CAS: 52605-98-8; 5-Bromo-2,3-Dimethoxypyridine

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1211589-04-6 106331-71-9 1241752-31-7

上下游产品

CAS号52605-97-7 2,3-二甲氧基吡啶 | CAS号1142191-57-8 2,5-二溴-3-甲氧基吡啶 | CAS号124-41-4 甲醇钠 | CAS号286947-03-3 5-溴-2-氯-3-甲氧基吡啶 | CAS号141-52-6 乙醇钠 | CAS号52605-96-6 2-氯-3-甲氧基吡啶 | CAS号6636-78-8 2-氯-3-羟基吡啶 | CAS号67-56-1 甲醇 | CAS号20265-37-6 2-硝基-3-甲氧基吡啶 | CAS号10201-71-5 2-氨基-3-甲氧基吡啶 | CAS号52605-99-9 5,6-二甲氧基烟醛 | CAS号1083168-92-6 2,3-二甲氧基-5-(4,4... | CAS号1171919-88-2 2,3-二甲氧基-5-((三甲...

3-溴-5-甲氧基吡啶-1-氧化物置于三氯氧磷体系中,用 氯仿 作为反应溶剂,化学反应 14.0H,反应生成 5-溴-2,3-二甲氧基吡啶
参考文献:Ep2426135
标题:Ep2426135

专利信息

专利号:US-11702430-B2
优先权日:2018-04-03
标 题:Aza-benzothiophene compounds as STING agonists
发明人：ALTMAN MICHAEL D; CASH BRANDON D; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW M; JEWELL JAMES P; LARSEN MATTHEW A; LU MIN; OTTE RYAN D; TAOKA BRANDON M; TROTTER BENJAMIN WESLEY; TRUONG QUANG T
权利人:MERCK SHARP & DOHME LLC; ALTMAN MICHAEL D; CASH BRANDON D; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW M; JEWELL JAMES P; LARSEN MATTHEW A; LU MIN; OTTE RYAN D; TAOKA BRANDON M; TROTTER BENJAMIN WESLEY; TRUONG QUANG T
摘要:Compounds of general formula (I), and their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , R 5 , R 6 , R 8 , R 9 , A, X 1 , X 2 , and X 3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

专利号:US-2024116909-A1
优先权日:2021-01-12
标题 :Novel compounds useful as sting agonists and uses thereof
发明人：YE YANG; LI XIUWEI; YANG GUIQUN; YAN FASHUN; WANG YANPING; LONG WEI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Compounds of general Formula I, II, III, IV, V and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.

专利号:US-2025108123-A1
优先权日:2021-12-17
标 题:Compound-linker constructs comprising novel compounds useful as sting agonists and uses thereof
发明人：YE YANG; LI XIUWEI; YANG GUIQUN; WANG HONGLING; FANG XIONG; CUI YANKAI; YAN FASHUN; SONG BINHUA
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Provided herein are compound-linker constructs and antibody-drug-conjugates of compounds of formula (Y-1), (Y-2), (Y-3), (A), (B), (C), I, II, III, IV or V that are useful as modulators of STING (Stimulator of Interferon Genes). Also provided are synthesis, compositions and uses of such compound-linker constructs and antibody-drug-conjugates.