CAS: 5468-37-1; 2-Aminoacetophenone Hydrochloride

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CAS号70-11-1 2-溴苯乙酮 | CAS号614-21-1 苯甲酰硝基甲烷 | CAS号1816-88-2 2-azido-1-pheny... | CAS号1386376-70-0 (R)-N-tert-buta... | CAS号1386376-82-4 (R)-N-tert-buta... | CAS号108783-73-9 4-(5-phenyl-1,3... | CAS号111396-49-7 4-(5-phenyl-1,3... | CAS号109355-73-9 ethyl N-(2-hydr... | CAS号142991-72-8 (5-METHYL-3-TRI... | CAS号4190-14-1 N-苯乙酮苯甲酰胺 | CAS号1721-93-3 1-甲基异喹啉 | CAS号92-71-7 2,5-二苯基噁唑 | CAS号1794-31-6 2-naphthalen-2-... | CAS号22397-40-6 Oxazole,2-(2-ch... | CAS号18860-06-5 2-cyclohexyl-5-...

Alpha-氯乙酰苯置于盐酸体系中,用 乙醇,二氯甲烷 作为反应溶剂,化学反应 73.0H,反应生成 2-氨基苯乙酮盐酸盐
参考文献:结合水的固体闪烁体:合成,发射特性和3H和14C计数测试.
标题:结合水的固体闪烁体:合成,发射特性和3H和14C计数测试.
摘要:研究了2.5-二苯基恶唑(ppo)(通过从相应的硫脲中脱除h2S制备)的碳二亚胺衍生物,制备中的某些中间体以及其他几种ppo衍生物的光谱和时间分辨荧光性质以及相对荧光量子产率在溶液中和固态下测试其作为固态闪烁体的适用性.碳二亚胺在酸性条件下与水缓慢反应,反应生成脲.在3H和14C计数中,将这些系统与其他ppo衍生物与硫酸钠作为干燥剂的固体混合物进行了比较,将其作为化学结合水的固体闪烁体.化学和吸收性水结合闪烁体都证明能够计算3H和14C衰减,
DOI:10.1002/1521-3765(20000804)6:15<2809::Aid-Chem2809>3.0.Co;2-M

专利信息

专利号:US-4879389-A
优先权日:1986-06-25
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO
权利人:ACHIWA KAZUO
摘要:New chiral phosphinopyrrolidine compounds of the general formula: (I) or (I') wherein R1 is a hydrogen atom, -COR, -COOR, -CONHR or -SO2-R where R is an alkyl or aryl group, R2 and R3 each represents independently an aryl group which may have a substituent or substituents, and R4 and R5 each represents independently an aliphatic or cycloaliphatic hydrocarbyl group which may have a substituent or substituents, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:US-11040939-B1
优先权日:2020-06-23
标 题 :N-transfer reagent and method for preparing the same and its application
发明人：CHOU HO-HSUAN; LU GUAN-HAN; HSUEH HSIAO-CHIN; HUANG TZU-CHIA
权利人:UNIV NAT CHENG KUNG
摘要:Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): n n n n n n n n n n The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

专利号:US-12234240-B2
优先权日:2018-08-09
标 题:Substituted imidazo[5,1-d][1,2,3,5]tetrazines for the treatment of cancer
发明人：HERGENROTHER PAUL J; FAN TIMOTHY M; SVEC RILEY L
权利人:UNIV ILLINOIS
摘要:New synthetic methods to provide access to previously unexplored functionality at the C8 position of substituted imidazo[5,1-d][1,2,3,5]tetrazines of Formula I. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM.

专利号:US-5580751-A
优先权日:1990-09-14
标题:Process for the preparation of C-terminally amidated peptides
发明人：BUCHARDT OLE; BREDDAM KLAUS; HENRIKSEN DENNIS
权利人:CARLSBERG AS
摘要:A process for preparing C-terminally amidated peptides, Peptide-NH2, is presented. In a first step, a substrate component is reacted with a nucleophile component in the presence of trypsin or a carboxypeptidase using as nucleophile a compound NH2-R to form a first reaction product Peptide-NH-R. In a second step, the first reaction product is non-enzymatically chemically cleaved to form the C-terminally amidated product, Peptide-NH2. The substrate component is selected from a) peptide derivatives Peptide-X-Y, where X is an amino acid or peptide residue and Y is OH, OMe or C-terminal modification and c) C-terminally esterified peptides, Peptide-OR', where R' is alkyl, aryl, heteroaryl, or aralkyl. The nucleophile component is selected from wherein A-F and A'-E' are carbon atoms or up to two hetero atoms, Y is H, alkyl, aryl, aralkyl, oxo or carboxy, X1-X5 are H or various substituents. The cleavage may be induced by photolysis, solvolysis, reduction, rearrangement elimination, or oxidation. The process may be adapted to enzymatic synthesis and lends itself to C-terminal amidation of many types of peptides.

专利号:US-12304912-B2
优先权日:2020-07-28
标 题 :Fused bicyclic RAF inhibitors and methods for use thereof
发明人：BELFIELD ANDREW; JONES CLIFFORD DAVID; MARGATHE JEAN-FRANÇOIS; COLLETTO CHIARA
权利人:JAZZ PHARMACEUTICALS IRELAND LTD
摘要:The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

专利号:US-7629488-B2
优先权日:2005-03-14
标 题 :Process for the preparation of opioid modulators
发明人：CAI CHAOZHONG; HE WEI
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.