CAS: 613-84-3; 2-Hydroxy-5-Methylbenzaldehyde

上下游产品

formaldehyd p-cresol chloral hydrate hydrogen cyanide 2-hydroxy-5-methyl-benzaldehyde-[2]pyridylimine 4-methyl-1,2-dihydroxybenzene 6-methyl-3-phenylcoumarin 3-chloromethyl-5-methylsalicylaldehyde

对甲酚置于sodium Hydroxide体系中,用 氯仿,水 作为反应溶剂,化学反应 4.0H,以46%的收率获得产物5-甲基水杨醛
参考文献:一种新的配体h 4 Lox及其铁(iii)络合物作为开发异三金属络合物的平台
标题:一种新的配体h 4 Lox及其铁(iii)络合物作为开发异三金属络合物的平台
摘要:摘要不同性质的多种金属离子在单一配位化合物中的结合可提供一组独特的特性,适用于酶系统活性位点的模仿,新型分子磁性材料的开发和光致水分解催化剂的应用. .尽管如此,以受控方式制备杂多金属配合物是一项艰巨的任务.在这项工作中,我们提出了一种新的配体h4Lox,它被设计为合成异三金属配合物的平台.由h4Lox及其前体h2L合成了两个单核铁(iii)配合物[fe(l)] No3.meoh.2H2O(1)[fe(h2Lox)] No3.xh2O(2).2的结构揭示了由两个酚盐氧原子和两个肟氮原子组成的n2O2空位配位点.dft计算和esi-Ms数据表明,络合物2可以在稳定的异三金属络合物中容纳另外两个金属离子.通过uv-Vis光谱,循环伏安法和dft计算评估了酚酸酯基团的邻位取代基(cho和cnoh)在1和2的电子态中的作用.在计算的亲电指数ω与实验半波电位1,2及其类似物[fe(bbpen-Me)]
DOI:10.1016/j.Poly.2016.06.022

专利信息

专利号:US-7026339-B2
优先权日:2003-11-07
标题 :Inhibitors of HCV NS5B polymerase
发明人：YANG FAN; ZHANG BO; WICNIENSKI NANCY ANNE; PFEFFERKORN JEFFREY ALLEN; GREENE MEREDITH L; CHEN KE; NUGENT RICHARD A; REDING MATTHEW TODD; KELLY ROBERT CHARLES; MITCHELL MARK A; FUNK LEE A; HEIER III RICHARD FREDERICK; ANDERSON REBECCA MERRY
权利人:YANG FAN; ZHANG BO; WICNIENSKI NANCY ANNE; PFEFFERKORN JEFFREY ALLEN; GREENE MEREDITH L; CHEN KE; NUGENT RICHARD A; REDING MATTHEW TODD; KELLY ROBERT CHARLES; MITCHELL MARK A; FUNK LEE A; HEIER III RICHARD FREDERICK; ANDERSON REBECCA MERRY
摘要:The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment or prevention of HCV infection. The present invention also provides processes and intermediates for the synthesis of these compounds.

专利号:US-2003100119-A1
优先权日:1994-10-18
标题:Combinatorial synthesis and screening of supported organometallic compounds and catalysts
发明人：WEINBERG W HENRY; MCFARLAND ERIC; GOLDWASSER ISY; BOUSSIE THOMAS; TURNER HOWARD; BEEK JOHANNES A M VAN; MURPHY VINCE; POWERS TIM
权利人:SYMYX TECHNOLOGIES INC
摘要:The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

专利号:US-6756195-B2
优先权日:1996-07-23
标题 :Polymerization method from the combinatorial synthesis and analysis of organometallic compounds and catalysts
发明人：WEINBERG W HENRY; MCFARLAND ERIC; GOLDWASSER ISY; BOUSSIE THOMAS; TURNER HOWARD; BEEK JOHANNES A M VAN; MURPHY VINCE; POWERS TIMOTHY
权利人:SYMYX TECHNOLOGIES INC
摘要:The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

专利号:US-6440745-B1
优先权日:1994-10-18
标 题 :Combinatorial synthesis and screening of organometallic compounds and catalysts
发明人：WEINBERG W HENRY; MCFARLAND ERIC W; GOLDWASSER ISY; BOUSSIE THOMAS; TURNER HOWARD; BEEK JOHANNES A M VAN; MURPHY VINCE; POWERS TIM
权利人:SYMYX TECHNOLOGIES INC
摘要:The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

专利号:US-2005085555-A1
优先权日:1997-08-21
标 题:Composition, synthesis and therapeutic applications of polyamines
发明人：MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
摘要:This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicty of neutoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

专利号:US-2014057877-A1
优先权日:2002-12-18
标题:Therapeutic polyamine compositions and their synthesis
发明人：MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
权利人:MURPHY MICHAEL A; MALACHOWSKI MITCHELL R
摘要:This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicity of neurotoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be utilized to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.