CAS: 1125-60-6; Isoquinolin-5-Amine

相似化合物

607-32-9 23707-37-1 23687-26-5

上下游产品

5-amino-1-chloroisoquinoline 5-nitroisoquinoline 5-Nitroisoquinoline N-Oxide 5-hydroxyisoquinoline N-(isoquinolin-5-yl)acetamide N-acetyl-sulfanilic acid-[5]isoquinolylamideN-acetyl-sulfanilic acid-[5]isoquinolylamide 5-hydroxyisoquinoline 1-(5-isoquinolinyl)thioureaN-phenyl-N1-(5-isoquinolinyl)thiourea

5-硝基异喹啉置于v2O5/tio2,一水合肼体系中,用 乙醇 用作溶剂,以91 %的收率获得5-氨基异喹啉
参考文献:可见光下非均相 V2O5/tio2 介导的硝基化合物光催化还原为相应的胺
标题:可见光下非均相 V2O5/tio2 介导的硝基化合物光催化还原为相应的胺
摘要:在环境温度下,在蓝色 Led (9 W) 照射下,使用非均相且可回收的催化剂 (V 2 O 5 /tio 2 ) 将硝基化合物氢化成相应的胺.采用水合肼作为还原剂,乙醇作用作溶剂,促进绿色,可持续,低成本生产.描述了 32 种(杂)芳胺及其药学相关分子(五种)的合成.该协议的显着特点包括催化剂可回收性,绿色溶剂,环境温度和克级反应.研究的其他方面包括1H-NMR 辅助反应进程监测,机理研究的控制实验,方案应用和可回收性研究.此外,所开发的方案实现了广泛的官能团耐受性,化学选择性,高产率,低成本,可持续且环境友好的合成.
Doi:10.1021/acs.Joc.3C00569

专利信息

专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人：HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-8058477-B2
优先权日:2006-03-21
标 题 :Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
发明人：HARTWIG JOHN F; SHEN QILONG
权利人:HARTWIG JOHN F; SHEN QILONG; UNIV YALE
摘要:A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.

专利号:US-9840468-B1
优先权日:2016-12-30
标 题:Methods for the preparation of 6-aminoisoquinoline
发明人：CHAMBOURNIER GILLES; DELONG MITCHELL A
权利人:AERIE PHARMACEUTICALS INC
摘要:Described are methods for the preparation of 6-aminoisoquinoline, a useful intermediate compound in the synthesis of kinase inhibitors.

专利号:US-5656634-A
优先权日:1991-03-21
标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
发明人：CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J
权利人:PFIZER
摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-2008114172-A1
优先权日:2006-11-09
标 题 :Synthesis of Selected Stereoisomers of Certain Substituted Alcohols