专利号:US-5220016-A 优先权日:1991-07-29 标 题:Synthesis of navelbine analogs 发明人:MAGNUS PHILIP D; THURSTON LEE S 权利人:UNIV TEXAS 摘要:The invention is a de novo synthesis of the norcatharanthine moiety of navelbine. The synthesis includes condensing a Grignard reagent prepared from an amine-protected R(+)-piperidinyl methanol with an N-protected 2-methoxyoxalyl indole. The indole N-protecting group is removed to provide a 2-methoxyindole hydroxy ester which is coupled to vindoline. After removal of the amineprotecting group from the piperidinyl group, ring closure to the indole moiety provides dihydrodesethyl navelbine. Other derivatives and analogs of navelbine with potential clinical applications in cancer chemotherapy may be readily synthesized. The synthesis opens a route to a wide variety of navelbine modifications, including modifications at or near the tryptamine bridge.
专利号:WO-2025134143-A1 优先权日:2023-12-19 标题 :A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof 发明人:MALVIYA NITIN JAIKANT; SINGH VIPENDER; MAL SANJIB; YADAV SANTOSH; SHAH JIGARKUMAR HARKISHANDAS; KAVITAKE SANTOSH GIRIDHAR; BORHADE AJIT SAHEBRAO; KLAUSENER ALEXANDER G M 权利人:PI INDUSTRIES LTD 摘要:The present invention discloses a method for the synthesis of compounds of formula (I) or a salt thereof, wherein R is selected from hydrogen, halogen, cyano, C1-C12 alkyl, C1-C12 haloalkyl, C1-C12 alkoxy, C1-C12 haloalkoxy, or C3-C8 cycloalkyl; R4 is selected from hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, C1-C12 haloalkyl, C2- C12 haloalkenyl, C2-C12 haloalkynyl, C1-C12 alkoxy, C1-C12 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 cycloalkyl-C1-C10 alkyl; and n represents an integer selected from 0-4. The process further comprises the synthesis of an anthranilic diamide compound of formula (A).
专利号:WO-2018154596-A1 优先权日:2017-02-22 标 题 :Process for synthesis of tiotropium bromide monohydrate 发明人:REDDY G NITHUN; REDDY G SAMHITHA; REDDY G MADAALASA; RAMANI M; REDDY G PRATAP 权利人:GBR LABORATORIES PVT LTD; RACHANA PHARMA TECH 摘要:Provided herein is a process for synthesis of tiotropium bromide wherein the coupling of scopine with 2, 2-dithienyl glycolate is achieved by a two step process under mild conditions.
专利号:US-4468523-A 优先权日:1982-06-16 标题 :Synthesis of dialkyl oxalates by the heterogeneously catalyzed oxidative carbonylation of alcohols 发明人:LEONARD JOHN J; SOFRANKO JOHN A 权利人:ATLANTIC RICHFIELD CO 摘要:Synthesis of dialkyl oxalates by the oxidative carbonylation of liquid monohydric saturated alcohols of from 1 to 20 carbon atoms with carbon monoxide and oxygen or an oxygen-containing gas in the presence of a catalytic amount of a catalyst comprising palladium or a salt thereof in combination with vanadium in the oxide (V 2 O 5 , V 2 O 4 , V 2 O 3 ) form and titanium or a non-hydrolyzable salt thereof, said catalyst being present in a heterogeneous phase.
专利号:US-4451666-A 优先权日:1982-08-06 标题:Synthesis of oxalate esters by the oxidative carbonylation of alcohols with a heterogeneous manganese promoted Pd-V-P catalyst 发明人:SOFRANKO JOHN A; GAFFNEY ANNE M 权利人:ATLANTIC RICHFIELD CO 摘要:Synthesis of dialkyl oxalates by the heterogeneous catalyzed oxidative carbonylation of liquid monohydric saturated alcohols of from 1 to 20 carbon atoms with carbon monoxide and oxygen or an oxygen-containing gas in the presence of a catalytic amount of a catalyst comprising palladium or a salt thereof in combination with a crystalline vanadium-phosphorus-manganese containing compound.
专利号:US-7384739-B2 优先权日:2001-11-14 标题 :Compositions for enhancing DNA synthesis, DNA polymerase-related factors and utilization thereof 发明人:KITABAYASHI MASAO; KUROITA TOSHIHIRO; ISHIDA YOSHIKAZU; KOMATSUBARA HIDEYUKI; NISHIYA YOSHIAKI; OKA MASANORI; KAWAMURA YOSHIHISA; IMANAKA TADAYUKI 权利人:TOYO BOSEKI 摘要:The invention provides methods, kits, and compositions for enhancing synthesis of DNA involving a carboxylate ion-supplying substance that is effective in promoting DNA synthesis in enzymatic DNA synthesis reactions. The invention further provides a thermostable DNA polymerase-related factor derived from Thermococcus species, which has an activity to promote the DNA synthesis activity of DNA polymerase or which binds to DNA polymerase.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 176. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 87. 摘要:Sainsbury, M., Science of Synthesis Knowledge Updates, (2010) 1, 225. 摘要:Shi, Y.; Cole-Hamilton, D. J.; Kamer, P. C. J., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 2, 188. 摘要:Besson, M.; Pinel, C., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 2, 263.