CAS: 122350-52-1; Fmoc-Glu-Obzl

相似化合物

13030-09-6 30924-93-7 34404-30-3

上下游产品

CAS号154672-63-6 Fm°C-­Glu(t-Bu)-OBn | CAS号71989-18-9 Fm°C-O-叔丁基-L-谷氨酸 | CAS号100-39-0 溴化苄 | CAS号100-51-6 苯甲醇

Benzyl Ester Of α-N-(9-Fluorenylmethoxycarbonyl)-γ-Tert-Butyl Ester Of L-Glutamic Acid置于三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 3.5H,以91%的收率获得fmoc-L-谷氨酸-α-苄酯
参考文献:A New Synthesis Of N.Alpha.,N.Delta.-Protected N.Delta.-Hydroxycycloornithine And Its Homolog From An L-Glutamic Acid Derivative
标题:A New Synthesis Of N.Alpha.,N.Delta.-Protected N.Delta.-Hydroxycycloornithine And Its Homolog From An L-Glutamic Acid Derivative
摘要:
Doi:10.1021/jo00083A041

专利信息

专利号:US-2004063918-A1
优先权日:2002-07-16
标 题:Methods and materials for the synthesis of modified peptides

专利号:US-8618049-B2
优先权日:2009-09-08
标题:Ester insulin
发明人：KENT STEPHEN B H; SOMA YOUHEI
权利人:KENT STEPHEN B H; SOMA YOUHEI
摘要:Compositions and methods related to ester insulin or derivatives thereof are provided. The compositions include Glu A4 -Thr B30 ester insulin, in which side chains of Glu A4 and Thr B30 of native human insulin or an insulin analogue such as insulin lispro are covalently linked via a single ester bond. The ester insulin is efficiently folded, forming the desired disulfides. The Thr B30 -Glu A4 ester bond can be cleaved in vitro or in vivo to give the desired folded insulin with full biological activity. The ester insulin is readily prepared by total chemical synthesis, and amendable to cost-effective, large scale manufacturing. Also provided are pharmaceutical compositions and kits for use in practicing the subject methods. Also provided are methods of using the subject compositions and kits in the treatment of a variety of different disease conditions, particularly glucose metabolic disorders such as diabetes and obesity.