专利号:US-10604599-B2 优先权日:2018-05-29 标题:Method for green synthesis of uniform- and large-particle-size polystyrene particles 发明人:SHUANG CHENDONG; ZHOU WEIWEI; WANG YUNSHU; LI AIMIN; LI QIMENG; LIU LILI; WANG WEI; ZHANG YI 权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING UNIV & YANCHENG ACADEMY OF ENVIRONMENTAL PROTECTION TECHNOLOGY AND ENGINEERING 摘要:A method for green synthesis of uniform- and large-particle-size polystyrene particles, comprising steps of: prepolymerizing styrene at 70â–¡ to 75â–¡ for 1 h to 6 h in advance while stirring, adding divinylbenzene dissolved with initiators to the styrene, and stirring for 10 min to 30 min to obtain oil phase; heating lactic acid or an aqueous solution of lactic acid to 70â–¡ to 80â–¡, adding the oil phase to dispersed phase by a constant-pressure device, maintaining the temperature for 2 h, heating to 80±5â–¡ and then maintaining the temperature for 1 h, and heating to 85±5â–¡ and then maintaining the temperature for 3 h to 6 h, to obtain polystyrene particles with a uniform particle size ranging from 0.7 mm to 2.0 mm.
专利号:US-2019047933-A1 优先权日:2016-03-15 标 题:Process for the synthesis of (2e, 4e, 6z, 8e)-8-(3,4-dihydronaphthalen-1(2h)-ylidene)-3,7-dimethylocta-2, 4, 6-trienoic acid 发明人:ABEL ULRICH; RÉPÃ?SI JÓZSEF; Szabó András; SZÜCSNÉ CSERÉPI STEFÃ?NIA; Bor Ã?dám 权利人:ABEL ULRICH; REPASI JOZSEF; SZABO ANDRAS; SZUECSNE CSEREPI STEFANIA; BOR ADAM; BRICKELL BIOTECH INC 摘要:This invention relates to a novel method for the synthesis of (2E,4E,6Z,8E)-8-(3,4-dihydronaphthalen-1(2H)-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid. In particular, the invention relates to several improvements in several individual steps of the multi-step synthesis scheme
专利号:WO-2024105700-A1 优先权日:2022-11-18 标 题:A method for the synthesis of anthranilic amide compounds and intermediates thereof 发明人:MALVIYA NITIN; MAL SANJIB; KLAUSENER ALEXANDER G M 权利人:PI INDUSTRIES LTD 摘要:The present invention discloses a method for the synthesis of a compound of formula (V) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The method further comprises the synthesis of an anthranilic diamide compound of formula (Z).
专利号:US-11719709-B2 优先权日:2020-02-14 标题 :Water soluble polymer surfactant for synthesis of functionalized polystyrene nanobeads towards detection of bilirubin in human serum 发明人:MAKKAD SARABJOT KAUR; SYAMAKUMARI ASHA 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides a water soluble polymer surfactant (PS-DGlu) of formula I which is utilized for synthesis of functionalized polystyrene nanobead covalently incorporating (oligo) p-phenylenevinylene (OPV) nanosensor (PSG-OPV-n) which in turn is useful for the detection of bilirubin in human serum. The present invention further provides a process for the preparation of the water soluble polymer surfactant (PS-DGlu) of formula (I) and a mini emulsion polymerization process for the synthesis of PSG-OPV-n.wherein, n is 30-50.The PSG-OPV-n nanosensor beads show selectivity towards detection of bilirubin in presence of interferences such as glucose, sucrose, metal ions, cholesterol, and biliverdin with limit of detection of 20 nM. Ultimately, the invention also provides a kit for visual detection of bilirubin in human serum.
专利号:US-12410140-B2 优先权日:2020-06-19 标题:Method for synthesis of roxadustat and intermediate thereof, and intermediate thereof 发明人:ZHANG YONG; WANG GUO; YANG FEI; LIU FENGWEI; ZHOU CHUNDONG; ZHANG ZITONG 权利人:JUMPCAN SHANGHAI MEDICAL TECH CO LTD 摘要:Disclosed are a method for the synthesis of roxadustat and an intermediate thereof, and an intermediate thereof. In particular, disclosed is a method for the synthesis of compound M1, the method comprising the following steps: carrying out a reaction as shown below between compound SM and compound SM-A under the action of an oxidizing agent. The method of the present invention uses cheap and easily available raw materials, has short reaction steps, produces a high yield, has simple and convenient post-treatment procedures, and is suitable for industrial production.
专利号:US-6512081-B1 优先权日:1997-07-21 标题:Synthesis of dithioester chain transfer agents and use of bis(thioacyl) disulfides or dithioesters as chain transfer agents 发明人:RIZZARDO ENZIO; THANG SAN HOA; MOAD GRAEME 权利人:E I DUPONT NEMOURS AND COMPANY; COMMW SCIENT IND RES ORG 摘要:This invention relates to the synthesis of dithiocarboxylic acid esters by reaction of bis(thioacyl) disulphides, thioacetals or vinylidane bis(thioether) with free-radicals (optionally in the presence of monomers). The invention also relates to processes for the synthesis of polymers utilising these dithioesters as polymerisation regulators (chain transfer agents) or to the use of bis(thioacyl) disulphides to generate dithioester chain transfer agents in situ.
参考文献:10.2147/ccid.s13873 摘要:Feneran AN, Kaufman WS, Dabade TS, Feldman SR. Retinoid plus antimicrobial combination treatments for acne. Clin Cosmet Investig Dermatol. 2011;4():79–92. 参考文献:10.1111/j.1365-3164.2011.01002.x 摘要:Young R, Buckley L, McEwan N, Nuttall T. Comparative in vitro efficacy of antimicrobial shampoos: a pilot study. Vet Dermatol. 2012 Feb;23(1):36–40, e8. doi: 10.1111/j.1365-3164.2011.01002.x.