专利号:US-2007004010-A1 优先权日:2002-09-12 标题 :Engineered Enzymes and Their Use for Synthesis of Thioglycosides 发明人:WITHERS STEPHEN G; JAHN MICHAEL 权利人:UNIV BRITISH COLUMBIA 摘要:Mutant glycosidases in which the amino acid in the active site that serves as the acid, base or acid/base-catalyst is converted from a carboxylic acid to some other amino acid (for example to a simple alkyl, as in alanine or glycine) can catalyze the reaction of a thiosugar acceptor and an activated donor to form a thioglycoside. The “thioglycoligasesâ€? represent a novel class of mutant enzymes, and represent a first aspect of the invention. Thioglycoligases can be used in accordance with the method of the invention to couple a thiosugar acceptor and an activated donor to form a thioglycoside. By selection of the donor and acceptor species, as well as the specific enzyme employed, thioglycosides of different structure and stereochemistry can be obtained.
专利号:US-5104856-A 优先权日:1990-11-09 标题:Heparan sulfate biosynthesis primers 发明人:ESKO JEFFREY D; LUGEMWA FULGENTIUS N 权利人:UAB RESEARCH FOUNDATION 摘要:Conjugates of β-D-xylose with estrogens or modified forms of estrogens are effective in stimulating the synthesis of heparan sulfate, and inhibiting the production of proteoglycan in animal subjects. Accordingly, these conjugates are useful in treating conditions where antithrombotic or antiproliferative activity is desirable.
专利号:US-10526593-B2 优先权日:2015-07-09 标 题 :Method for obtaining a composition for biomass hydrolysis 发明人:YAZDANI SYED SHAMS; OGUNMOLU FUNSO EMMANUEL 权利人:INT CENTRE FOR GENETIC ENGINEERING & BIOTECHNOLOGY; DEPARTMENT OF BIOTECH MINISTRY OF SCIENCE & TECH 摘要:The present invention discloses a composition for biomass hydrolysis. The components of the composition may be obtained by biological or synthetic means. Synthetically, the components of the composition of the present invention may be obtained by amino acid synthesis or may be procured commercially.
专利号:US-2006035342-A1 优先权日:2002-09-12 标 题:Engineered enzymes and their use for synthesis of thioglycosides
专利号:WO-2004024908-A1 优先权日:2002-09-12 标 题 :Engineered enzymes and their use for synthesis of thioglycosides
专利号:WO-2019234295-A1 优先权日:2018-06-05 标 题 :Beta glucosidase with high glucose tolerance, high thermal stability and broad ph activity spectrum 发明人:MARJAMAA KAISA; KOIVULA ANU; ARO NINA; PAKULA TIINA 权利人:TEKNOLOGIAN TUTKIMUSKESKUS VTT OY 摘要:The present invention relates to polypeptide having beta-glucosidase activity. Said activity is retained also in high glucose concentration. The invention also relates to an isolated polynucleotide, a nucleic acid construct and a recombinant host usable in production of said polypeptide, and a method for producing said polypeptide. Further the invention relates to compositions comprising said polypeptide and method of using the polypeptide in hydrolysis or synthesis.
参考标题:Enzymatic Synthesis Of 2-(β-Galactosyl)-Ethyl Methacrylate By β-Galactosidase From Pyrococcus Woesei And Application For Glycopolymer Synthesis And Lectin Studies 作者:Marius Hoffmann,Elisabeth Gau,Susanne Braun,Andrij Pich,Lothar Elling |发布日期:2020.2.10 摘要:For The Synthesis Of Glycosides By Transglycosylation Reactions. Especially Glycosidases From Hyperthermophilic Bacteria Are Useful For Reactions Under Extreme Reaction Conditions, E.G., In The Presence Of Organic Solvents. We Herein Report The Facile Enzymatic Synthesis And Purification Of 2-(β-Galactosyl)-Ethyl Methacrylate (Gal-Ema) With The Recombinant Hyperthermostable Glycosidase From Pyrococcus
合成参考文献
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