CAS: 116855-08-4; 1H-Pyrazolo[3,4-B]Pyridine-3-Carboxylic Acid

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1-(2-氯吡啶-3-基)乙醇置于chromium(Vi) Oxide,Potassium Permanganate,一水合肼,Sodium Hydroxide体系中,用 水,丙酮,正丁醇 用作溶剂,化学反应 7.25H,反应生成1H-吡唑基[3,4-B]吡啶-3-羧酸
参考文献:3-(3H-Imidazo[4,5-B]Pyridin-2-yl)-1H-Pyrazolo[3,4-B]Pyridine And Therapeutic Uses Thereof
标题:3-(3H-Imidazo[4,5-B]Pyridin-2-yl)-1H-Pyrazolo[3,4-B]Pyridine And Therapeutic Uses Thereof
摘要:Azaindazole化合物用于治疗各种疾病和病理已被披露.更具体地,本发明涉及使用azaindazole化合物或其类似物,治疗由wnt途径信号激活所特征的疾病(例如癌症,异常细胞增殖,血管生成,纤维化疾病,骨骼或软骨疾病和骨关节炎),调节由wnt途径信号介导的细胞事件,以及由于wnt途径和/或一个或多个wnt信号组分的突变或失调而导致的遗传疾病和神经病理条件/障碍/疾病.还提供了治疗与wnt相关疾病状态的方法.

专利信息

专利号:US-9944644-B2
优先权日:2013-03-14
标 题 :Octahydropyrrolopyrroles their preparation and use
发明人：PETRUKHIN KONSTANTIN; CIOFFI CHRISTOPHER; JOHNSON GRAHAM; DOBRI NICOLETA; FREEMAN EMILY; CHEN PING; CONLON MICHAEL; ZHU LEI
权利人:PETRUKHIN KONSTANTIN; CIOFFI CHRISTOPHER; JOHNSON GRAHAM; DOBRI NICOLETA; FREEMAN EMILY; CHEN PING; CONLON MICHAEL; ZHU LEI; UNIV COLUMBIA
摘要:The present invention provides compounds comprising variously substituted octahydropyrrolopyrroles, their synthesis, methods of making, methods of using, compositions and formulations thereof.