CAS: 17763-67-6; Phenyl Trifluoromethanesulfonate

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CAS号358-23-6 三氟甲磺酸酐 | CAS号108-95-2 苯酚 | CAS号37595-74-7 N-苯基双(三氟甲磺酰亚胺) | CAS号109586-39-2 4-碘苯基三氟甲磺酸酯 | CAS号153688-92-7 2-iodophenyl tr... | CAS号66107-36-6 三氟甲烷磺酸2-氯苯酯 | CAS号78888-18-3 叔丁氧基 N-氨基甲酸丙烯 | CAS号335-05-7 三氟甲烷磺酰氟 | CAS号1529-17-5 三甲基苯氧基硅 | CAS号1493-13-6 三氟甲烷磺酸 | CAS号4096-21-3 1-苯基吡咯烷 | CAS号4096-20-2 N-苯基哌啶 | CAS号5424-19-1 3-苯酰基嘧啶 | CAS号4107-98-6 N,N-二异丙苯胺 | CAS号3074-43-9 1-甲基-4-苯基哌嗪 | CAS号451-40-1 二苯乙酮 | CAS号55-21-0 苯甲酰胺 | CAS号14584-33-9 4-Fluoro-alpha-... | CAS号771-98-2 1-苯基-1-环己烯

乙酸苯酯置于copper(L) Iodide,Sulfur,三乙胺,Sodium T-Butanolate体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 34.0H,反应生成苯基三氟甲烷磺酸酯
参考文献:以s8为硫源时,通过c-o键的裂解,形成铜催化的c-s键的形成
标题:以s8为硫源时,通过c-o键的裂解,形成铜催化的c-s键的形成
摘要:摘要 提出了一种有用且适用的通过c-o键活化一锅无味合成不对称和对称二芳基硫化物的方法.首先,报道了一种新的有效方法,用于合成不对称硫化物,该方法使用酚酯(如乙酸酯,甲苯磺酸酯和三氟甲磺酸酯)的交叉偶联反应,并以芳基硼酸或三苯基氯化锡为偶联伙伴.取决于反应,发现s 8 / Kf或s 8 / Nao T-Bu体系在铜盐存在下和在聚乙二醇中作为绿色溶剂是硫的有效来源.然后,以s 8为硫源和nao T由酚类化合物合成对称的二芳基硫醚描述了在n 2下在120oc的无水dmf中的-Bu .通过这些方案,与不直接将硫醇和芳基卤化物用于制备硫化物的现有方案相比,各种不对称和对称硫化物的合成变得更加容易. 提出了一种有用且适用的通过c-o键活化一锅无味合成不对称和对称二芳基硫化物的方法.首先,报道了一种新的有效方法,用于合成不对称硫化物,该方法使用酚酯(如乙酸酯,甲苯磺酸酯和三氟甲磺酸酯)的交叉偶联反应
Doi:10.1055/s-0036-1588508

专利信息

专利号:US-2015336866-A1
优先权日:2013-01-01
标题:Synthesis of difluoromethyl ethers and sulfides
发明人：HARTWIG JOHN; FIER PATRICK
权利人:UNIV CALIFORNIA
摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

专利号:US-10927135-B2
优先权日:2017-08-03
标 题:Metal-free direct arylation of dialkyl phosphonates for the synthesis of mixed alkyl aryl phosphonates
发明人：KANG JUN YONG; HUANG HAI
权利人:THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VE
摘要:Provided herein are phosphates, thiophosphates, phosphonates, and phosphinates, methods of making same, and methods of using these compounds and methods for the generation of pharmaceutically relevant phosphate, phosphonate, and phosphinate analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-12319712-B2
优先权日:2018-05-09
标 题:Methods of synthesizing a polynucleotide array using photoactivated agents
发明人：RAJASEKARAN JOHN J; JAYARAMAN VASANTH; VENUGOPAL ANIRUDH; BEI KANG; WANG TIANHAO; KRISHNA KARTHIK; KRISHNAMURTHY HARI KRISHNAN
权利人:VIBRANT HOLDINGS LLC
摘要:Described herein are methods for the synthesis of DNA polynucleotides and polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of DNA microarrays.

专利号:US-2023357286-A1
优先权日:2020-07-24
标 题:Ketone synthesis and applications
发明人：KISHI YOSHITO; UMEHARA ATSUSHI
权利人:HARVARD COLLEGE
摘要:Provided are new nickel./zirconium-mediated coupling reactions useful in the synthesis of ketone-containing compounds, e.g., halichondrin natural products and related molecules. A feature of the present disclosure is the use of a nickel(I) catalyst in tandem with a nickel (II) catalyst in the Ni/Zr-mediated coupling reactions. Without wishing to be bound by any particular theory, the nickel (I) catalyst selectively activates the electrophilic coupling partner (i.e., the compound of Formula (A)), and the nickel(ll) catalyst selectively activates the nucleophilic coupling partner (i.e., a thioester of Formula (B)). This dual catalyst system leads to improved coupling efficiency and eliminates the need for a large excess of one of the coupling partners (i.e., a compound of Formula (A) or (B)).

专利号:US-10266503-B1
优先权日:2016-05-24
标 题 :Sulfoxide ligand metal catalyzed oxidation of olefins
发明人：WHITE M CHRISTINA; AMMANN STEPHEN E; LIU WEI; MA RULIN
权利人:UNIV ILLINOIS
摘要:The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp 3 )-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.

专利号:US-5530125-A
优先权日:1992-02-25
标 题 :Synthesis of α-substituted-aryl ethylamines
发明人：BERGER JOEL G; CHANG WEI K; KOZLOWSKI JOSEPH A; ZHOU GUOWEI
权利人:SCHERING CORPORTION
摘要:PCT No. PCT/US93/01425 Sec. 371 Date Aug. 19, 1994 Sec. 102(e) Date Aug. 19, 1994 PCT Filed Feb. 23, 1993 PCT Pub. No. WO93/16997 PCT Pub. Date Sep. 2, 1993.A novel process for the preparation of alpha -substituted arylacetamides wherein the substituent is an aromatic group or a 1-alkenyl or 1-cycloalkenyl group and wherein the nitrogen atom carries no hydrogen atoms comprises the reaction of an arylacetamide having one or two hydrogen atoms on the alpha -carbon atom, wherein the nitrogen atom carries no hydrogen atoms, with a strong base in an inert aprotic organic solvent, followed by reaction with a zerovalent transition metal catalyst and then with a compound of the formula R4-X, wherein R4 is selected from aromatic groups, 1-alkenyl groups and 1-cycloalkenyl groups and X is a particular leaving group, especially a triflate group. The alpha -substituted arylacetamides are useful as intermediates in the preparation (by reduction) of alpha -substituted arylethylamines, e.g., 1-substituted-2,3,4,5-tetrahydro-1H-3-benzazepines, having pharmacological activity. Certain benzazepines wherein the 1-substituent R4 is 1-(1-cycloalkenyl) are novel.