CAS: 83664-33-9; 2-(Benzyloxy)-5-Bromopyridine

该化合物是一种有机化合物,其特点是以溴原子和苯氧基组物取代了环,在环的5处放置了溴原子,这有利于其再活性,使其成为各种化学合成物中的有用中间体.苯氧基组是乙醚功能组,它增强了化合物在有机溶剂中的溶解性,并能够参与核细胞替代反应.该化合物一般是固体,可能显示出中度至高的熔点和沸点,取决于其纯度和晶状.其分子结构允许在医药化学中,特别是在药品的开发中,由于生物活动往往与溴化丙烯衍生物相关联.此外,2-苯氧基-5-溴丙烯基酮可以作为合成更复杂的有机分子的建筑块,使其在研究和工业应用中具有价值.应当参考安全数据,以便处理和储存化学物质.

结构式图片

相似化合物

52200-49-4 936343-08-7 2090855-71-1

物理性质

MSDS等安全信息

上下游产品

CAS号13466-38-1 2-羟基-5-溴吡啶 | CAS号100-39-0 溴化苄 | CAS号624-28-2 2,5-二溴吡啶 | CAS号100-51-6 苯甲醇 | CAS号766-11-0 5-溴-2-氟吡啶 | CAS号39856-50-3 5-溴-2-硝基吡啶 | CAS号106154-29-4 2-phenylmethoxy... | CAS号861884-65-3 4-(6-(benzyloxy... | CAS号40864-08-2 2-(苄氧基)吡啶 | CAS号635712-99-1 6-(苄氧基)烟醛 | CAS号106984-91-2 2-羟基-5-吡啶甲醛 | CAS号62749-34-2 5-pyridin-4-yl-...

合成工艺路线路线简述

  • 100-51-6 + 766-11-0 = 83664-33-9
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 30 Min,0 °C1.2 Overnight,70 °C1.3 Reagents: Water
    标题:Optimization Of Triarylpyridinone Inhibitors Of The Main Protease Of Sars-Cov-2 To Low-Nanomolar Antiviral Potency
    作者:Zhang,Chun-Hui; Et Al
    参考文献:Acs Medicinal Chemistry Letters 日期:2021 卷标:12(8) 页码:1325-1332]

    1072-97-5 = 83664-33-9
    反应条件:1.1 Reagents: Sulfuric Acid Solvents: Water; Rt -> 5 °C1.2 Reagents: Sulfuric Acid,Hydrogen Peroxide Solvents: Water; Overnight,Rt1.3 Reagents: Potassium Hydroxide Solvents: Water; Basified,Rt2.1 Reagents: Cesium Carbonate Catalysts: 1,10-Phenanthroline,Cuprous Iodide Solvents: Toluene; 24 H,110 °C
    标题:A Simple Cu-Catalyzed Coupling Approach To Substituted 3-Pyridinol And 5-Pyrimidinol Antioxidants
    作者:Nara,Susheel J.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2008 卷标:73(23) 页码:9326-9333]

    = 83664-33-9
    反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 0 °C; Overnight,Rt2.1 Reagents: Sulfuric Acid Solvents: Water; Rt -> 5 °C2.2 Reagents: Sulfuric Acid,Hydrogen Peroxide Solvents: Water; Overnight,Rt2.3 Reagents: Potassium Hydroxide Solvents: Water; Basified,Rt3.1 Reagents: Cesium Carbonate Catalysts: 1,10-Phenanthroline,Cuprous Iodide Solvents: Toluene; 24 H,110 °C
    标题:A Simple Cu-Catalyzed Coupling Approach To Substituted 3-Pyridinol And 5-Pyrimidinol Antioxidants
    作者:Nara,Susheel J.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2008 卷标:73(23) 页码:9326-9333]

    13466-38-1 = 83664-33-9 + 217448-53-8
    反应条件:1.1 Reagents: Diisopropylethylamine,Polyoxyethylene Sorbitan Monolaurate Solvents: Water; 3 H,Rt1.2 Reagents: Methanol
    标题:Mild And Regioselective N-Alkylation Of 2-Pyridones In Water
    作者:Hao,Xin; Et Al
    参考文献:Organic Letters 日期:2015 卷标:17(14) 页码:3382-3385]

    624-28-2 + 100-51-6 = 83664-33-9
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; Cooled; 30 Min,Rt1.2 Solvents: Dimethylformamide; Rt; 5 H,Rt1.3 Solvents: Acetic Acid; 0 °C; 30 Min,0 °C
    标题:Pyridone Derivatives Carrying Radical Moieties: Hydrogen-Bonded Structures,Magnetic Properties,And Metal Coordination
    作者:Ueda,Mikio; Et Al
    参考文献:Polyhedron 日期:2013 卷标:52 页码:755-760]

    13466-38-1 = 83664-33-9
    反应条件:1.1 Reagents: Zinc Oxide (Zno),Diisopropylethylamine,Zinc Chloride Solvents: 1,4-Dioxane; 110 °C
    标题:Zinc(Ii)-Mediated Selective O-Benzylation Of 2-Oxo-1,2-Dihydropyridines Systems
    作者:Zhou,Qifan; Et Al
    参考文献:Molecules 日期:2018 卷标:23(7) 页码:1784/1-1784/14]

    13472-85-0 + 100-51-6 = 83664-33-9
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 20 Min,0 °C1.2 Solvents: Tetrahydrofuran; 30 Min,0 °C; 0 °C -> Rt; 12 H,Rt1.3 Reagents: Water; Cooled
    标题:Design And Synthesis Of 2-Pyridones As Novel Inhibitors Of The Bacillus Anthracis Enoyl-Acp Reductase
    作者:Tipparaju,Suresh K.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2008 卷标:18(12) 页码:3565-3569]

    39856-50-3 + 100-51-6 = 83664-33-9
    反应条件:1.1 Reagents: Cesium Carbonate Catalysts: 1,10-Phenanthroline,Cuprous Iodide Solvents: Toluene; 24 H,110 °C
    标题:A Simple Cu-Catalyzed Coupling Approach To Substituted 3-Pyridinol And 5-Pyrimidinol Antioxidants
    作者:Nara,Susheel J.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2008 卷标:73(23) 页码:9326-9333]

    13466-38-1 = 83664-33-9 + 217448-53-8
    反应条件:1.1 Reagents: Diisopropylethylamine,Polyoxyethylene Sorbitan Monolaurate Solvents: Water; 6 D,Rt1.2 Reagents: Methanol
    标题:Mild And Regioselective N-Alkylation Of 2-Pyridones In Water
    作者:Hao,Xin; Et Al
    参考文献:Organic Letters 日期:2015 卷标:17(14) 页码:3382-3385
2,5-二溴吡啶置于sodium Hydride体系中,用 Dmf (N,N-Dimethyl-Formamide) 作为反应溶剂,化学反应 3.5H,反应生成 2-苄氧基-5-溴吡啶
参考文献:Pyrimidine Compound And Medicinal Composition Thereof
标题:Pyrimidine Compound And Medicinal Composition Thereof

海关参考信息

专利信息


专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

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主要参考文献

参考标题:Synthesis Of Amido-N-Imidazolium Salts And Their Applications As Ligands In Suzuki-Miyaura Reactions: Coupling Of Hetero- Aromatic Halides And The Synthesis Of Milrinone And Irbesartan
作者:Manian Rajesh Kumar,Kyungho Park,Sunwoo Lee |发布日期:2010.12.17
摘要:Catalytic System Based On Palladium-Amido-N-Heterocyclic Carbenes For Suzuki-Miyaura Coupling Reactions Of Heteroaryl Bromides Is Described. A Variety Of Sterically Bulky, Amido-N-Imidazolium Salts Were Synthesized In High Yields From The Corresponding Anilines. This Catalytic System Effectively Promoted Suzuki-Miyaura Couplings Of Heteroaryl Bromides And Chlorides With A Range Of Boronic Acids To

合成参考文献


摘要:Spitzner, D., Science of Synthesis, (2005) 15, 176.
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