CAS: 1124-33-0; 4-Nitropyridine 1-Oxide

相似化合物

5470-66-6 1074-98-2 14432-16-7

上下游产品

CAS号694-59-7 吡啶-N-氧化物 | CAS号16527-88-1 1-oxidopyridin-... | CAS号1122-61-8 4-硝基吡啶 | CAS号120309-62-8 | CAS号7664-93-9 硫酸 | CAS号7697-37-2 硝酸 | CAS号33399-46-1 4-乙氧基吡啶 | CAS号31872-57-8 4-羟基-3-硝基吡啶-1-氧化物 | CAS号36953-41-0 3-溴-4-羟基吡啶 | CAS号14474-56-7 4-乙氧基吡啶n-氧化物 | CAS号14163-00-9 N-氧代-4-硝基-2,2’联吡啶 | CAS号14151-21-4 4-氨基-2,2'-联吡啶 | CAS号504-24-5 4-氨基吡啶 | CAS号3535-75-9 4-氨基吡啶 1-氧化物 | CAS号19349-78-1 3-氨基-4-硝基吡啶 n-氧化物

吡啶-N-氧化物置于硫酸,硝酸体系中,化学反应 0.3H,以85%的收率获得4-硝基吡啶-N-氧化物
参考文献:A Two-Step Continuous Flow Synthesis Of 4-Nitropyridine
标题:A Two-Step Continuous Flow Synthesis Of 4-Nitropyridine
摘要:以吡啶 N-氧化物为原料,通过两步法成功制备了医药产品的关键中间体 4-硝基吡啶.吡啶 N-氧化物经 Hno3 和 H2So4 硝化后反应生成4-硝基吡啶 N-氧化物,然后与 Pcl3 反应生成最终产品.采用连续流方法可最大限度地减少高能量和潜在爆炸性硝化产物的积累,从而实现 4-硝基吡啶的安全放大,且不产生 2-硝基吡啶副产品.通过在硝化步骤中采用连续萃取和优化条件,在连续流系统中,每天可从 N-氧化吡啶中提取 0.716 千克 4-硝基吡啶产品,产率达 83%,并具有高选择性.
Doi:10.3184/174751915X14269588490798

专利信息

专利号:US-8877935-B2
优先权日:2010-06-08
标 题:One-pot process for the synthesis of dalfampridine
发明人：GARAVAGLIA FABIO; BAROZZA ALESSANDRO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:GARAVAGLIA FABIO; BAROZZA ALESSANDRO; ROLETTO JACOPO; PAISSONI PAOLO; PROCOS SPA
摘要:A process for the preparation of Dalfampridine (1), 4-aminopyridine, starting from 4-pyridinecarbonitrile using a one-pot procedure. n n n n n n n n n n Said process is carried out with no need for isolating intermediates and is particularly advantageous as far as environment, yields, productivity and purity of the resulting product are concerned, both in the reaction mixture and in the isolated crystal.

专利号:US-7022846-B2
优先权日:2002-06-10
标 题 :Metabolites of prinomastat and their synthesis
发明人：OUELLETTE MICHAEL A; POTTS BARBARA C M; SRIRANGAM JAYARAM K; TIBBETTS ANTHONY R; ZHANG KANYIN E
权利人:AGOURON PHARMA
摘要:Metabolites of a matrix metalloproteinase inhibitor prinomastat and their synthesis. These metabolites are: (3S)-N-hydroxy-4-(4-((1-oxy-pyrid-4-yl)oxy)benzenesulfonyl)-2,2-dimethyl-tetrahydro-2H-1,4-thiazine-3-carboxamide (M6); (3S)-2,2-dimethyl-1,1-dioxo-4-[4-(1-oxy-pyridin-4-yloxy)-benzenesulfonyl]-thiomorpholine-3-carboxylic acid amide (M7); (3S)-2,2-dimethyl-4-[4-(1-oxypyridin-4-yloxy)-benzenesulfonyl]-thiomorpholine-3-carboxylic acid amide (M8); (3S)-2,2-dimethyl-1,1-dioxo-4-[4-(pyridin-4-yloxy)-benzenesulfonyl]-thiomorpholine-3-carboxylic acid amide (M2); and (3S)-2,2-dimethyl-4-[4-(pyridin-4yloxy)-benzenesulfonyl)-thiomorphpline-3-carboxylic acid amide (M3).

专利号:US-2011319628-A1
优先权日:2010-06-08
标题 :One-pot process for the synthesis of dalfampridine

专利号:EP-2394994-B1
优先权日:2010-06-08
标题:One-pot process for the synthesis of dalfampridine

专利号:IT-MI20101015-A1
优先权日:2010-06-08
标题:ONE-POT PROCESS FOR THE SYNTHESIS OF DALFAMPRIDINE

专利号:EP-2394994-A1
优先权日:2010-06-08
标 题 :One-pot process for the synthesis of dalfampridine