CAS: 25185-95-9; 2,6-Dichlorobenzaldehyde Oxime

上下游产品

CAS号83-38-5 2,6-二氯苯甲醛 | CAS号4402-83-9 3-(2,6-二氯苯基)-5-... | CAS号50907-31-8 5-(2,6-二氯苯基)-1H-四唑 | CAS号3919-76-4 3-(2,6-二氯苯基)-5-... | CAS号50-30-6 2,6-二氯苯甲酸 | CAS号4462-55-9 3-(2,6-二氯苯基)-5-... | CAS号2904-62-3 2,6-dichloroben... | CAS号278597-32-3 2-氯-4-[[3-(2,6-... | CAS号24248-21-3 3-(2,6-二氯苯基)-5-... | CAS号278597-28-7 3-(2,6-二氯苯基)-5-... | CAS号2008-58-4 2,6-二氯苯甲酰胺

2,6-二氯苯甲酸置于n-甲基吗啉,Bis-Triphenylphosphine-Palladium(II) Chloride,二甲基苯基硅烷,羟胺体系中,用 水,甲苯 用作溶剂,化学反应 13.0H,反应生成2,6-二氯苯甲醛肟
参考文献:在氢硅烷存在下通过钯催化的c-O / C-N键裂解获得醛的策略
标题:在氢硅烷存在下通过钯催化的c-O / C-N键裂解获得醛的策略
摘要:我们报告了选择性的c(酰基)-X(x = O,N)裂解,通过钯催化的方法获得醛官能团,从而催化活性酯和酰胺的催化还原.氢化硅烷作为还原剂可以促进反应,其收率好至极好,并且对c(酰基)-N和c(酰基)-O键的裂解具有出色的化学选择性.羧酸的c(酰基)-O键被2-氯-4,6-二甲氧基-1,3,5-三嗪(cdmt)活化形成三嗪酯中间体,该中间体进一步与氢硅烷反应在一个锅中生成醛两步过程.我们证明,与在相同反应条件下进行c(酰基)-N裂解相比,C(酰基)-O裂解/甲酰化可提供更高的收率和更宽的底物范围.
Doi:10.1002/adsc.202000794

专利信息

专利号:US-8952042-B2
优先权日:2009-08-19
标 题 :FXR (NR1H4) binding and activity modulating compounds
发明人：KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF
权利人:KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF; PHENEX PHARMACEUTICALS AG
摘要:The present invention relates to compounds of formula (1): n nwhere R, A, Q and Z are defined herein, or an enantiomer, diastereomer, tautomer, solvate, prodrug or pharmaceutical acceptable salt thereof. These compounds bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.

专利号:CN-109174200-A
优先权日:2018-09-04
标 题:A kind of catalyst, preparation method and synthesis method for synthesizing 1,1-diethoxyethane