异丙基肾上腺酮盐酸盐; 3',4'-二羟基-Alpha-(异丙基氨基)苯乙酮盐酸盐置于palladium 10% On Activated Carbon,氢气体系中,用 甲醇,水 作为反应溶剂,20.0~30.0 °C,500.01 Kpa 条件下,以66.4 G的收率获得产物盐酸异丙肾上腺素 参考文献: Process For Preparation Of Isoproterenol Hydrochloride[fr] Procédé De Préparation De Chlorhydrate D'Isoprotérénol 标题: Process For Preparation Of Isoproterenol Hydrochloride[fr] Procédé De Préparation De Chlorhydrate D'Isoprotérénol 摘要:本发明提供了一种制备异丙肾上腺素盐酸盐(1A)的方法,包括在离子交换树脂的存在下,对3',4'-二羟基-2-(异丙基氨基)-乙酰苯酮盐酸盐(5A)进行催化氢化,以提供异丙肾上腺素盐酸盐(1A).
专利号:US-6030613-A 优先权日:1995-01-17 标题:Receptor specific transepithelial transport of therapeutics 发明人:BLUMBERG RICHARD S; SIMISTER NEIL E; LENCER WAYNE I 权利人:BRIGHAM & WOMENS HOSPITAL; UNIV BRANDEIS 摘要:The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
专利号:US-4035405-A 优先权日:1976-07-09 标题 :Novel synthesis for preparing the hydrochloride salt of selected catecholamine derivatives 发明人:BODOR NICOLAE S; YUAN SUN-SHINE 权利人:INTERX RESEARCH CORP 摘要:Compounds of the formula: ##STR1## wherein R represents a straight or branched C 1 -C 5 alkyl group; and R 1 in each occurrence represents an acyl member which is alkanoyl having 1-22 carbon atoms, alkenoyl having one or two double bonds and having 4-22 carbon atoms, ##STR2## having a total of 4-10 carbon atoms of which 3-7 are ring carbon atoms in cycloalkyl and wherein n is zero, one, or two, phenoxyacetyl, naphthalenecarbonyl, pyridinecarbonyl, ##STR3## wherein n is zero, one or two and phenyl is unsubstituted or is substituted by 1-3 alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms, halo, trifluoromethyl, dialkylamino having 2-8 carbon atoms, or alkanoylamino having 1-6 carbon atoms groups; are prepared in substantial purity and yield, using as the chloride ion donor, cesium chloride (CsCl). n The compounds prepared by the process claimed herein exhibit sympathomimetic activity and are thus useful in eliciting sympathomimetic responses in warm-blooded animals, e.g., reduction in intraocular pressure, miosis, mydriasis, bronchodilation, etc.
专利号:US-7547436-B2 优先权日:1995-01-17 标 题:Receptor specific transepithelial transport of therapeutics 发明人:BLUMBERG RICHARD S; LENCER WAYNE I; SIMISTER NEIL E 权利人:BRIGHAM & WOMENS HOSPITAL; UNIV BRANDEIS 摘要:The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
专利号:US-5118601-A 优先权日:1986-03-27 标题:Method of screening purine nucleoside compounds or analogs for the ability to enhance the cellular synthesis and release of adenosine 发明人:GRUBER HARRY E 权利人:UNIV CALIFORNIA 摘要:Methods for increasing extracellular concentrations of adenosine for the prophylactic or affirmative treatment of diseases of the immune, nervous, cardiac, and vascular systems involving administering to a patient purine nucleoside and purine nucleoside-related analogs which increase extracellular adenosine concentration, and methods for stabilizing mast cells by the suppression of mast cell activation using such compounds.
专利号:US-2013030282-A1 优先权日:2011-07-18 标题:Synthesis and characterization of near ir fluorescent magnetic and non-magnetic albumin nanoparticles for biomedical applications 发明人:MARGEL SHLOMO; COHEN SARIT; SALKMON ENAV COREM; PELLACH MICHAL 权利人:UNIV BAR ILAN; MARGEL SHLOMO; COHEN SARIT; SALKMON ENAV COREM; PELLACH MICHAL 摘要:The present invention discloses Near Infrared (NIR) fluorescent albumin nanoparticles having a structure selected from a core structure or a core-shell structure. Also disclosed are a process of preparing these NIR fluorescent albumin nanoparticles, and a method of in vivo detection of pathologies, in particular cancer pathology, by using administering these NIR fluorescent albumin nanoparticles to a patient.
专利号:CA-3012054-A1 优先权日:2016-03-16 标题:Microbial synthesis of isoprenoid precursors, isoprenoids and derivatives including prenylated aromatics compounds
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合成参考文献
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