CAS: 4165-60-0; Nitrobenzene-D (Isotopic)

上下游产品

CAS号1076-43-3 氘代苯 | CAS号4165-60-0 氘代硝基苯-d{5} | CAS号98-95-3 硝基苯 | CAS号4165-60-0 氘代硝基苯-d{5} | CAS号98-95-3 硝基苯 | CAS号4165-61-1 苯胺-2,3,4,5,6-d5 | CAS号30504-49-5 偶氮苯-d10 | CAS号198-55-0 苝 | CAS号14545-23-4 苯胺-d7 | CAS号125687-18-5 苯基-d5-肼盐酸盐 | CAS号15826-91-2 乙酰苯胺-D5 | CAS号1235219-21-2 Sulfanilic Acid-d4

氘代苯置于硫酸,硝酸体系中,化学反应 4.33H,以96.4%的收率获得产物硝基苯-D5
参考文献:一类新型的带有三个配体中心自由基的镧系元素配合物:配体场能分裂和磁耦合的NMR评估
标题:一类新型的带有三个配体中心自由基的镧系元素配合物:配体场能分裂和磁耦合的NMR评估
摘要:三个自由基阴离子ph-Bian配体(ph-Bian =双-(苯基亚氨基)-Ac烯醌)与镧系元素离子的结合会产生一系列ln(ph-Bian)3型均配六配位络合物.磁耦合数据通过顺磁性溶液NMR光谱法测量.将1 H NMR与2 H结合部分氘代化合物的1 H NMR可以对大温度范围内的磁化率各向异性进行详细研究.通过与y类似物(金属处的反磁性)进行比较,观测到的化学位移被分为以配体和金属为中心的贡献.然后可以将具有顺磁性离子的配合物的金属中心贡献分为假接触位移和费米接触位移.后者在ph-Bian支架内很大,这表明镧系元素离子和自由基配体之间的磁耦合非常重要.伪接触位移进一步与x射线衍射实验获得的结构数据相关.通过拟合所观测到的磁化率各向异性的温度依赖性来确定配体场参数.通过这种方法确定的电子结构表明,Er和tm类似物是单分子磁体(smm)的候选物.这些结果证明了将NMR光谱应用于一般顺磁性系统以及特别是单分子磁体的研究的可能性.
DOI:10.1002/chem.201901388

专利信息

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:CN-102424656-A
优先权日:2011-09-22
标 题:A kind of stable isotope labeled Sudan I and its synthesis method

专利号:CN-104003901-A
优先权日:2014-06-12
标 题:A kind of stable isotope labeled Citrus Red No. 2 and its synthesis method