CAS: 611-21-2; N,2-Dimethylaniline

上下游产品

CAS号609-72-3 N,N-二甲基邻甲苯胺 | CAS号126799-83-5 1-(叠氮甲基)-2-甲基苯 溶液 | CAS号68-11-1 硫代乙醇酸(TGA) | CAS号94-69-9 2'-甲基甲酰苯胺 | CAS号77-78-1 硫酸二甲酯 | CAS号120-66-1 乙酰邻甲苯胺 | CAS号95-46-5 2-溴甲苯 | CAS号74-89-5 氨基甲烷 | CAS号59557-89-0 N-甲基-4-溴-2-甲基苯胺 | CAS号120-72-9 吲哚 | CAS号95-53-4 邻甲苯胺 | CAS号3558-24-5 N-甲基-2-苯基吲哚 | CAS号95-68-1 2,4-二甲基苯胺 | CAS号875-79-6 1,2-二甲基吲哚 | CAS号609-72-3 N,N-二甲基邻甲苯胺 | CAS号61-70-1 N-甲基-N-氧化吗啉 | CAS号1197-42-8 4-Methylamino-3... | CAS号1821-38-1 (2-Ethylphenyl)...

1,3-Dimethyl-1,3-Di-O-Tolylurea置于盐酸体系中,化学反应生成 N-甲基-邻甲基苯胺
参考文献:Rassow; Reuter,Journal Fur Praktische Chemie (Leipzig 1954),1912,Vol. <2>85,P. 492
标题:Rassow; Reuter,Journal Fur Praktische Chemie (Leipzig 1954),1912,Vol. <2>85,P. 492

专利信息

专利号:US-11325912-B2
优先权日:2019-05-09
标题 :Regio-selective synthesis of imidazo[1,2-a]pyrimidines
发明人：CLAGG KYLE BRADLEY PASCUAL; WHITE NICHOLAS ANDREW; ZHANG HAIMING; GOSSELIN FRANCIS; NACK WILLIAM; O'SHEA PAUL D
权利人:GENENTECH INC
摘要:A method of regio-selectively synthesizing an imidazo-pyrimidine compound of formulae (XXa) or (XXb)comprising a step of coupling a first compound of formula XX-P1a or XX-P1b with a second compound of formula XX-P2This annulation reaction between β-ethoxy acrylamides and phosphorylated aminoimidazoles to furnish imidazo[1,2-a]pyrimidin-amines relies on steering effects from endocyclic and exocyclic phosphorylated aminoimidazoles. The reaction furnishes either 2-amino or 4-amino constitutional isomers of imidazo[1,2-a]pyrimidines with good yields and ranges of 90:10-99:1 regio-selectivity. The reaction is useful in the synthesis of various tracer molecules used in the study of neurological conditions such as where R3 and R4 together with the imidazole ring atoms to which they are bonded form a phenyl ring and the products are substituted benzimidazopyrimidines. The reaction can be generalized to form imidazo[1,2-a]pyrimidines substituted at either of their 2- and 4-positions by alkoxy or thioalkyl groups.

专利号:US-7193039-B2
优先权日:1999-12-22
标题:Synthesis of a potent parmagnetic agonist (epm-3) of the melanocyte stimulating hormone containing amino acid-type stable free radical
发明人：NAKAIE CLOVIS RYUICHI; BARBOSA SIMONE DOS REIS; CILLI EDUARDO MAFFUD; LAMY-FREUND MARIA TEREZA; SIUITI ITO ARMANDO; VISCONTI MARIA APARECIDA; CASTRUCCI ANA MARIA DE LAURO
权利人:CONSELHO NACIONAL CNPQ
摘要:The present invention refers to the chemical synthesis and potentiality for application in several biochemical assays, of a potent agonist of the α-melanocyte stimulating hormone (α-MSH), labeled with an amino acid-type paramagnetic spin probe (Toac, or 2,2,6,6-tetramethylpiperidine-1-oxyl-amino-4-carboxylic acid), valuable for use in electron spin resonance and fluorescence allowing biochemical-clinical investigation of relevant physiological roles of α-MSH in animal organism. The referred analogue of the present invention, acetil-Toac 0 -(Nle 4 , DPhe 7 )-α-MSH, where (Nle 4 , DPhe 7 )-α-MSH is nominated commercially as Melanotanâ„¢ and although containing a non-natural compound in its structure such as Toac, maintained entirely its potent agonist potency. Its integral activity associated with the fact that it is naturally fluorescent (due to the Trp residue of its sequence) give to this labeled analogue a unique potential for a great variety of investigations regarding relevant physiological roles already known of this neuroimmuno-modulator.

专利号:US-4092329-A
优先权日:1972-12-01
标 题:Process for the synthesis of certain 2-amino-5-cyanothiophenes
发明人：JOTTERAND ARMAND
权利人:SANDOZ LTD
摘要:The invention relates to a process which comprises reacting a compound of formula I, ##STR1## in which A 1 is a radical which does not compete with the activity of the ##STR2## OR A TAUTOMER THEREOF, WITH A COMPOUND OF FORMULA II, n n a.sub.2 -- ch.sub.2 -- cn ii n n in which A 2 is a radical which does not compete with the activity of the --CH 2 CN group of the compound of formula II but provides the vicinal methylene group with sufficient acidity to react with the â•?NH group of the compound of formula I, n and with sulphur, n To obtain a compound of formula III, ##STR3## in which A 1 and A 2 are as defined above, which compounds of formula III are useful as intermediates for the production of dyestuffs.

专利号:US-8933227-B2
优先权日:2009-08-14
标题 :Selective synthesis of functionalized pyrimidines
发明人：LINZ GUENTER; KRAEMER GERD; KUSSEROW SABRINA; SCHNAUBELT JUERGEN
权利人:LINZ GUENTER; KRAEMER GERD; KUSSEROW SABRINA; SCHNAUBELT JUERGEN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to a process for making 2,4-differentiated 5-trifluoromethyl pyrimidines and 2-amino-5-trifluoromethyl-pyrimidine derivatives, which compounds are useful in the preparation of pharmacologically active compounds.

专利号:US-8981092-B2
优先权日:2008-09-19
标题 :Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity
发明人：MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO
权利人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds, n nor pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:US-6479668-B1
优先权日:1998-09-08
标 题 :Method of producing pyrrolidine derivatives
发明人：MURAOKA HIDEO; SATO HARUYO
权利人:TORAY INDUSTRIES
摘要:A method for producing pyrrolidine derivatives such as 3,4-epoxypyrrolodines, 3-pyrrolidols and the like, by oxidizing 3-pyrrolines with at least one peroxide in the presence of at least one acid is disclosed. The 3-pyrrolines are produced by deriving cis-2-butene compounds from cis-2-butene-1,4-diols and performing a cyclization between the cis-2-butene derivatives and at least one primary amine. The method may be performed as a one-pot synthesis and may be performed as a continuous reaction.