合成目标产物 1-Methoxy-4-(Methylthio)Benzene 主要起始原料 Dimethyl Disulfide And 4-Iodoanisole
(文献来源)合成步骤主要原料 Dimethyl Disulfide 和 4-Iodoanisole
1,4-二氯苯 以 N,N-二甲基甲酰胺 用作溶剂,化学反应 41.0H,反应生成4-甲氧基茴香硫醚 参考文献:Simple Syntheses Of Aryl Alkyl Thioethers And Of Aromatic Thiols From Unactivated Aryl Halides And Efficient Methods For Selective Dealkylation Of Aryl Alkyl Ethers And Thioethers 标题:Simple Syntheses Of Aryl Alkyl Thioethers And Of Aromatic Thiols From Unactivated Aryl Halides And Efficient Methods For Selective Dealkylation Of Aryl Alkyl Ethers And Thioethers 摘要: Doi:10.1055/s-1983-30501
专利号:US-6207838-B1 优先权日:1999-04-30 标 题 :Electrochemically generated organothiating reagents and their use 发明人:GLASS RICHARD S; JOUIKOV VIATCHESLAV V 权利人:UNIV ARIZONA 摘要:Electrolysis of organic disulfides in liquid sulfur dioxide is used to obtain organothiating agents, which can then be reacted with appropriate substrates to effect the synthesis of organothioaromatic compounds efficiently and in high yields. With appropriate phenolic compounds, regioselective substitution occurs in which para substitution greatly exceeds ortho substitution.
专利号:US-4996314-A 优先权日:1986-03-11 标题 :6-(disubstituted amino)carbapenem compounds 发明人:YOSHIOKA TAKEO; CHIDA NORITAKA; WATANABE AZUMA; FUKAGAWA YASUO; ISHIKURA TOMOYUKI 权利人:SANRAKU INC 摘要:A compound represented by the formula ##STR1## wherein R 1 represents a lower alkyl group or a lower haloalkyl group; R 2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR 4 or --SO 2 R 5 in which R 4 represents an aralkyl group or a substituted or unsubstituted alkyl group and R 5 represents an alkyl group or a substituted or unsubstituted aryl group; and R 3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic. n The compounds of the formula ##STR2## wherein R 1 and R 2 are as defined above are important intermediates for the synthesis of the compounds of formula (I) and/or the aforesaid di-(substituted amino) carbapenem-series antibiotics.
专利号:US-5721255-A 优先权日:1992-08-19 标 题 :Substituted benzylamino nitrogen containing non-aromatic heterocycles 发明人:HOWARD HARRY R; NAKANE MASAMI; IKUNAKA MASAYA; SATAKE KUNIO; ROSEN TERRY J; LOWE III JOHN A; O'NEILL BRIAN T; ITO FUMITAKA 权利人:PFIZER 摘要:The present invention relates to novel substituted benzylamino nitrogen containing non-aromatic heterocycles and, specifically, to compounds of the formula ##STR1## wherein W, R 1 , R 2 , R 3 and A are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula I are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.
专利号:US-8367871-B2 优先权日:2007-03-09 标 题 :Process for production of optically active sulfoxide compound using iron-salan complex catalyst 发明人:KATSUKI TSUTOMU; EGAMI HIROMICHI 权利人:NISSAN CHEMICAL IND LTD; KATSUKI TSUTOMU; EGAMI HIROMICHI 摘要:An optically active sulfoxide compound that is useful as an intermediate for synthesis or an active ingredient of a physiologically active substance such as a pharmaceutical agent is produced at a high optical purity. A process for producing an optically active sulfoxide compound of formula (4) comprises oxidizing a sulfide compound of formula (3) in the presence of an optically active metal complex of formula (1), (1′), (2) or (2′) by using an oxidizing agent. The present invention is also directed to the optically active metal complex.
专利号:CN-116969875-A 优先权日:2023-07-21 标题:Synthesis method of thioester functionalized 2-oxoindole
专利号:CN-115557985-B 优先权日:2022-12-06 标 题 :A kind of method of C-S bond synthesis silane in selective cracking thioether
[参考文献]: U Pérez, Et Al. Transient-State Kinetics Of The Reactions Of 1-Methoxy-4-(Methylthio)Benzene With Horseradish Peroxidase Compounds I And Ii. Biochemistry. 1990 Mar 20;29(11):2757-63.
合成参考文献
摘要:Barsegyan, Y. A.; Vil’, V. A.; Tomkinson, N. C. O.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2022) 1, 266. 摘要:Lattanzi, A., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 1010. 摘要:Lattanzi, A., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 989. 摘要:Lattanzi, A., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 1000. 摘要:Lattanzi, A., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 1006.