CAS: 153034-86-7; 2-Chloro-4-Iodopyridine

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98027-84-0 69045-79-0 2402-78-0

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2-氯吡啶置于2,2,6,6-四甲基哌啶,正丁基锂,二氯(N,N,N',N'-四甲基乙二胺)锌(II),碘,二异丙胺体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 6.0H,以51%的收率获得2-氯-4-碘吡啶
参考文献:乙撑二氧噻吩-吡啶低聚物交替的合成,光学和理论研究:从平面共轭到螺旋结构向手性构型的演变
标题:乙撑二氧噻吩-吡啶低聚物交替的合成,光学和理论研究:从平面共轭到螺旋结构向手性构型的演变
摘要:合成了一系列交替增加溶解度的交替3,4-亚乙基二氧噻吩-炔基吡啶低聚物(da)n,并研究了它们的光物理性质和非线性光学性质.它们的二次极化率是通过超瑞利散射实验确定的,以获得有关它们在溶液中的构象的信息.这些发色团基于富电子(d)和缺电子(a)部分的交替,显示出光学性质,该性质是由(da)n同源序列中n = 1-4的偶极和螺旋特征的组合产生的.从偶极共轭平面结构(n = 1,2)到螺旋结构(n= 3,4)由对称敏感的二阶非线性光学实验的结果清楚地证明了这一点.这暗示了一种用于二阶非线性光学的高效手性生色团的方法.有趣的是,这种结构演变对光物理性质也有重大影响:吸收和荧光发射均显示偶极平面导数(n = 1-2)中随着重复单元数量的增加而出现红移和增色变化,但在螺旋结构中显示出饱和效应(n = 2-4).此外,对于没有给电子或吸电子取代基的化合物,螺旋结构在700-750 Nm(40-100 Gm)处显示出相当大的双光子吸收.
Doi:10.1002/cphc.201601057

专利信息

专利号:WO-2015131100-A1
优先权日:2014-02-28
标题:Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:The use of ligands to tune the reactivity and selectivity of transition metal-catalysts for C(-sp3)-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)-H arylation using pyridine and quinoline derivatives: the former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-p-Ar ' -cc-amino acids with excellent levels of diastereoselectivity (d.r. > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)-H olefination of a protected alanine.

专利号:US-8178559-B2
优先权日:2004-12-30
标 题:Organic compounds
发明人：BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

专利号:CN-114014790-A
优先权日:2021-12-03
标 题 :Synthesis method of selenide/thioether compound and synthesized compound