CAS: 1820-80-0; 1H-Pyrazol-3-Amine

相似化合物

952674-76-9 1003011-02-6 863504-84-1

上下游产品

3-aminopyrazole-4-carboxylic acid trans-β-chloroacrylonitrile 3-nitro-1H-pyrazole cyanoacetaldehyde pyrimidin-7-one5-methyl-4H-pyrazolo1,5-apyrimidin-7-one pyrimidin-7-one5-(p-nitrophenyl)pyrazolo1,5-apyrimidin-7-one pyrimidin-7-one4,7-dihydropyrazolo1,5-apyrimidin-7-one pyrimidine7-Methylpyrazolo1,5-apyrimidine

Trans-3-Chlor-Acrylnitril置于一水合肼体系中,用 甲醇 用作溶剂,化学反应 4.0H,以60%的收率获得3-氨基吡唑
参考文献:Ege,Guenter; Franz,Hermann,Journal Of Heterocyclic Chemistry,1982,Vol. 19,P. 1267-1273
标题:Ege,Guenter; Franz,Hermann,Journal Of Heterocyclic Chemistry,1982,Vol. 19,P. 1267-1273

专利信息

专利号:US-2009221834-A1
优先权日:2006-04-20
标题 :Synthesis of 5-Beta-Keto-1,2,4-Oxadiazoles and Conversion of 5-Beta-Keto-1,2,4 Oxadiazoles to N-Pyrazolyl Amidoximes
发明人：JENSEN DAVID R; SIDENSTICK JOHN E
权利人:JENSEN DAVID R; SIDENSTICK JOHN E
摘要:The disclosed invention relates to a process for preparing 5-β-keto-1,2,4-oxadiazoles of formula (I), and conversion of 5-β-keto-1,2,4-oxadiazoles (I) into N-pyrazolyl amidoximes of the formula (II) through reaction with hydrazine. The process is defined by two steps. An amidoxime, which may be prepared in situ, is condensed with a β-keto ester to form a 5-β-keto-1,2,4-oxadiazole. The 5-β-keto-1,2,4-oxadiazole is subsequently reacted with hydrazine to furnish the desired N-pyrazolyl amidoxime. The disclosed invention provides several advantages over the current state of the art for the synthesis of N-pyrazolyl amidoximes, which require the condensation of a pyrzolylamine with an actived substrate and subsequent reaction with hydroxyl amine. N-pyrazolyl amidoximes are useful synthetic intermediates, especially for the preparation of photographic developing chemicals.

专利号:US-8076479-B2
优先权日:2006-08-28
标题 :Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates
发明人：CHEN FRANK XING; KEERTIKAR KARTIK M; KUO SHEN-CHUN; LEE HONG-CHANG; RAGHAVAN RAMANI R; WU GEORGE G; XIE JI
权利人:CHEN FRANK XING; KEERTIKAR KARTIK M; KUO SHEN-CHUN; LEE HONG-CHANG; RAGHAVAN RAMANI R; WU GEORGE G; XIE JI; SCHERING CORP
摘要:Disclosed is a process for the synthesis of compounds of Formula I n nby sequentially aminating, first with a primary amine and then with a secondary amine, an intermediate compound of the structure of Formula E1,n n nwherein R 1 is a linear, branched, or cyclic alkyloxy functional group of the structure (—R 2a —OH), R 2a is a linear, branched or cyclic alkyl group, R 2 is a linear, branched or cyclic alkyl group, and R 3 is an alkylene-heterocycle, said process comprising forming intermediate compound of Formula E1 by reacting, in a refluxing reaction solvent selected from alcohols having 5 or less carbon atoms and mixtures of two or more thereof, a methanol solution of a salt of a 4-alkyl-3-amino-pyrazole compound of Formula C1,n n nwith a diamidization reagent selected from dimethylmalonate, monomethylmalonyl-chloride, and malonyl dichloride in the presence of a Lewis base having sufficient proton affinity to abstract a proton from the 1-position nitrogen on the pyrazole ring.

专利号:US-8071782-B2
优先权日:2007-10-02
标 题 :Synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles
发明人：DENG XIAOHU; MANI NEELAKANDHA S
权利人:DENG XIAOHU; MANI NEELAKANDHA S; JANSSEN PHARMACEUTICA NV
摘要:This invention concerns the synthesis of highly substituted pyrazoles, which are structural components of pharmacological compounds, through reaction of hydrazones with nitroolefins.

专利号:US-5719283-A
优先权日:1990-06-20
标 题:Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents
发明人：BELL ANDREW SIMON; BROWN DAVID; TERRETT NICHOLAS KENNETH
权利人:PFIZER
摘要:Compounds of the formula ##STR1## wherein R 1 is H, C 1 -C 3 alkyl, C 3 -C 5 cycloalkyl or C 1 -C 3 perfluoroalkyl; n R 2 is H, C 1 -C 6 alkyl optionally substituted by OH, C 1 -C 3 alkoxy or C 3 -C 6 cycloalkyl, or C 1 -C 3 perfluoroalkyl; n R 3 is H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, C 3 -C 7 cycloalkyl, C 1 -C 6 perfluoroalkyl or (C 3 -C 6 cycloalkyl)C 1 -C 6 alkyl; n and Y is chloro, bromo, or fluoro. n The above compounds are intermediates useful in the synthesis of certain pyrazolopyrimidinones which inhibit cyclic guanosine 3', 5'-monophosphate phosphodiesterase.

专利号:EP-1105359-B1
优先权日:1998-08-21
标 题:Solid phase synthesis of compounds by carbon-carbon bond forming mitsunobu reactions
发明人：CHATURVEDI SURENDRAKUMAR
权利人:PE CORP NY
摘要:Processes are provided for the Mitsunobu alkylation reaction of carbon-carbon bond formation between a solid support reagent and a reagent in solution. The resulting novel products can be prepared as a combinatorial library by high-throughput, parallel synthesis under robotic automation. Cleaved or support-bound products are useful precursors to biologically active compounds.

专利号:US-5679800-A
优先权日:1984-08-30
标题 :2-Amino-3,5,disubstituted-4-halothiophenes and processes for the synthesis thereof
发明人：EGLI ROBERT; HENZI BEAT
权利人:CLARIANT FINANCE BVI LTD
摘要:Compounds of the formula wherein R, R1 and R2 are as defined in the specification and R3 is amino or -N=N-K, wherein K is a coupling component radical. The compounds wherein R3 is -N=N-K are useful as disperse dyes, and those wherein it is amino are useful as intermediates in the synthesis of those wherein it is -N=N-K.