CAS: 122-34-9; Simazine

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CAS号108-77-0 氰尿酰氯 | CAS号75-04-7 乙胺 | CAS号504-08-5 2,4-二氨基-1,3,5-三嗪 | CAS号860473-84-3 N-[6-(ethylamin... | CAS号2599-11-3 西玛津-2-羟基 | CAS号914486-10-5 N-(6-acetamido-... | CAS号7313-54-4 去异丙基-2-羟基莠去津 | CAS号1007-28-9 氟氯氢菊脂 | CAS号673-04-1 西玛通 | CAS号645-92-1 三聚氰酸二酰胺 | CAS号16268-92-1 N2,N4,N6-三乙基-1,... | CAS号6494-81-1 N-NITROSOSIMAZINE

三聚氯氰,乙胺置于碳酸氢钠体系中,用 丙酮 用作溶剂,化学反应生成西玛津
参考文献:杂化吡唑取代的 1,3,5-三嗪衍生物的设计,计算机研究,合成和抗疟活性评价
标题:杂化吡唑取代的 1,3,5-三嗪衍生物的设计,计算机研究,合成和抗疟活性评价
摘要:疟疾是一个重大的全球健康挑战,特别是在非洲,亚洲和拉丁美洲,需要立即研究创新和有效的治疗方法.这项工作涉及开发吡唑取代的 1,3,5-三嗪衍生物作为抗疟剂.本研究利用亲核取代反应合成了10种化合物(-),进行了筛选研究,并评估了它们对3D7(氯喹敏感)菌株的抗疟活性.目前的工作涉及杂化三甲氧基吡唑1,3,5-三嗪衍生物的开发.通过分析,确定了四种具有非常好结合能和码头分数的化合物.对接研究的主要重点是检查氢键以及与某些氨基酸残基的相关相互作用,包括 Arg A122,Ser A108,Ser A111,Ile A164,Asp A54 和 Cys A15.测量了四种化合物的 Ic50 值,以评估它们对氯喹敏感 3D7 菌株的抗疟活性. Ic 值范围为 25.02 至 54.82 μg/ml.在这十种衍生物中,该化合物作为抗疟剂具有相当大的潜力,使其成为药物探索领域进一步完善的可行竞争者,其目的是减轻全球疟疾负担.
Doi:10.1016/j.Exppara.2024.108767

专利信息

专利号:US-4774173-A
优先权日:1984-12-06
标 题 :Microbiological assay kit and method for detecting de novo biomolecular synthesis inhibitors
发明人：REINHARTZ AVRAHAM
权利人:ORGENICS LTD
摘要:A method for assaying a specimen for the presence of a substance capable of inhibiting de novo biomolecular synthesis in a test microorganism, which comprises: exposing a cell wall permeability-enhanced test microorganism exhibiting delayed de novo synthesis of said biomolecule to said specimen, and assaying the extent of inhibition of synthesis of said biomolecule in said microorganism. A kit is described for performing the method, as well as a reaction mixture for performing the technique.

专利号:US-8192762-B2
优先权日:2005-06-01
标题 :Preparation of soluble and colloidal molecularly imprinted polymers by living polymerization
发明人：KARIM KHALKU; PILETSKY SERGEY ANATOLIYOVICH; PILETSKA OLENA VOLODIMIRIVNA; TURNER ANTHONY PETER FRANCIS; CHIANELLA IVA; GUERRIERO ANTONIO RICARDO LEONARDO
权利人:KARIM KHALKU; PILETSKY SERGEY ANATOLIYOVICH; PILETSKA OLENA VOLODIMIRIVNA; TURNER ANTHONY PETER FRANCIS; CHIANELLA IVA; GUERRIERO ANTONIO RICARDO LEONARDO; UNIV CRANFIELD
摘要:The present invention describes a method for synthesis of relatively low molecular weight imprinted polymers using living polymerization, and their application in analytical chemistry, pharmacology, medicine and the food industry. Specifically the low-molecular weight polymers are synthesized by the polymerization of functional monomers in the presence of a template, such as a biological receptor, enzyme, nucleic acid, cell, virus, microorganism, tissue sample or drug using living initiator. The conditions of living polymerization ensure a relatively small size of synthesized molecules. Synthesized in this way molecules (dimers, oligomers, polymers, or their mixture) have a higher affinity to the template than the original monomers and can rebind it in vitro and/or in vivo. As a further aspect of the present invention, polymers synthesized as described above can be used as drugs in pharmacology and medicine, as receptor-specific ligands in analytical chemistry (sensors, assays), and for separations in the biotechnology, pharmaceutical and food industries.

专利号:WO-2024256370-A1
优先权日:2023-06-13
标 题 :Synthesis of glufosinate using an amidase-based process
发明人：ZIMMERMANN GUNTHER; POTT MORITZ STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.

专利号:US-2025120400-A1
优先权日:2021-12-10
标题:Synthesis of glufosinate using a hydantoinase-based process
发明人：DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.

专利号:US-8895747-B2
优先权日:2009-07-27
标 题 :Method and substances for preparation of N-substituted pyridinium compounds
发明人：HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL
权利人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL; ROCHE DIAGNOSTICS OPERATIONS
摘要:Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.

专利号:US-11919928-B2
优先权日:2016-03-16
标题 :Method for producing dihydrotentoxin
发明人：KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI
权利人:KUMIAI CHEMICAL INDUSTRY CO
摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.