CAS: 796073-69-3; (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Chloro-14-Hydroxy-85,14-Dimethoxy-33,2,7,10-Tetramethyl-12,6-Dioxo-7-Aza-1(6,4)-Oxazinana-3(2,3)-Oxirana-8(1,3)-Benzenacyclotetradecaphane-10,12-Dien-4-Yl N-(4-Mercapto-4-Methylpentanoyl)-N-Methyl-L-Alaninate

上下游产品

2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]maytansineN2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]maytansine 4-mercapto-4-methylvaleronitrile N-methyl-N-[4-methyl-(4-methyldithio)-1-oxopropyl]-L-alanine N-methyl-N-[4-methyl-(4-methyldithio)-1-oxopentyl]-L-alanine2'-deacetyl-N2'-(4-methyl-4-methythio-1-oxopentyl)maytansineN2'-deacetyl-N2'-(4-methyl-4-methythio-1-oxopentyl)maytansine

专利信息

专利号:US-2025127768-A1
优先权日:2022-06-30
标 题:Therapeutic targeting of inositol pyrophosphate synthesis in cancer
发明人：GOLUB TODD; BONDESON DANIEL
权利人:BROAD INST INC
摘要:The subject matter disclosed herein is generally directed to treating cancers sensitive to phosphate dysregulation with inhibitors of inositol pyrophosphate (PP-InsP) synthesis, in particular, inhibitors of inositol hexakisphosphate kinases IP6Ks.

专利号:WO-2023179723-A1
优先权日:2022-03-25
标题:Cleavable fragment directed by affinity fragment, design and synthesis thereof, and use thereof in preparation of site-directed drug conjugate
发明人：HUANG WEI; TANG FENG; ZENG YUE
权利人:SHANGHAI INST MATERIA MEDICA CAS
摘要:Provided in the present invention are a cleavable fragment directed by an affinity fragment, the design and the synthesis thereof, and the use thereof in the preparation of a site-directed drug conjugate. Specifically, provided in the present invention is a conjugate with a ligand affinity directing group. The conjugate is as represented by formula I: AT-CL-R (I), wherein AT is an affinity moiety for a target protein (TP); CL is a cleavable fragment which has a self-cleaving reactivity; and R is a group to be modified to the target protein.

专利号:CN-116836235-A
优先权日:2022-03-25
标 题 :Affinity fragment-directed cleavable fragments, their design, synthesis and application in the preparation of site-directed drug conjugates

专利号:EP-4501945-A1
优先权日:2022-03-25
标 题:Cleavable fragment directed by affinity fragment, design and synthesis thereof, and use thereof in preparation of site-directed drug conjugate

专利号:WO-2024006972-A1
优先权日:2022-06-30
标 题 :Therapeutic targeting of inositol pyrophosphate synthesis in cancer