专利号:US-6204337-B1 优先权日:1996-11-19 标 题:Solid-phase synthesis of codeine from morphine 发明人:CORCORAN ROBERT C; MA JUNNING 权利人:UNIV COMMUNITY COLLEGE SYS NEV 摘要:The specification describes a methylation resin comprising methyl(dialkyl)anilinium salts or methyl(diaryl)anilinium salts covalently bonded to the resin. The methylation resin is used in the solid-phase synthesis of codeine from morphine. Accordingly, the specification describes a process for methylating morphine to form codeine by loading morphine onto a methylation resin comprising methyl(dialkyl)anilinium salts or methyl(diaryl)anilinium salts covalently bonded to the resin; contacting the loaded resin with sufficient hydrocarbon or ether solvent to cover the loaded resin; and heating the loaded resin in the hydrocarbon or ether solvent under sufficient conditions to form codeine. The methylating resin may be used to methylate phenolic moieties on other compounds and to esterify compounds containing carboxylic acid moieties.
专利号:US-5981750-A 优先权日:1995-11-21 标 题 :Solid-phase synthesis of codeine from morphine 发明人:CORCORAN ROBERT C; MA JUNNING 权利人:UNIV COMMUNITY COLLEGE SYS NEV 摘要:The specification describes a methylation resin comprising methyl(dialkyl)anilinium salts or methyl(diaryl)anilinium salts covalently bonded to the resin. The methylation resin is used in the solid-phase synthesis of codeine from morphine. Accordingly, the specification describes a process for methylating morphine to form codeine by loading morphine onto a methylation resin comprising methyl(dialkyl)anilinium salts or methyl(diaryl)anilinium salts covalently bonded to the resin; contacting the loaded resin with sufficient hydrocarbon or ether solvent to cover the loaded resin; and heating the loaded resin in the hydrocarbon or ether solvent under sufficient conditions to form codeine. The methylating resin may be used to methylate phenolic moieties on other compounds and to esterify compounds containing carboxylic acid moieties.
专利号:US-6229055-B1 优先权日:1996-04-12 标题 :Synthesis of fluorinated xanthene derivatives 发明人:KLAUBERT DIETER H; GEE KYLE R 权利人:MOLECULAR PROBES INC 摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.
专利号:US-2016318862-A1 优先权日:2013-09-25 标 题:Synthesis of delta 12-pgj3 and related compounds 发明人:NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES 权利人:UNIV RICE WILLIAM M 摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.
专利号:WO-9509170-A1 优先权日:1993-09-28 标 题:Chemical synthesis of rhodamine derivatives 发明人:CORRIE JOHN EDGAR THOMAS; CRAIK JAMES STANLEY 权利人:MEDICAL RES COUNCIL; CORRIE JOHN EDGAR THOMAS; CRAIK JAMES STANLEY 摘要:A method for preparing rhodamine derivatives of formulae (a) or (b) or a mixture of such compounds, where X is bromo, chloro- or iodoacetamido, maleimido, or amino. These compounds are the 5 and 6 (or 5' and 6') isomers of the amine, haloacetamide and maleimide derivatives of tetramethylrhodamine. The method enables for the first time the production of isomerically pure compounds on a relatively large scale. The products are fluorescent and are useful for the labelling of proteins.
专利号:US-9035070-B2 优先权日:2010-07-30 标 题 :Process for the preparation of 1-aryl-pyrazol-3-one intermediates useful in the synthesis of sigma receptors inhibitors 发明人:BARTRA SANMARTI MARTÃ?; BERENGUER MAIMO RAMON; MEDRANO RUPEREZ JORGE; GARCIA GOMEZ JORGE; ARIZA PIQUER JAVIER 权利人:BARTRA SANMARTI MARTÃ?; BERENGUER MAIMO RAMON; MEDRANO RUPEREZ JORGE; GARCIA GOMEZ JORGE; ARIZA PIQUER JAVIER; ESTEVE QUÃ?MICA S A 摘要:The invention relates to a process for preparing 1-aryl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.
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