CAS: 324-74-3; 4-Fluoro-1,1-Biphenyl

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CAS号108-86-1 溴苯 | CAS号1765-93-1 4-氟苯硼酸 | CAS号591-50-4 碘苯 | CAS号371-14-2 4-氟苯肼 | CAS号71-43-2 苯 | CAS号460-00-4 对氟溴苯 | CAS号98-80-6 苯硼酸 | CAS号108-90-7 氯苯 | CAS号352-34-1 4-氟碘苯 | CAS号17763-78-9 三氟甲磺酸4-联苯基酯 | CAS号398-21-0 4-溴-4′-氟联苯 | CAS号146328-84-9 2-氟-5-苯基苯甲酸 | CAS号92-94-4 对三联苯 | CAS号10540-31-5 4-(4-氟苯基)苯腈 | CAS号116748-66-4 4'-氟[1,1'-二苯基]-4-磺酰氯 | CAS号5731-10-2 4-氟苯基-4-苯甲酸 | CAS号13041-66-2 1-methoxy-4-(4-... | CAS号169963-54-6 4-(4-phenylphen... | CAS号28952-41-2 1-methyl-4-(4-p... | CAS号720-74-1 1-(4'-FLUORO-BI...

对羟基联苯置于硫酰氟,四甲基氟化铵体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 24.0H,以85%的收率获得产物4-氟联苯
参考文献:通过芳基氟磺酸酯中间体对苯酚进行亲核脱氧氟化
标题:通过芳基氟磺酸酯中间体对苯酚进行亲核脱氧氟化
摘要:本报告描述了一种通过芳基氟磺酸 (Arofs) 中间体使用硫酰氟 (So2F2) 和四甲基氟化铵 (Nme4F) 对苯酚进行脱氧氟化的方法.我们首先证明 Arofs 与 Nme4F 的反应在温和条件下(通常在室温下)进行,以提供广泛的电子多样化和富含官能团的芳基氟化物产品.然后将该转化转化为使用 So2F2 和 Nme4F 的组合将苯酚一锅法转化为芳基氟化物.从头算计算表明,碳-氟键的形成是通过协调的过渡态而不是离散的迈森海默中间体进行的.
DOI:10.1021/jacs.6B12911

专利信息

专利号:US-4808607-A
优先权日:1985-05-22
标题 :Imidazole analogs of mevalonolactone and derivatives thereof for use in inhibiting cholesterol biosynthesis and lowering blood cholesterol level
发明人：WAREING JAMES R
权利人:SANDOZ PHARMACEUTICALS CORP
摘要:Compounds of the formula and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow and the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

专利号:WO-2024258613-A9
优先权日:2023-06-16
标题:Tetrachlorovancomycin and derivatives
发明人：BOGER DALE
权利人:SCRIPPS RESEARCH INST
摘要:A total synthesis of a new class of vancomycin analogues of reduced synthetic complexity was developed. The synthesis, achieved by the addition of two aryl chloride substituents to provide tetrachlorovancomcyin aglycon (Compound II), tetrachlorovancomcyin (Compound I ), and their derivatives, permitted a streamlined total synthesis of the new class of glycopeptide antibiotics by removing atropisomer stereochemical control and enabled the simultaneous and further activated SNAr macrocyclizations that establish the tricyclic skeleton of Compound I. In addition to the antimicrobial evaluation of tetrachlorovancomycin (Compound I), the preparation of key binding pocket and peripherally-modi fied derivatives, which overcome vancomycin resistance and introduce independent and synergistic mechanisms of action, revealed their exceptional antimicrobial potency and provide the foundation for use of this new class of synthetic glycopeptide analogues. Also disclosed are a pharmaceutical composition containing bactericidal amount of tetrachlorovancomycin, a derivative thereof or a salt of either dissolved or dispersed in a pharmaceutically acceptable diluent.

专利号:US-4755606-A
优先权日:1985-05-22
标 题 :Imidazolyl-3,5-di-(diphenyl-butylsilyloxy) carboxylic acid ester intermediates
发明人：WAREING JAMES R
权利人:SANDOZ PHARMACEUTICALS CORP
摘要:Compounds of the formula and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined herein below, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

专利号:WO-2023167325-A1
优先权日:2022-03-03
标 题 :Immobilized palladium catalyst and method for producing same, and application of this catalyst to coupling reaction
发明人：YAMADA YOICHI; ZHANG ZHENZHONG; OHNO AYA
权利人:RIKEN
摘要:The present invention addresses the problem of developing a metal catalyst which is suitable for continuous flow organic synthesis reaction, is excellent in durability, and has high activity.　The present invention provides an immobilized palladium catalyst comprising a complex composed of palladium and a copolymer formed from (A) a repeating unit that has a certain substituted aromatic hydrocarbon ring and (B) a repeating unit that has a certain nitrogen-containing aromatic hetero ring.

专利号:US-7527754-B2
优先权日:2005-12-21
标 题 :Photochromic indeno-fused naphthopyrans
发明人：CHOPRA ANU
权利人:TRANSITIONS OPTICAL INC
摘要:Photochromic materials comprising indeno-fused naphthopyrans having substituents comprising a 4-fluorophenyl group and a 4-aminophenyl group bonded to the 3-position of the indeno-fused naphthopyran are disclosed. The photochromic materials may exhibit faster fade rates as compared to similar indeno-fused naphthopyrans without a 4-fluorophenyl group and a 4-aminophenyl group bonded to the 3-position of the indeno-fused naphthopyran. Substituted 2-propyn-1-ols utilized for the synthesis of the indeno-fused naphthopyrans disclosed herein are disclosed. Photochromic compositions and articles, such as optical elements, incorporating the photochromic materials disclosed herein are also disclosed.

专利号:CN-113652705-B
优先权日:2021-06-23
标题:A kind of method for N-hydroxyphthalimide catalyzed electrolytic synthesis of fluorenone