CAS: 35037-73-1; 1-Isocyanato-4-(Trifluoromethoxy)Benzene

上下游产品

CAS号461-82-5 对三氟甲氧基苯胺 | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号32315-10-9 三光气 | CAS号187235-48-9 1-[(6S)-2-nitro... | CAS号212696-37-2 4-(三氟甲氧基)苯基氨基甲酸叔丁酯 | CAS号870552-95-7 1-(2-bromopheny...

P-Trifluoromethoxyphenylcarbamoyl Chloride置于盐酸体系中,用96%的收率获得产物4-三氟甲氧基苯基异氰酸酯
参考文献:一种对三氟甲氧基苯基异氰酸酯的制备方法及制备装置
标题:一种对三氟甲氧基苯基异氰酸酯的制备方法及制备装置
摘要:本发明公开了一种对三氟甲氧基苯基异氰酸酯的制备方法及制备装置,将对三氟甲氧基苯胺与溶剂配成溶液待用;在反应釜中加入固体光气和溶剂;80~130oc下,滴加对三氟甲氧基苯胺溶液,滴加时长为0.5~2H,回流保温0.5~2H;反应过程通过dcs控制系统监控;得反应混合液;采用连续化蒸馏方式提纯,产物收率达96%,产品含量>=99.5%.制备装置包括混配釜,反应釜,蒸馏塔,第一冷凝器,第二冷凝器,真空机组和产物储罐;蒸馏塔的顶部,中部,底部分别设有不同沸点的组分出口.本发明采用绿色工艺制备对三氟甲氧基苯基异氰酸酯,从物料的计量,输送及操作参数均采用dcs控制;采用一步法合成,反应稳定,副反应少;采用连续化蒸馏提纯,产品质量及收率高.

专利信息

专利号:US-2022281888-A1
优先权日:2019-09-25
标题:Bicyclic carboxylates as modulators of transporters and uses thereof
发明人：SANDANAYAKA VINCENT; GORECZNY GREGORY
权利人:NIROGY THERAPEUTICS INC
摘要:The present invention generally relates to the field of transporter modulators, e.g., monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

专利号:US-9879050-B2
优先权日:2013-08-30
标 题 :Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase
发明人：LEE RICHARD E; ZHAO YING; GRIFFITH ELIZABETH; ZHENG ZHONG; SINGH AMAN P
权利人:ST JUDE CHILDREN'S RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-9833457-B2
优先权日:2008-01-25
标题:Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
发明人：MJALLI ADNAN M M; GADDAM BAPU; POLISETTI DHARMA RAO; KOSTURA MATTHEW J; GUZEL MUSTAFA
权利人:VTV THERAPEUTICS LLC
摘要:The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to psoriatic arthritis.

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:US-10822377-B2
优先权日:2015-03-04
标 题:Substituted urea depsipeptide analogs as activators of the ClpP endopeptidase
发明人：LEE RICHARD E; ZHAO YING; JIUYU LIU
权利人:ST JUDE CHILDRENS RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.