专利号:US-4130712-A 优先权日:1976-07-12 标 题 :Synthesis of biotin 发明人:VASILEVSKIS JANIS 权利人:HOFFMANN LA ROCHE 摘要:A procedure for the synthesis of biotin is disclosed whereby unsaturated diacylated biotin precursors are catalytically hydrogenated with the substantial absence of sulfur poisoning. The hydrogenation procedure dislcosed herein results in optically pure biotin.
专利号:WO-2009148195-A1 优先权日:2008-06-02 标题:5-(4-hydroxybenzyl)thiazolidine-2,4-dione as intermediate for synthesis of thiazolidinedione based compounds and process for preparing the same 发明人:PARK JIN OH; KIM YONG GIL; SON HAN IL; LEE YUN JEONG; KIM EUN MI 权利人:DAEBONG LS LTD; PARK JIN OH; KIM YONG GIL; SON HAN IL; LEE YUN JEONG; KIM EUN MI 摘要:The present invention relates to 5-(4-hydroxybenzyl)thiazolidine-2,4-dione represented by the following Chemical Formula [1], which is useful as an intermediate for synthesis of thiazolidinedione based compounds, a method for preparing the compound, and a method for preparing pioglitazone or pioglitazone hydrochloride, which is a thiazolidinedione based drug and useful in treating and preventing diabetes, using the 5-(4-hydroxybenzyl)thiazolidine-2,4-dione represented by Chemical Formula [1] as an intermediate:
专利号:WO-9420521-A1 优先权日:1993-03-12 标 题:Process for synthesizing and selecting sequences of covalently bound components 发明人:SCHNEIDER-MERGENER JENS 权利人:SCHERING AG; SCHNEIDER MERGENER JENS 摘要:A process is disclosed for the solid phase or liquid phase synthesis of selectable sequences of aminoacids of monosaccharides, the coupling sites being predetermined on a substrate. The sequences consist of determined aminoacids or monosaccharides and of undetermined aminoacids or monosaccharides at a defined position in the sequence. According to the process the synthesis of the sequence is carried out in a continuous way and comprises, the following steps: (aa) adding the determined aminoacid or the determined monosaccharide at a defined site on the substrate, and (bb) adding to the substrate a mixture of undetermined aminoacids or monosaccharides equimolar with regard to the coupling sites.
专利号:US-9333491-B2 优先权日:2012-03-07 标题:Catalyst for oxygenate synthesis, oxygenate production apparatus, and method of producing oxygenate 发明人:IWANE KAZUYOSHI; RICHARDS RYAN; CADIGAN Christopher 权利人:SEKISUI CHEMICAL CO LTD; COLORADO SCHOOL OF MINES 摘要:This invention relates to a catalyst for oxygenate synthesis to use for synthesizing an oxygenate from mixed gas containing hydrogen and carbon monoxide, the catalyst comprising, an (A) component: rhodium, a (B) component: manganese, a (C) component: an alkali metal, and a (Z) component: magnesium oxide.
专利号:US-9272971-B2 优先权日:2012-02-28 标题 :Catalyst for C2 oxygenate synthesis, device for manufacturing C2 oxygenate, and method for manufacturing C2 oxygenate 发明人:NISHINO TOMOAKI; MIYAMA TOSHIHITO; MURATA KAZUHISA; LIU YANYONG 权利人:SEKISUI CHEMICAL CO LTD; NAT INST OF ADVANCED IND SCIEN 摘要:The present invention relates to a catalyst for C2 oxygenate synthesis in which a hydrogenated active metal is supported on a porous carrier to synthesize a C2 oxygenate from a mixed gas containing hydrogen and carbon monoxide, wherein the porous carrier has an average pore diameter of 0.1 to 20 nm.
专利号:US-11897827-B1 优先权日:2022-11-22 标 题 :Carbon isotope exchange mediated by vanadium complexes 发明人:BUKHRYAKOV KONSTANTIN 权利人:BUKHRYAKOV KONSTANTIN; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES 摘要:The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, carbon isotope exchange (CIE) on target bioactive molecules. Methods that allow CIE directly on drug candidates are of great importance to chemistry, biology, and medicine. Especially valuable are catalytic procedures that rely on a limited collection of available labeled materials. The instant method comprises converting a methyl group to terminal â•?CH2 utilizing transfer dehydrogenation catalysts to enable V-based olefin metathesis, followed by a hydrogenation step. The one-pot strategy allows the formal methylation/demethylation sequence and can be applied to an assortment of alkyl-containing compounds.
1: Jellesen MS, Olsen CB, Ruff S, Spiewak R, Hamann D, Hamann CR, White IR, Johansen JD, Thyssen JP. Electrochemical Screening Spot Test Method for Detection of Nickel and Cobalt Ion Release From Metal Surfaces. Dermatitis. 2018 Jun 21. doi: 10.1097/DER.0000000000000389. [Epub ahead of print] pii: 13030/qt88q6q97w. doi: 10.2116/analsci.34.387. doi: 10.1007/s00128-018-2297-5. Epub 2018 Feb 19. doi: 10.1016/j.jelechem.2017.10.026. Epub 2017 Oct 12. 8: Bogan R, Maas HJ, Zimmermann T. Chemical stability of reactive skin decontamination lotion (RSDL(®)). Toxicol Lett. 2018 Sep 1;293:264-268. doi: 10.1016/j.toxlet.2017.09.016. Epub 2017 Sep 28. doi: 10.1155/2017/9476065. Epub 2017 Jul 19. 10: Rousset E, Ciofini I, Marvaud V, Hanan GS. Facile One-Pot Synthesis of Ruthenium(II) Quaterpyridine-Based Photosensitizers for Photocatalyzed Hydrogen Production. Inorg Chem. 2017 Aug 21;56(16):9515-9524. doi: 10.1021/acs.inorgchem.7b00771. Epub 2017 Aug 3. pii: E1711. doi: 10.3390/s17081711.
合成参考文献
参考文献:10.1111/j.1600-0536.2011.01919.x 摘要:Biesterbos J, Lidén C, van der Valk P. Nickel on the Dutch market: 10 years after entry into force of the EU Nickel Directive. Contact Dermatitis. 2011 Aug;65(2):115–7. doi: 10.1111/j.1600-0536.2011.01919.x.