CAS: 173154-00-2; (S)-4-Benzyl-3-((2S,4R)-4-Bromo-2-Isopropyl-4-((2S,4S)-4-Isopropyl-5-Oxotetrahydrofuran-2-yl)-Butanoyl)Oxazolidin-2-One

上下游产品

(S)-4-Benzyl-2-oxazolidinone isopentanoyl chloride (S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one (S)-3-((2S,4S)-4-azido-2-isopropyl-4-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)butanoyl)-4-benzyloxazolidin-2-one (3S,5S)-tert-butyl-3-isopropyl-5-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-2-oxopyrrolidine-1-carboxylate (3S,5S)-3-isopropyl-5-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)pyrrolidin-2-one (S)-4-Benzyl-2-oxazolidinone

(S)-4-苄基-2-唑烷酮置于正丁基锂,Magnesium(II) Perchlorate,间氯过氧苯甲酸,Lithium Bromide,Lithium Hexamethyldisilazane体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 15.0H,反应生成(S)-3-((2S,4R)-4-溴-4-((2S,4S)-四氢-4-异丙基-5-羰基呋喃-2-基)-2-异丙基丁酮基)-4-苄基恶唑烷酮-2-酮
参考文献:A Facile,Six-Step Process For The Synthesis Of (3S,5S)-3-Isopropyl-5-((2S,4S)-4-Isopropyl-5-Oxo-Tetrahydrofuran-2-yl)-2-Oxopyrrolidine-1-Carboxylic Acid Tert-Butyl Ester,The Key Synthetic Intermediate Of Aliskiren
标题:A Facile,Six-Step Process For The Synthesis Of (3S,5S)-3-Isopropyl-5-((2S,4S)-4-Isopropyl-5-Oxo-Tetrahydrofuran-2-yl)-2-Oxopyrrolidine-1-Carboxylic Acid Tert-Butyl Ester,The Key Synthetic Intermediate Of Aliskiren
摘要:A Facile,Six-Step Process For The Synthesis Of (3S,5S)-3-Isopropyl-5-((2S,4S)-4-Isopropyl-5-Oxotetrahydro-Furan-2-yl)-2-Oxopyrrolidine-1-Carboxylic Acid Tert-Butyl Ester From (S)-4-Benzyloxazolidin-2-One 2 In An Overall 50% Yield Is Reported. The Key Transformations Include: A Highly Efficient Diastereoselective Epoxidation,Lewis Acid-Catalyzed Ring-Opening With Bromide,An S(N)2 Reaction Using Nan3,And A Tandem Reduction-Cyclization Reaction.
Doi:10.1021/acs.Oprd.5B00009