CAS: 98106-17-3; 6-Fluoro-1-(4-Fluorophenyl)-7-(4-Methylpiperazin-1-yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid

上下游产品

CAS号704-10-9 2,4-二氯-5-氟苯乙酮 | CAS号86483-51-4 2,4-二氯-5-氟-Β-氧代苯丙酸乙酯 | CAS号86483-52-5 2-(2,4-二氯-5-氟苯甲... | CAS号109-01-3 N-甲基哌嗪 | CAS号98105-79-4 7-氯-6-氟-1-对氟苯基-... | CAS号98349-24-7 2,4,5-三氟苯甲酰乙酸乙酯 | CAS号108138-16-5 1-(p-fluorophen...

2,4,5-三氟苯甲酰乙酸乙酯置于盐酸,水,乙酸酐,Sodium Hydride,溶剂黄146,三乙胺体系中,用 四氢呋喃,二氯甲烷,乙腈,Mineral Oil 作为反应溶剂,化学反应生成 双氟沙星
参考文献:Synthesis Of [1-15N,2-13C]-Labeled Difloxacin
标题:Synthesis Of [1-15N,2-13C]-Labeled Difloxacin
摘要:The Synthesis Of [1-N-15,2-C-13]-Difloxacin,An Arylfluoroquinolone Antibacterial Agent,Is Reported. As A Crucial Initial Step,The Starting Materials Ethyl 2,4,5-Trifluorobenzoylacetate,[formyl-C-13]-Triethyl Orthoformate,And [n-15]-4-Fluoroaniline Were Reacted To Ethyl [n-15,3-C-13]-3-(4-Fluoroanilino)-2-(2,4,5-Trifluorobenzoyl) Acrylate. After Cyclization And Ester Cleavage,The Resulting Intermediate Was Reacted With 1-Methylpiperazine To [1-N-15,2-C-13]-1-(4-Fluorophenyl)-6-Fluoro-7-(4-Methyl-1-Piperazinyl)-1,4-Dihydro-4-Oxoquinoline-3-Carboxylate,I.E.,[1-N-15,2-C-13]-Difloxacin. The Overall Yield Was 62% Based On The Non-Labeled And 43% Based On The Labeled Starting Materials (Both Used In 1.4 Molar Excess). The Product Was Identified By H-1-,C-13-,And N-15-NMR Spectroscopy And By Cochromatography (Tlc,HPLC) With An Authentic Reference; Its Purity (HPLC) Was Above 98%. Prior To Synthesis Of [1-N-15,2-C-13]-Difloxacin,Non-Labeled Difloxacin Was Synthesized In Order To Optimize Procedures And To Identify And Characterize All Intermediates.
DOI:10.1007/s00706-009-0158-Y

专利信息

专利号:US-11332444-B2
优先权日:2018-04-25
标题:Method for the hydrolysis of quinolonecarboxylic esters
发明人：FEY PETER; BERWE MATHIAS; WIRTHS Joerg; WISCHNAT RALF; LONGERICH MARKUS; DIETZEL ANTJE
权利人:BAYER ANIMAL HEALTH GMBH
摘要:Quinolonecarboxylic esters of the general formula (II) are hydrolyzed to quinolonecarboxylic acids of the general formula (I):The method comprises the step A):A) reacting compounds of the formula (II) with a mixture comprising acetic acid, sulfuric acid and waterIn step A), ≥30 to ≤40 mol of acetic acid, ≥0.3 to ≤1 mol of sulfuric acid and ≥0.9 to ≤2.5 mol of water are used per mole of compounds of the formula (II). The method is particularly suitable for the synthesis of the intermediate (I) in the synthesis of pradofloxacin.

专利号:US-8093381-B2
优先权日:2007-05-24
标题:Method of synthesis of fluoroquinolones
发明人：BERTHON-CEDILLE LAURENCE; LEGUERN MARIE-EMMANUELLE; RENAUD GILLES; TOMBRET FRANCIS
权利人:BERTHON-CEDILLE LAURENCE; LEGUERN MARIE-EMMANUELLE; RENAUD GILLES; TOMBRET FRANCIS; BIOCODEX
摘要:The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): n nin which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and X are as defined in Claim 1.

专利号:US-2009054643-A1
优先权日:2007-05-24
标 题:Novel method of synthesis of fluoroquinolones

专利号:EP-2138490-B1
优先权日:2007-05-24
标题 :New method for synthesis of fluoroquinolones

专利号:CN-118894976-A
优先权日:2024-09-30
标题 :Synthesis method and application of zwitterionic covalent organic framework nano-sheet

专利号:CN-118894976-B
优先权日:2024-09-30
标题:Synthesis method and application of zwitterionic covalent organic framework nanosheets