L-酪氨酸,苯甲醇置于对甲苯磺酸,对甲苯磺酰氯体系中,用91%的收率获得产物l-酪氨酸苄酯对甲苯磺酸盐 参考文献:A Simple And Convenient Method For Esterification Of Tryptophan And Other Amino Acids 标题:A Simple And Convenient Method For Esterification Of Tryptophan And Other Amino Acids 摘要: DOI:10.1021/jo00149A024
专利号:US-10442757-B2 优先权日:2017-06-07 标 题 :Synthesis of tyrosine derived diphenol monomers 发明人:PULAPURA SATISH; BUEVICH FATIMA; CHEN XIANGJI; LYU SUPING 权利人:TYRX INC; MEDTRONIC INC 摘要:A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCI HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.
专利号:WO-2018226340-A1 优先权日:2017-06-07 标题:Synthesis of tyrosine derived diphenol monomers
专利号:US-2018354892-A1 优先权日:2017-06-07 标题:Synthesis of tyrosine derived diphenol monomers
专利号:EP-3634944-A1 优先权日:2017-06-07 标 题 :Synthesis of tyrosine derived diphenol monomers
专利号:CN-110637007-B 优先权日:2017-06-07 标 题:Synthesis of tyrosine-derived diphenolic monomers
专利号:CN-110637007-B9 优先权日:2017-06-07 标 题 :Synthesis of tyrosine-derived diphenolic monomers
[参考文献]: J Brtko, Et Al. Effect Of Protease Inhibitors And Substrates On 3,5,3'-Triiodothyronine Binding To Rat Liver Nuclear Receptors. Endocr Regul. 1992 Sep;26(3):127-31. [参考文献]: Sangkyu Park, Et Al. Endosperm-Specific Expression Of Tyramine N-Hydroxycinnamoyltransferase And Tyrosine Decarboxylase From A Single Self-Processing Polypeptide Produces High Levels Of Tyramine Derivatives In Rice Seeds. Biotechnol Lett. 2009 Jun;31(6):911-5.