR; TYAGI BEENA; MISHRA MANISH KUMAR 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides a green catalytic process for the synthesis of acetyl salicylic acid using solid acid catalysts at atmospheric pressure. The invention involve the solid acid catalyst such as sulfated transition metal oxides namely nano-crystalline sulfated zirconia, sulfated titania; modified zeolites namely zeolite H-beta, H-Y, H-ZSM-5 and K-10 montmorillonite clay in a solvent free environment using salicylic acid and acetic anhydride with yield about 95% and high selectivity (100%). The solid acid catalysts can be recovered, regenerated and reused.
专利号:US-5410039-A 优先权日:1993-03-29 标题 :Process for the synthesis of glycosaminoglycans containing α-L-galacturonic acid substituted with nucleophilic groups in position 3 发明人:UNGARELLI FABRIZIO; PIANI SILVANO 权利人:ALFA WASSERMANN SPA 摘要:A process for the synthesis of glycosaminoglycans in which one of the α-L-iduronic-2-O-sulfate acid saccharide units, which is characteristic of glycosaminoglycans with heparin or heparan structure, has undergone a structural modification, entirely or in part, with transformation into α-L-galacturonic acid substituted in position 3 with nucleophilic groups, is described. The process is carried out by treating glycosaminoglycans having heparin or heparan structure with a nucleophilic reagent in alkaline solution.
[参考文献]: Mitchell Ja, Et Al. Sodium Salicylate Inhibits Cyclo-Oxygenase-2 Activity Independently Of Transcription Factor (Nuclear Factor Kappab) Activation: Role Of Arachidonic Acid. Mol Pharmacol. 1997 Jun;51(6):907-12. [参考文献]: Nixon M, Et Al. Salicylate Downregulates 11β-Hsd1 Expression In Adipose Tissue In Obese Mice And In Humans, Mediating Insulin Sensitization. Diabetes. 2012 Apr;61(4):790-6. [参考文献]: Andrea M Binnebose, Et Al. Polyanhydride Nanoparticle Delivery Platform Dramatically Enhances Killing Of Filarial Worms. Plos Negl Trop Dis. 2015 Oct 23;9(10):E0004173. [参考文献]: Jianling Liu, Et Al. Pathway As A Pharmacological Target For Herbal Medicines: An Investigation From Reduning Injection. Plos One. 2015 Apr 1;10(4):E0123109. [参考文献]: Julia E Vela-Ramirez, Et Al. Safety And Biocompatibility Of Carbohydrate-Functionalized Polyanhydride Nanoparticles. Aaps J. 2015 Jan;17(1):256-67.
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198 摘要:HANSCH,C ET AL. (1995) 参考文献:10.1093/pcp/pcy091 摘要:Zhu J, Wang X, Guo L, Xu Q, Zhao S, Li F, Yan X, Liu S, Wei C. Characterization and Alternative Splicing Profiles of the Lipoxygenase Gene Family in Tea Plant (Camellia sinensis). Plant Cell Physiol. 2018 Sep 01;59(9):1765–81.