CAS: 5471-51-2; 4-(4-Hydroxyphenyl)-2-Butanone

上下游产品

4-(4-methoxyphenyl)-2-butanone methyl vinyl ketone phenol 1-Hydroxy-3-butanone1-(4-hydroxy-phenyl)-butane-2,3-dione-2-oxime raspberry ketone tetra-O-acetyl-β-D-glucopyranoside 1-(p-hydroxybenzyl)-3,6-diazahomoadamantan-9-one 4-(4-Hydroxyphenyl)-2-methyl-2-butanol

4-(对羟基苯基)-2-丁醇置于nicotinamide Adenine Dinucleotide Phosphate,Secondary Alcohol Dehydrogenase W110G Mutant From Thermoanaerobacter Pseudoethanolicus,丙酮体系中,用 Aq. Buffer 作为反应溶剂,化学反应 24.0H,反应生成 覆盆子酮
参考文献:使用两个突变体假乙醇嗜热厌氧菌脱氢酶的两个突变体对乙醇进行脱硝和立体转化
标题:使用两个突变体假乙醇嗜热厌氧菌脱氢酶的两个突变体对乙醇进行脱硝和立体转化
摘要:据报道,一种针对醇的一锅两步除臭方法是使用两个嗜热厌氧假单胞菌仲醇脱氢酶突变体,它们表现出不同程度的立体选择性.该方法还用于(R)醇的立体转化(即类似mitsunobu的反应).
DOI:10.1002/ejoc.202000728

专利信息

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-6133018-A
优先权日:1997-06-02
标 题 :Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE L; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:EP-1075534-B8
优先权日:1998-03-11
标 题 :Improvements in the enzymatic synthesis of chiral amines
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:US-11124809-B2
优先权日:2017-12-21
标题 :Production of alpha-(R)-(E)-(+)-ionone in recombinant Saccharomyces cerevisiae
发明人：AGOSIN TRUMPER EDUARDO ESTEBAN; SAITUA PEREZ FRANCISCO JAVIER; LOPEZ SALINAS JAVIERA CECILIA; DOMARADZKI MACIEJ E; IBACETA ACEVEDO MAXIMILIANO; ARENAS FRIGOLETT NATALIA
权利人:CENTROME INC
摘要:This invention provides improved biological synthesis of the apocarotenoid α-ionone in Saccharomyces cerevisiae. The final native step involved in the natural apocarotenoid pathway depends on an endogenous farnesyl pyrophosphate synthase (FPPs). From there, heterologous geranylgeranyl pyrophosphate synthase (crtE), phytoene synthase (crtB), phytoene desaturase (crtI), lycopene ε-cyclase (LycE) and a Carotenoid Cleavage Dioxygenase (CCD1) are required to complete the synthesis of α-ionone. Lycopene ε-cyclase from lettuce (Lactuca sativa) or modified cyclase from Arabidopsis thaliana was used to overproduce lycopene which was then cleaved by the carotenoid cleavage dioxygenase from Petunia hybrida (Ph-CCD1).

专利号:US-11746364-B2
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains
发明人：PLUSKAL TOMÃ?S; Weng jing-ke
权利人:WHITEHEAD INST BIOMEDICAL RES
摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

专利号:US-7737287-B2
优先权日:2002-03-28
标 题 :Anomeric derivatives of monosaccharides
发明人：MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI
权利人:ALCHEMIA LTD
摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.