CAS: 20826-03-3; 5-Methoxynicotinic Acid

相似化合物

113118-83-5 298204-74-7 98491-82-8

上下游产品

CAS号29681-46-7 5-甲氧基-3-吡啶羧酸甲酯 | CAS号30766-22-4 5-羟基烟酸甲酯 | CAS号298204-74-7 5-甲氧基烟腈

5-羟基烟酸甲酯置于n-((R)-2-Hydroxy-2-((S)-1,2,3,4-Tetrahydroisoquinolin-3-yl)Ethyl)-4-(1,2-Oxazinane-2-Carbonyl)Benzamide,Sodium Hydride体系中,用 四氢呋喃,甲醇,正己烷,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 17.83H,反应生成5-甲氧基烟酸
参考文献: Tetrahydroisoquinoline Derived Prmt5-Inhibitors[fr] Inhibiteurs De Prmt5 Dérivés De Tétrahydroisoquinoléine
标题: Tetrahydroisoquinoline Derived Prmt5-Inhibitors[fr] Inhibiteurs De Prmt5 Dérivés De Tétrahydroisoquinoléine
摘要:式i的化合物,其中:N为1或2;P为0或1;R1可选地为一个或多个卤素或甲基基团;R2A和r2B分别选自以下组:(I) F;(II) H;(III) Me;和(Iv) Ch2Oh;R2C和r2D分别选自以下组:(I) F;(II) H;(III) Me;和(Iv) Ch2Oh;R3A和r3B分别选自h和me;R4为h或me;R5为h或me;R6A和r6B分别选自h和me;A为(I)可选地取代的苯基;(II)可选地取代的萘基;或(III)可选地取代的c5-12杂环基.

专利信息

专利号:US-10316018-B2
优先权日:2015-08-27
标题 :Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators
发明人：LEE KATHERINE LIN; ALLAIS CHRISTOPHE PHILIPPE; DEHNHARDT CHRISTOPH MARTIN; GAVRIN LORI KRIM; HAN SEUNGIL; HEPWORTH DAVID; LEE ARTHUR; LOVERING FRANK ELDRIDGE; MATHIAS JOHN PAUL; OWEN DAFYDD RHYS; PAPAIOANNOU NIKOLAOS; SAIAH EDDINE; STROHBACH JOSEPH WALTER; TRZUPEK JOHN DAVID; WRIGHT STEPHEN WAYNE; ZAPF CHRISTOPH WOLFGANG
权利人:PFIZER
摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.