Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于ammonium Hydroxide体系中,化学反应生成 4-氨基邻苯二甲酸 参考文献:Bogert; Renshaw,Journal Of The American Chemical Society,1908,Vol. 30,P. 1143 标题:Bogert; Renshaw,Journal Of The American Chemical Society,1908,Vol. 30,P. 1143
专利号:US-4348536-A 优先权日:1975-05-28 标 题 :Odorless catalysts for the synthesis of polyurethanes 发明人:BLAHAK JOHANNES; HUEBNER HANS; KOSTER JOHANNES; MEINERS HANS J; THOMAS HEINZ 权利人:BAYER AG 摘要:The instant invention is directed to novel compounds and the use thereof in producing polyurethane resins. The compounds generally correspond to the following formula: wherein n is an integer of from 1 to 5, R is a C1-C5 alkyl group Y is a C1-C5 alkyl group or a and Z is a where n=0 or 1, X is -O- or and R' is an aliphatic group having from 1 to 15 carbon atoms and may contain ester, ether, or amide groups or tertiary nitrogen and, when m=0, R' may be a hydrogen atom.
专利号:US-2007060499-A1 优先权日:2005-09-15 标 题 :Chloroquine combination drugs and methods for their synthesis 发明人:KOSAK KENNETH M 权利人:KOSAK KENNETH M 摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.
专利号:US-2007166281-A1 优先权日:2004-08-21 标题 :Chloroquine coupled antibodies and other proteins with methods for their synthesis 发明人:KOSAK KENNETH M 权利人:KOSAK KENNETH M 摘要:This invention discloses compositions of chloroquine-coupled active agents such as therapeutic antibodies or insulin, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the drug is delivered, thereby reducing the overall dosage needed. The compositions comprise a chloroquine substance coupled to a drug directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing the drug for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and antibody or insulin to their site of action.
专利号:US-5663449-A 优先权日:1989-05-19 标 题 :Intermediate compounds in the synthesis of heteroarylpiperidines, pyrrolidines and piperazines
专利号:US-2022143183-A1 优先权日:2019-02-23 标题:Photoswitchable protacs and synthesis and uses thereof 发明人:TRAUNER DIRK; REYNDERS MARTIN; MATSUURA BRYAN; BEROUTI MARLEEN; PAGANO MICHELE 权利人:UNIV NEW YORK 摘要:Provided are compounds, which may be referred to as PHOTACs (photoswitchable proteolysis targeting chimeras), and compositions, kits, and methods of making and using PHOTACs. PHOTACs have one or more E3 ligase ligand(s), one or more photoswitchable group(s), optionally, one or more linker(s), and one or more ligand(s) for a target protein. PHOTACs may be suitable for use in methods to treat diseases, such as, for example, cancer. PHOTACs may also be suitable for use in methods to induce selective degradation of a target protein.
专利号:CN-114057838-A 优先权日:2022-01-11 标 题 :Solid Phase Synthesis of Acetyl Hexapeptide-8
[参考文献]: F Lloyd Jr, Et Al. The Production Of A Bispecific Anti-Cea, Anti-Hapten (4-Amino-Phthalate) Hybrid-Hybridoma. J Natl Med Assoc. 1991 Oct;83(10):901-4.
合成参考文献
参考文献:10.1007/s13369-025-10053-9 摘要:Alenazi NA. Breaking the 11% Efficiency Barrier in Dye-Sensitized Solar Cells: Synergistic Co-Sensitization with CZ-1, TP-2, and Black Dye. Arab J Sci Eng. 2025 Mar 08;51(2):1435–46. doi: 10.1007/s13369-025-10053-9.