CAS: 57395-89-8; 4-Fluoropiperidine Hydrochloride

相似化合物

78197-27-0 144230-52-4 21987-29-1

专利信息

专利号:US-2024383853-A1
优先权日:2021-09-28
标题:Oximes and their use in treatment of gba-related diseases
发明人：NEVE SØREN; BROWN WILLIAM DALBY; THIRSTRUP KENNETH
权利人:ZEVRA DENMARK AS
摘要:The present invention relates to oximes, their synthesis, and their use for increasing GBA activity and/or levels as well as treatment of GBA-related diseases, such as Parkinson's disease.

专利号:WO-2023081730-A1
优先权日:2021-11-03
标 题:4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer
发明人：ELZEIN ELFATIH; LIU JIWEN
权利人:TEON THERAPEUTICS INC
摘要:The present invention relates to 82 specific 4-hydroxy-2-oxo-1,2- dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid CB2 receptor modulators for the treatment of cancer, e.g. to 6-(4- fluorophenyl)-4-hydroxy-1-(2-(4-methylpiperazin-1-yl)ethyl)-2-oxo-N- (spiro[2.3]hexan-5-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxamide (example 1, compound 1) The present description discloses the synthesis and characterisation of the 82 claimed compounds as well as biological assays thereof.

专利号:US-9957277-B2
优先权日:2015-11-25
标题 :eIF4A-inhibiting compounds and methods related thereto
发明人：ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; TRAN CHINH VIET; PACKARD Garrick Kenneth; XIANG ALAN X; NILEWSKI CHRISTIAN; MICHELS THEO
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds X, Y, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b and R 5 are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.