CAS: 1861-40-1; Benfluralin

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CAS号393-75-9 4-氯-3,5-二硝基三氟甲苯 | CAS号13360-63-9 N-乙基正丁胺

4-氯-3,5-二硝基三氟甲苯,N-乙基正丁胺置于盐酸体系中,用 乙醚 用作溶剂,化学反应生成氟草胺
参考文献:Regioselectivity And Stereoelectronic Effects In The Reactions Of The Dinitroaniline Herbicides Trifluralin And Benefin With Nucleophiles
标题:Regioselectivity And Stereoelectronic Effects In The Reactions Of The Dinitroaniline Herbicides Trifluralin And Benefin With Nucleophiles
摘要:二种硝基苯胺类除草剂成员,N,N-二正丙基-2,6-二硝基-4-(三氟甲基)苯胺(三氟乙草灵;1)和n-乙基-N-正丁基-2,6-二硝基-4-(三氟甲基)苯胺(苯胺;2),以及它们的类似物n-苯基-2,6-二硝基-4-(三氟甲基)苯胺(3),与亲核试剂od-和so32-的反应已经通过400兆赫1H核磁共振波谱学进行了研究. 1和2与od-的反应导致meisenheimer阴离子σ-络合物的形成,根据k3T1(动力学偏好形成具有热力学偏好形成c-1加合物的c-3加合物)反应序列,而3与od-的反应以及1与so32-的反应遵循k3T3(动力学和热力学偏好形成c-3加合物)序列.没有观测到1和2与od-的c-1加合物,但观测到了在c-1处进行snar位移的产物作为最终热力学产物.几何优化计算支持我们的假设,即n->σ*稳定化c-1加合物导致snar位移.在3与od-的反应中,初始n去质子化形成负离子3A,然后形成σ-络合物.在该系统中观测到的最终热力学产物是通过3A负离子上三氟甲基团的水解形成的3,5-二硝基-4-(N-苯基氨基)苯甲酸.已发现1和2与od-体系的芳基h-D交换,但未发现so32-体系的芳基h-D交换,也未发现3与od-的反应.由于二甲基苦味胺在相同条件下显示出明显较慢的h-D交换,据认为这种差异的起源是氨基n孤对电子能够与环的π-系统相互作用.对于1和2,氨基烷基链的较大尺寸阻止了氨基n孤对与环的π-系统对齐,从而阻碍了电子密度对电子亏缺的环碳的捐赠.关键词:三氟乙草灵,苯胺,除草剂,Meisenheimer络合物,立体电子效应.
Doi:10.1139/v98-089

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:WO-2024256370-A1
优先权日:2023-06-13
标 题 :Synthesis of glufosinate using an amidase-based process
发明人：ZIMMERMANN GUNTHER; POTT MORITZ STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.

专利号:US-2025120400-A1
优先权日:2021-12-10
标题:Synthesis of glufosinate using a hydantoinase-based process
发明人：DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.

专利号:US-9102708-B2
优先权日:2006-02-17
标 题:Methods for the synthesis of dicarba bridges in organic compounds
发明人：ROBINSON ANDREA JANE; JACKSON WILLIAM ROY; PATEL JIM; ELARIDI JOMANA
权利人:ROBINSON ANDREA JANE; JACKSON WILLIAM ROY; PATEL JIM; ELARIDI JOMANA; SYNGENE LTD
摘要:The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.

专利号:US-8759480-B2
优先权日:2006-02-17
标题:Contoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides
发明人：ROBINSON ANDREA; ELARIDI JOMANA
权利人:ROBINSON ANDREA; ELARIDI JOMANA; SYNGENE LTD
摘要:According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides.