CAS: 6313-33-3; Formimidamide Hydrochloride

该化合物是含有分子式CH5N2-HCl的白色晶状固体,通常在有机合成中,特别是在生产药品,农用化学品和染料时,用作多种用途的中间体;该化合物因其成份对称功能组具有高度的再活性,能够进行高效的凝聚和循环反应;其盐化形式会增加极地溶剂中的溶解性,便于在水体和酒精系统中处理;在标准储存条件下,盐酸形式因其稳定性及其在综合循环环化化合物中的作用而受到重视;建议对其进行适当处理,因为其潜在的刺激性.

结构式图片

相似化合物

146958-06-7 879643-71-7 879643-71-7

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

1,3,5-Triazine trichloroacetamidine hydr°Chloride acetonitrile ethanol1,3,5-Triazine 4-Methylpyrimidine Formimino-DL-alanin N-formimidoyl-L-leucineN-formimidoyl-L-leucine

合成工艺路线路线简述

    硫脲置于氯化铵体系中,化学反应生成 甲脒盐酸盐
    参考文献:Tabor; Rabinowitz,Biochemical Preparations,1957,Vol. 5,P. 100,103
    标题:Tabor; Rabinowitz,Biochemical Preparations,1957,Vol. 5,P. 100,103

    专利信息


    专利号:US-2025171686-A1
    优先权日:2023-11-27
    标题 :Room temperature ambient synthesis of metal-doped halide perovskite nanocrystals
    发明人:FELDMANN SASCHA; WUTTIG MATEO CARDENES; VANORMAN ZACHARY
    权利人:ECOLE POLYTECHNIQUE FED LAUSANNE EPFL; PRESIDENT AND FELLOWS OF HARVARD COLLEGE CAMBRIDGE MA
    摘要:A method of preparing a composition including crystalline particles of a halide perovskite, a composition and a perovskite-based device including the same. The halide perovskite has a chemical formula ABX3, wherein A is a monocation, B is selected from a combination of lead (II) and a dopant and X is selected from a halide.

    专利号:US-8252927-B2
    优先权日:2008-07-22
    标题:Synthesis of substituted 4-amino-pyrimidines
    发明人:KARGE REINHARD; LETINOIS ULLA; SHIEFER GERHARD
    权利人:KARGE REINHARD; LETINOIS ULLA; SHIEFER GERHARD; DSM IP ASSETS BV
    摘要:The present invention is directed to a process for the manufacture of compounds of formula IV wherein R 1 is an amino protecting group, and R 2 is hydrogen or C 1-10 alkyl, comprising a) reacting a compound of formula Ia, wherein M + is a cation, preferably selected from the group consisting of Li + , Na+, K + , ½ Mg 2+ and ½ Zn 2+ , (formula 1 a ) with an ammonium salt NH 4 + X − , wherein X − is an anion, preferably selected from the group consisting of chloride, bromide, sulfate and acetate, in a solvent to a compound of formula II b) reacting a compound of formula II with a nitrile R 2 —CN in the presence of a base to a compound of formula IV. The present invention is further directed to compounds of formula II and their use for the manufacture of vitamin B 1 .

    专利号:US-8198443-B2
    优先权日:2007-01-19
    标题 :Synthesis of 4-amino-pyrimidines scaffolds
    发明人:BONRATH WERNER; HAERTER RALPH; KARGE REINHARD; LETINOIS ULLA
    权利人:BONRATH WERNER; HAERTER RALPH; KARGE REINHARD; LETINOIS ULLA; DSM IP ASSETS BV
    摘要:Process for the manufacture of a compound of the structure (I) with R1=hydrogen, alkyl (C1-C10, linear, cyclic or branched, aliphatic or aromatic), NR′R″ (wherein R′ and R″ are independently selected from H, alkyl [C1-C10, linear, cyclic or branched, aliphatic or aromatic] and R2=CH2R3 wherein R3 is selected from NHR1′″ (with R′″=C(O)H, C(O)CH3, C(O)alkyl, CH2C6H2(OMe)3 or other saponifiable residues), alkyl (C1-C10, linear, cyclic or branched) aromatic residues, heteroaryl residues, substituted aryl residues, e.g. 3,4,5-trimethoxy-phenyl) wherein 1 equivalent of an α-formyl-propionitrile salt is reacted with 0.75 to 2 equivalents of an acetamidine salt in the presence of a Lewis acid.

    专利号:EP-1163230-B1
    优先权日:1999-03-08
    标题 :Formamidine sulfate and phosphate salts, their production and their use in the synthesis of 1,3,5-triazine
    发明人:GUETHNER THOMAS; KRAMMER DORIS; GRAML BERND
    权利人:DEGUSSA
    摘要:The invention relates to the use of formamidine salts of the general formula (I): (NH2-CH=NH2)nHx-nY, where Y is SO4, x is 2 and n is between 0.1 and 2.0, or Y is PO4, x is 3 and n is between 0.1 and 3.0. The salts obtained in accordance with the invention are especially easy to prepare from the technical perspective and make it possibly to produce high yields of highly pure 1,3,5-triazine by thermal decomposition of the corresponding formamidine salts.

    专利号:US-12415828-B2
    优先权日:2014-08-22
    标题:Modified oligonucleotides and methods for their synthesis
    发明人:STETSENKO DMITRY; KUPRYUSHKIN MAXIM; PYSHNYI DMITRII
    权利人:NOOGEN LLC
    摘要:Modified oligonucleotides that contain one or more of the phosphate groups substituted at phosphorus and methods for their synthesis are disclosed.

    专利号:US-2009069334-A1
    优先权日:2007-08-18
    标题:Pyridazine based alpha-helix mimetics
    发明人:REBEK JR JULIUS; BIROS SHANNON; MOISAN LIONEL; VOLONTERIO ALESSANDRO; MANN ENRIQUE; DALE TREVOR
    权利人:SCRIPPS RESEARCH INST
    摘要:The synthesis of new α-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available building block, 6. These scaffolds may be thought of as synthetic counterparts of amphiphilic α-helices having a “wet faceâ€? along one side and a hydrophobic face along the other side of the helix.
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: David D Díaz, Et Al. Modular Synthesis Of Formamidines And Their Formation Of Stable Organogels. Chem Commun (Camb). 2004 Nov 7:(21):2514-6.
    [参考文献]: Jia Huang, Et Al. Pharmacological Characterization Of A Bombyx Mori Alpha-Adrenergic-Like Octopamine Receptor Stably Expressed In A Mammalian Cell Line. Arch Insect Biochem Physiol. 2010 Feb;73(2):74-86.
    [参考文献]: José M Casas, Et Al. Synthesis And In Solution And Solid State Structural Study Of Intramolecular Pt...H Interactions In Pentafluorophenyl Platinum(Ii) Complexes Containing The Ligands Triazene, Formamidine, And 2-Aminopyridine. Inorg Chem. 2005 Dec 12;44(25):9444-52.
    [参考文献]: Lukasz Walewski, Et Al. Thermal Fluctuations And Infrared Spectra Of The Formamide-Formamidine Complex. J Phys Chem A. 2012 Oct 25;116(42):10412-9.
    [参考文献]: M A I Ahmed, Et Al. Synergistic Actions Of Formamidine Insecticides On The Activity Of Pyrethroids And Neonicotinoids Against Aedes Aegypti (Diptera: Culicidae). J Med Entomol. 2012 Nov;49(6):1405-10.

    合成参考文献


    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 176.
    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 144.
    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 201.
    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 261.
    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 133.
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