CAS: 39895-56-2; (4-(Aminomethyl)Phenyl)Methanol

该化合物是一种双功能有机化合物,其特点是氨基甲基(-CH2NH2)和联苯环的氢氧甲基(-CH2OH)组. 这一结构将多功能作为有机合成的一块基石,特别是药品,农用化学品和特殊聚合物. 主要的安咪和氢氧化物组为进一步功能化提供了反应场所,使交叉连接,凝聚或作为热循环形成中间体的应用成为可能. 它的平衡极极性提高了极地溶剂的溶解性,便利了水或有机反应系统的处理. 该化合物在标准条件下的稳定性和与共同保护组战略的兼容性使得它成为多步合成途径的一个实际选择.

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CAS号874-89-5 羟甲基 | CAS号56-91-7 氨甲苯酸 | CAS号439691-96-0 (4-(azidomethyl... | CAS号105-07-7 对氰基苯甲醛 | CAS号6232-11-7 4-氨甲基苯甲酸甲酯盐酸盐 | CAS号1129-35-7 对氰基苯甲酸甲酯 | CAS号17201-43-3 α-溴对甲基苯甲腈 | CAS号6757-31-9 4-氨基甲酰苯甲酸甲酯 | CAS号1679-64-7 对苯二甲酸单甲酯 | CAS号33233-67-9 4-[(叔丁氧羰基氨基)甲基]苯甲酸 | CAS号176504-01-1 Fm°C-(4-氨基甲基苯基)乙酸 | CAS号187283-17-6 4-(溴甲基)苄基氨基甲酸叔丁酯 | CAS号874-89-5 羟甲基 | CAS号674799-96-3 6-[[4-(氨基甲基)苯基]... | CAS号1007859-08-6 4-(羟基甲基)苄基氨基甲酸烯丙酯 | CAS号159730-67-3 benzyl 4-formyl... | CAS号123986-64-1 4-(羟甲基)苄基氨基甲酸叔丁酯 | CAS号178053-18-4 N-b°C-4-氨基甲基苄氯 | CAS号171723-95-8 2,2,2-三氟-N-(4-(...

合成工艺路线路线简述

  • 合成目标产物 (4-Aminomethyl-Phenyl)-Methanol 主要起始原料 Methyl 4-Cyanobenzoate
  • (文献来源)合成步骤主要原料 Methyl 4-Cyanobenzoate
4-溴甲基苯甲醛置于甲醇,Sodium Tetrahydroborate,Sodium Azide,三苯基膦体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 3.0H,反应生成 4-胺甲基苯甲醇
参考文献: Glucose Sensor Molecule[fr] Molécule Pour Détecteur De Glucose
标题: Glucose Sensor Molecule[fr] Molécule Pour Détecteur De Glucose
摘要:本发明提供了一种葡萄糖传感器,该传感器具有含有公式(i)的键合位的葡萄糖受体:其中x,N,M和r1的定义如本文所述.还提供了一种用于此类葡萄糖传感器的葡萄糖传感器分子,该葡萄糖传感器分子含有公式(i)的键合位.已经发现,该键合位对葡萄糖具有特别好的选择性.

海关参考信息

专利信息


专利号:US-7799524-B2
优先权日:2002-10-03
标 题:Substrates for O6-alkylguanina-DNA alkyltransferase
发明人:KINDERMANN MAIK; JOHNSSON KAI; BIERI CHRISTOPH
权利人:ECOLE POLYTECHNIQUE FERDEALE D
摘要:The invention relates to compounds of formula 1 n nwherein R 1 -R 2 is a guanine derivative; X is oxygen or sulfur; R 3 is a heteroaromatic, unsaturated heterocyclyl or an alkynyl group with the double or triple bond connected to CH 2 ; R 4 is a linker; and L is a label, a plurality of same or different labels, a bond connecting R 4 to R 1 forming a cyclic substrate, or a further group —R 3 —CH 2 —X—R 1 -R 2 . The invention relates also to methods of manufacture of such novel AGT substrates, to intermediates useful in the synthesis of such AGT substrates, and to a method of transferring a label from such AGT substrates to O 6 -alkylguanine-DNA alkyltransferase (AGT) fusion proteins comprising proteins of interest.

专利号:US-6762281-B2
优先权日:2000-09-08
标题:Process for preparing peptide derivatized oligomeric compounds
发明人:MANOHARAN MUTHIAH; GUZAEV ANDREI P
权利人:ISIS PHARMACEUTICALS INC
摘要:Methods of preparing peptide linked oligomeric compounds are provided. The method is useful for preparing larger scale amounts of peptide linked oligomeric compounds. More particularly, the synthesis of peptide linked oligomeric compounds is performed without the problems of aggregation associated with electrostatic interactions. The present method describes using equimolar amounts of oligomeric compounds and peptide reagents providing for an increase in overall efficiency.

专利号:US-11511238-B1
优先权日:2021-07-20
标 题 :Composite covalent organic framework membranes
发明人:BIKSON BENJAMIN
权利人:Avanpore LLC
摘要:Disclosed is the preparation of composite fluid separation membranes based on poly (aryl ether ketone) (PAEK) polymers with the separation layer formed by a layer-by-layer reticular synthesis. The porous PAEK substrate is semicrystalline, exhibits a mesoporous surface structure, and is surface functionalized. The separation layer formed by the hierarchical layer-by-layer process is in the form of a covalent organic network integrally linked via covalent bonds to the functional groups of the substrate. The composite separation layer may be synthesized in situ in a preformed separation device on the surface of the PAEK substrate. Device configurations include flat sheet, spiral wound, monolith, and hollow fiber configurations with the hollow fiber configuration being preferred. Hollow fibers are formed from PAEK polymers with poly (ether ether ketone) and poly (ether ketone) particularly preferred. Composite PAEK membranes of the present invention are useful for a broad range of fluid separation applications.

专利号:US-9670305-B2
优先权日:2012-04-16
标 题 :Polyurethane dispersant and the method for its preparation
发明人:WANG ZHIJUN
权利人:WANG ZHIJUN; AFCONA CHEMICALS (HAIMEN) CO LTD
摘要:The present invention is related to a polyurethane dispersant and a preparation method thereof. The polyurethane dispersant is terminated by a nitrogen-containing heterocyclic compound during synthesis. The nitrogen-containing heterocyclic compound is prepared by subjecting anhydride and a compound containing a primary amine and a secondary amine or a hydroxyl or mercapto group to dehydration condensation. The condensed product is the nitrogen-containing heterocyclic compound, containing a reactive hydrogen. The structural formula of the compound containing the primary amine and the secondary amine or hydroxyl or mercapto group is shown as follows: n nwherein n=1 to 5, and preferably 2 to 4, R 1 and R 2 are respectively alkyls containing 1 to 8 carbons, R 1 and R 2 are independent of each other or connected by a chemical bond to form one or more saturated or unsaturated 4-member to 8-member rings, and X represents N, O, or S.

专利号:US-2021093737-A1
优先权日:2013-03-15
标题 :Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors

专利号:CN-104031048-B
优先权日:2014-05-28
标题 :A kind of β-chloroethylnitrosourea compound and its synthesis method and application
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合成参考文献


摘要:Harnying, W.; Berkessel, A., Science of Synthesis: Knowledge Updates, (2024) 1, 361.
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