专利号:US-6084108-A 优先权日:1997-10-14 标 题 :Synthesis of 3-carbomethoxy-4,5-dimethylthiophene 发明人:FEVIG THOMAS L; LAU PATRICK H; PHILLIPS WENDELL G 权利人:MONSANTO CO 摘要:Fungicides having thiophene rings may be made from the intermediate compound 3-carbomethoxy-4,5-dimethylthiophene. That compound, and related compounds, may be produced by reacting an alpha mercaptoketone, e.g., 3-mercapto-2-butanone, with an acrylate, e.g., methyl-3-methoxy acrylate, in the presence of an alkoxide base, e.g., NaOMe, to form the substituted tetrahydrothiophene, followed by conversion to the aromatic thiophene with an acid treatment. The substituted tetrahydrothiophene is a novel compound.
专利号:US-7329767-B2 优先权日:2003-10-03 标 题:Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof 发明人:DEWIS MARK L; JOHN THUMPLASSERIL V; ECKERT MARKUS A; COLSTEE JAN HERMAN; DA COSTA NEIL C; PEI TAO 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formulan n nwherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
专利号:US-8007841-B2 优先权日:2003-10-03 标 题 :Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof 发明人:JOHN THUMPLASSERIL V; ECKERT MARKUS A; DEWIS MARK L; COLSTEE JAN HERMAN; DA COSTA NEIL C 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formula —(CH 2 ) n —, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
专利号:US-7141686-B2 优先权日:2003-07-10 标题:E2, E4, Z8-undecatrienoic acid and ester and carboxamide derivatives thereof, organoleptic uses thereof and processes for preparing same 发明人:DEWIS MARK L; HUBER MICHELLE E 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Described is a genus of E2,E4,Z8-undecatrienoic acid derivatives defined according to the structure: wherein Z represents -OR'' or -NRR' with the provisos that when Z is -OR'', R'' is hydrogen, C1-C6 straight chain or branched-chain alkyl or C3-C6 straight chain or branched-chain alkenyl; and when Z is -NRR', R represents, in the alternative, hydrogen, methyl or ethyl and R' represents methyl, ethyl, n-propyl, cyclopropyl, isopropyl, n-butyl, sec-butyl, isobutyl, 2-methylbutyl, cyclobutyl, cyclopentyl or allyl. The E2,E4,Z8-undecatrienoic acid derivatives are useful in imparting, augmenting and/or enhancing flavors, aromas and somatosensory effects in or to consumable materials such as foods, beverages, skin care products, oral care products, medicinal products and the like. Also described is a synthesis process for producing such derivatives.
参考标题:Domino Reaction For The Construction Of New 2-Oxo[1,2,4]Triazolo[5,1-C][1,4]Thiazines 作者:Fabio Mantellini,Francisco Palacios,Orazio Attanasi,Samuele Lillini,Jesús De Los Santos,Roberto Ignacio 摘要:The Synthesis Of Highly Functionalized α-Thiohydrazones By Michael Addition Of 3-Mercapto-2-Ketones To 1,2-Diazabuta-1,3-Dienes Is Described. The Phosphorylated α-Thiohydrazones Were Hydrolyzed Into β-Ketophosphine Oxides Or Phosphonates Containing A Mercapto Ketone In The A Position, While The α-Thiohydrazones With A Carboxylate Group Were Subsequently Transformed Into 2-Oxo-2,3,8,8A-Tetrahydro-1H-[1
合成参考文献
摘要:The Good Scents Company Information System 摘要:Ulrich, H., Science of Synthesis, (2004) 17, 121.