CAS: 161321-36-4; Fmoc-Chg-Oh

相似化合物

198543-96-3 186320-22-9 109183-71-3

上下游产品

(fluorenylmethoxy)carbonyl chloride (2S)-amino(cyclohexyl)ethanoic acid N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

氯甲酸-9-芴基甲酯,L-环己基甘氨酸置于sodium Carbonate体系中,用 水,1,4-二氧六环 用作溶剂,化学反应 8.0H,反应生成芴甲氧羰酰基环己基甘氨酸
参考文献:天然和设计的微管溶素的全合成和生物学评价
标题:天然和设计的微管溶素的全合成和生物学评价
摘要:描述了基于 Ch 激活策略的 N(14)-去乙酰氧基微管溶素 H (Tb1) 的简化全合成和 Pretubulysin D (Ptb-D43) 的短全合成.还报告了所开发的合成策略和技术在合成一系列微管溶素类似物(tb2-Tb41 和 Ptb-D42)中的应用.针对一系列癌细胞的合成化合物的生物学评估揭示了许多新的类似物(例如,Tb14),其中一些对某些细胞系具有特殊的效力[例如,Tb32 对 Mes Sa(子宫肉瘤)细胞系的 Ic50 = 12 Pm和 2 Pm 针对 Hek 293T(人胚胎肾)细胞系],以及一组有价值的构效关系.
Doi:10.1021/jacs.5B12557

专利信息

专利号:US-11472838-B2
优先权日:2018-04-17
标 题:Inhibitors of blood coagulation factor XIII
发明人：HILS MARTIN; PASTERNACK RALF; BÃœCHOLD CHRISTIAN
权利人:ZEDIRA GMBH
摘要:The invention relates to a compound of general formula (I) as novel inhibitor of blood coagulation factor XIII, methods for synthesis thereof and to use thereof for the prophylaxis or treatment of diseases associated with blood coagulation factor XIII.

专利号:US-2024124517-A1
优先权日:2020-12-25
标题:Method for producing peptide compound containing n-substituted-amino acid residue
发明人：MORITA YUYA; NOMURA KENICHI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:An object of the present invention is to provide a method for efficiently producing a high-purity peptide compound with a high yield. It has been found that the object can be achieved by supporting a peptide on a solid phase synthesis resin prior to a first elongation reaction in a solid phase process.