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Hexaethylene Glycol Dibenzyl Ether置于palladium On Activated Charcoal 氢气体系中,用 盐酸,乙醇 用作溶剂,以91%的收率获得六甘醇
参考文献:苯并氮杂鎓和苯胺阳离子套索状醚配合物的合成和性质:"鸵鸟分子"配合物和分子内侧臂-大环相互作用的证据
标题:苯并氮杂鎓和苯胺阳离子套索状醚配合物的合成和性质:"鸵鸟分子"配合物和分子内侧臂-大环相互作用的证据
摘要:报道了几种新型套索状醚(具有带有侧链带有侧基供体基团的大环冠聚醚)的制备.这些化合物是衍生自已知的2-羟甲基-15-冠-5或-21-冠-7的醚.侧臂包括2-氨基苯基,2,4-二氨基苯基,2-硝基苯基,2-(3'-硝基联苯)和2-(3'-氨基联苯).在一些情况下,氨基被转化为铵盐,该铵盐通过分子内氢键显示出基本的稳定性.同样,-Nh 2 +.,Bf 3-该配合物显示出分子内氢键的证据.氨基联苯残基的重氮化反应产生了一个烯二唑鎓阳离子,该阳离子经历了分子内冠状络合,这是通过红外光谱研究判断形成的,我们称之为"鸵鸟分子"复合物.将n,N-二甲基苯胺添加到分子内的芳构氮鎓阳离子络合物中可制得偶氮化合物,但euro移试剂研究清楚地表明,重氮鎓阳离子在大环之外发生了反应.
Doi:10.1016/0040-4020(84)85070-X

专利信息

专利号:US-7956011-B2
优先权日:2005-05-04
标题:Materials and methods for the photodirected synthesis of oligonucleotide arrays
发明人：SERAFINOWSKI PAWEL JERZY; GARLAND PETER BRYAN
权利人:CANCER RES INST ROYAL
摘要:Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator that on photolysis generates acid that is capable of directly removing the protecting group of the linker molecules or oligonucleotides and (ii) a polymer substantially lacking electronegative heteroatoms that are capable of hydrogen bonding with photogenerated acid. Methods of synthesizing an oligomer arrays are also described that use a film that restricts diffusion of reactants and products on the substrate during synthesis of the array and which includes a precursor of a deprotecting reagent. The method involves removing one or more of the non-required products of the deprotection reaction from the reactive array elements at which they are produced during the reaction, in order to displace the deprotection reaction towards completion.

专利号:US-2023313255-A1
优先权日:2020-07-15
标题:Massively Parallel Enzymatic Synthesis of Polynucleotides
发明人：HORGAN ADRIAN; LACHAIZE HENRI; VERARDO DOMIANO; GODRON XAVIER
权利人:DNA SCRIPT
摘要:The invention is directed to methods and compositions for inkjet assisted synthesis of a plurality of polynucleotides at reaction sites on a substrate using template-free polymerases, such as, terminal deoxynucleotidyl transferases (TdTs). Compositions of the invention include formulations of synthesis reagents for inkjet delivery including, but not limited to, TdT coupling reaction buffers and 3′-O-protected dNTP monomers.

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人：MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:WO-2025044766-A1
优先权日:2023-08-31
标题:Use of silicon dioxide microspheres in synthesis of ultra-long oligonucleotide and method for synthesizing ultra-long oligonucleotide
发明人：SHI YONGYONG; ZHANG MANCANG; WANG LIBING; GAO PANPAN; FANG JUN
权利人:UNIV SHANGHAI JIAOTONG; SHANGHAI DYNEGENE TECH CO LTD
摘要:The present invention relates to the technical field of oligonucleotide synthesis. Disclosed are the use of silicon dioxide microspheres in the synthesis of an ultra-long oligonucleotide and a method for synthesizing an ultra-long oligonucleotide, wherein the silicon dioxide microspheres have a specific surface area of less than 1 m2/g, and preferably, the silicon dioxide microspheres have modification groups on the surface. The method for synthesizing an ultra-long oligonucleotide comprises: performing a coupling reaction on a nucleoside phosphoramidite synthesis unit using the silicon dioxide microspheres having modification groups on the surface as carriers under coupling reaction conditions. The prepared carriers can be used to prepare an ultra-long oligonucleotide.

专利号:US-6770436-B1
优先权日:1996-11-14
标题:Chemical amplification for the synthesis of patterned arrays
发明人：BEECHER JODY E; GOLDBERG MARTIN J; MCGALL GLENN H
权利人:AFFYMETRIX INC
摘要:Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions. The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.

专利号:US-8318427-B2
优先权日:2005-12-29
标 题 :Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays
发明人：KUIMELIS ROBERT G; MCGALL GLENN H; GOLDBERG MARTIN J; XU GUANGYU
权利人:KUIMELIS ROBERT G; MCGALL GLENN H; GOLDBERG MARTIN J; XU GUANGYU; AFFYMETRIX INC
摘要:Protective groups which may be cleaved with an activatable deprotecting reagents are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.