CAS: 19814-75-6; 9,9-Dimethyl-9H-Xanthene

上下游产品

xanth-9-one trimethylaluminum 2-(2-bromophenyl)propanol phenol 2,7-bis(1,1-dimethylpropyl)-9,9-dimethylxanthene 2,7-bis(1,1-dimethylethyl)-9,9-dimethylxanthene 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene 9,9-dimethyl-9H-xanthene-4,5-dicarbaldehyde

2-(2-Phenoxyphenyl)Propan-2-Ol置于三氟化硼乙醚体系中,用 二氯甲烷 用作溶剂,化学反应 0.5H,以90 Mg的收率获得9,9-二甲基氧杂蒽
参考文献:铜催化的自由和空间受阻的保护基2-溴苄基叔醇与酚和苯胺的偶联:黄嘌呤和二氢ac啶的简便合成†
标题:铜催化的自由和空间受阻的保护基2-溴苄基叔醇与酚和苯胺的偶联:黄嘌呤和二氢ac啶的简便合成†
摘要:一种用于呫吨和含在一个9季碳原子dihydroacridines的合成简单和有效的方法个位上,被呈现.重要的是,在铜催化下,该方案促进了空间位阻和保护基的2-溴苄基叔醇在与苯酚和苯胺的交叉偶联反应中的平稳参与.介导的分子内的c-C键形成的路易斯酸启用一个季碳原子的形成在9个位上.值得注意的是,此两步操作方案需要单柱纯化技术.
Doi:10.1039/c6Ra03447K

专利信息

专利号:US-2024309003-A1
优先权日:2021-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-2022274930-A1
优先权日:2019-06-14
标题:Processes and compounds for the decarboxylative amination of redox-active esters with diazirines
发明人：LOPCHUK JUSTIN M; CHANDRACHUD PREETI P
权利人:H LEE MOFFITT CANCER CT & RES
摘要:The invention described herein relates generally to processes for the synthesis of amine-containing organic compounds. More specifically, described herein relates to processes for the decarboxylative amination of redox-active esters with diazirines and the products formed thereof. Compounds for use in the above processes are also described.

专利号:US-8716507-B2
优先权日:2008-10-31
标题 :Iron(II) catalysts containing diimino-diphosphine tetradentate ligands and their synthesis
发明人：MIKHAILINE ALEXANDRE; FREUTEL FRIEDERIKE; SUI-SENG CHRISTINE; MEYER NILS; MORRIS ROBERT H; LAGADITIS PARASKEVI OLYMPIA
权利人:MIKHAILINE ALEXANDRE; FREUTEL FRIEDERIKE; SUI-SENG CHRISTINE; MEYER NILS; MORRIS ROBERT H; LAGADITIS PARASKEVI OLYMPIA; GOVERNING COUNCIL OF UNIVERSITY OF TORONTO
摘要:New hexa-coordinate iron (II) complexes comprising compounds of formula (I) are described. These compounds comprise a tetradentate ligand with donor atoms comprising nitrogen and phosphorus. These complexes are shown for the first time to be useful catalysts for the hydrogenation of ketones, aldehydes, or imines to produce alcohols or amines, and the asymmetric hydrogenation of prochiral ketones or imines to produce non-racemic alcohols or amines. The source of the hydrogen can be hydrogen gas or a hydrogen-donating molecule such as isopropanol or hydrogen-donating mixture such as formic acid and an amine depending on the structure of the catalyst. In certain embodiments, the axial ligands on the catalyst comprise organonitrile ligands, carbonyl ligands, isonitrile ligands, or combinations thereof. The catalysts and the preparation thereof are disclosed. A reaction using phosphine and diamine precursors that is templated by the iron ion is the preferred route to the catalysts.

专利号:US-2025304580-A1
优先权日:2021-11-09
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-10919921-B2
优先权日:2016-05-06
标题:P-chiral phosphine ligands and use thereof for asymmetric synthesis
发明人：BOERNER ARMIN; HOLZ JENS; RUMPEL KATHARINA
权利人:BASF SE
摘要:The present invention relates to chiral compounds with two optically active phosphorus atoms, chiral transition metal catalysts which comprise these compounds as ligands, a process for preparing the P-chiral compounds and processes for asymmetric synthesis using the chiral transition metal catalysts. The present invention specifically relates to a process for preparing an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of an optically active transition metal catalyst according to the invention. Yet more specifically, the present invention relates to a process for the asymmetric hydrogenation of citral, and also a process for preparing optically active menthol.

专利号:WO-2020118597-A1
优先权日:2018-12-13
标 题 :Process for making 1- [ (3r, 4s) -4-cyanotetrahydropyran-3-yl] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino] pyrazole-4-carboxamide
发明人：CHASSAING CHRISTOPHE PIERRE ALAIN; YIN JINGJUN; CLEATOR EDWARD; SONG LICHEN; XIAO WENSONG; DAHMEN THOMAS; SALANTA DANIEL; SCHEIPERS CLAUDIA; SCHMITT HARALD
权利人:INTERVET INT BV; INTERVET INC; CHASSAING CHRISTOPHE PIERRE ALAIN; YIN JINGJUN; CLEATOR EDWARD; SONG LICHEN; XIAO WENSONG; DAHMEN THOMAS; SALANTA DANIEL; SCHEIPERS CLAUDIA; SCHMITT HARALD
摘要:New processes for the preparation of 1- [ (3R, 4S) -4-cyanotetrahydropyran-3-yl] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino] pyrazole-4-carboxamide (I) which include (i) novel more efficient synthesis for bromo and iodo pyridine intermediates, (ii) synthesis of a novel pyrazole ester intermediate which can be obtained in enantiopure form and (iii) the combination of these intermediates into compound (I).