专利号:US-7811612-B2 优先权日:2005-01-20 标 题 :Herbal mixture extract of notoginseng radix, rehmanniae radix preparata and acanthopanacis cortex and composition comprising the same for prevention and treatment of arthritis 发明人:KIM JUNG-KEUN; KIM SE-WON; KIM HYUNG-GUN; KO SEON-YLE; BAEK DONG-HEON; CHANG SUNHWA 权利人:OSCOTEC INC 摘要:The present invention relates to an extract of an herbal mixture of Notoginseng radix, Rehmanniae radix preparata and Acanthopanacis cortex , and a method for treating arthritis using the extract as an effective ingredient. The extract of the herbal mixture of the present invention can effectively inhibits the release of inflammatory substances and the synthesis of cartilage destroying substance as well as the progress of arthritis.
专利号:WO-2023249340-A1 优先权日:2022-06-20 标 题 :High-purity ginseng exosome composition and use thereof in functional cosmetics 发明人:CHO YONG WOO; CHOI JI SUK; CHOI YOUNG CHAN; LEE HYE RI 权利人:EXOSTEMTECH CO LTD; IUCF HYU ERICA CAMPUS 摘要:The present invention relates to a functional cosmetic composition comprising plant exosomes derived from ginseng as its active ingredient, and functional cosmetics containing same. Ginseng exosomes have a bilipid layer structure and are rich in ginsenosides Rb1 and Rg1, which influence skin improvement and whitening. It has been proven that these powerful functional materials, ginsenosides Rb1 and Rg1, are absorbed in large quantities through ginseng exosomes into skin cells, enhance the synthesis of collagen and hyaluronic acid in skin cells, and have the efficacy of inhibiting melanin synthesis. Therefore, the ginseng exosomes rich in ginsenosides Rb1 and Rg1, as presented in the present invention, can be beneficially used in functional cosmetic compositions for skin aging prevention, skin whitening, wrinkle reduction, and skin cell regeneration.
专利号:US-2007060499-A1 优先权日:2005-09-15 标 题 :Chloroquine combination drugs and methods for their synthesis 发明人:KOSAK KENNETH M 权利人:KOSAK KENNETH M 摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.
专利号:ES-2209197-T3 优先权日:1997-08-08 标 题 :USE OF GINSENOSIDE RB1 TO STIMULATE THE SYNTHESIS OF ELASTINE.
专利号:CN-117683794-A 优先权日:2024-02-04 标题 :PgCOMT2 gene for promoting synthesis of melatonin and ginsenoside in ginseng and application thereof
专利号:CN-113598003-A 优先权日:2021-09-15 标题:A kind of method and application of improving the synthesis of Panax notoginseng saponins
1: Shen L, Haas M, Wang DQ, May A, Lo CC, Obici S, Tso P, Woods SC, Liu M. Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats. Physiol Rep. 2015 Sep;3(9). pii: e12543. doi: 10.14814/phy2.12543.
合成参考文献
参考文献:10.5281/zenodo.5794106 摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106