CAS: 505-19-1; Hexahydropyridazine

上下游产品

CAS号5311-96-6 1,1-Hydrazinedi... | CAS号110-56-5 1,4-二氯丁烷 | CAS号140200-91-5 1,2,3,6-tetrahy... | CAS号75156-22-8 dimethyl 3,4,5,... | CAS号52944-50-0 diethyl diazina... | CAS号340256-13-5 四氢哒嗪-1,2-二羧酸二叔丁酯 | CAS号68387-96-2 2-methyl-1-[2-(... | CAS号333-93-7 1,4-丁二胺双盐酸盐 | CAS号56-23-5 四氯化碳 | CAS号7732-18-5 水 | CAS号154972-37-9 四氢-吡嗪-1-羧酸叔丁酯 | CAS号3661-15-2 1,6-diazabicycl... | CAS号5721-43-7 hexahydro-pyraz... | CAS号68387-96-2 2-methyl-1-[2-(... | CAS号64030-37-1 3,4,5,6-tetrahy... | CAS号694-06-4 2,3,4,5-Tetrahy... | CAS号89552-73-8 Phosphinothioic... | CAS号5740-50-1 ethyl diazinane... | CAS号5767-20-4 1,2,3,4,6,8,9,1...

1,2-Diisobutyrylpiperidazine置于盐酸体系中,化学反应生成 六氢哒嗪
参考文献:Stetter; Spangenberger,Chemische Berichte,1958,Vol. 91,P. 1982,1987
标题:Stetter; Spangenberger,Chemische Berichte,1958,Vol. 91,P. 1982,1987

专利信息

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-7179919-B2
优先权日:2004-03-18
标 题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：SONG JINHUA J; TAN ZHULIN; YEE NATHAN K; SENANAYAKE CHRIS HUGH; XU JINGHUA; GALLOU FABRICE
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are as described herein.

专利号:US-8471010-B2
优先权日:2008-05-13
标题:Synthesis of dihydrothieno[3,2-d]pyrimidine diols
发明人：FRUTOS ROGELIO P; TAMPONE THOMAS G; MULDER JASON ALAN; KRISHNAMURTHY DHILEEPKUMAR; SENANAYAKE CHRIS H
权利人:FRUTOS ROGELIO P; TAMPONE THOMAS G; MULDER JASON ALAN; KRISHNAMURTHY DHILEEPKUMAR; SENANAYAKE CHRIS H; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.

专利号:US-7507843-B2
优先权日:2003-10-16
标题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：SONG JINHUA J; TAN ZHULIN; XU JINGHUA; YEE NATHAN K; SENANAYAKE CHRIS H
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of compounds of Formula X wherein: R1 is an aryl or heteroaryl group, each optionally independently substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, C1-C5 alkoxy, C2-C5 alkenyloxy, C2-C5 alkynyloxy, aryloxy, C1-C5 alkanoyloxy, C1-C5 alkanoyl, aroyl, trifluoromethyl, trifluoromethoxy, or C1-C5 alkylthio, wherein each substituent group of R1 is optionally independently substituted with one to three substituent groups selected from methyl, methoxy, fluoro, chloro, hydroxy, oxo, cyano, or amino; and R2 and R3 are each independently hydrogen or C1-C5 alkyl, or R2 and R3 together with the carbon atom they are commonly attached to form a C3-C8 spiro cycloalkyl ring.

专利号:EP-2280974-B1
优先权日:2008-04-30
标题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：REEVES JONATHAN TIMOTHY; SONG JINHUA J; TAN ZHULIN
权利人:BOEHRINGER INGELHEIM INT; BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.

专利号:WO-2024018354-A1
优先权日:2022-07-18
标题 :A process for the synthesis of 4-alkoxy-3-hydroxypicolinic acids and intermediates thereof
发明人：MAL SANJIB; SARKAR PARANTAP; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER GUENTHER MARIA
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a process for the synthesis of 4- alkoxy-3-hydroxypicolinic acids of formula (I) from 2-picolinic acid. The present invention further discloses a process for preparation of compounds of formula (iii) from compounds of formula (ii). The present invention also discloses novel intermediate compounds of formula (iii).