CAS: 700-37-8; 4-Chloro-2-Fluoro-1-Nitrobenzene

上下游产品

2,4-dichloronitrobenzene 3,4-dinitro-chlorobenzene 3-chlorofluorobenzene 5-chloro-2-nitro-N-propylaniline (5-Chloro-2-nitro-phenyl)-(3-methyl-butyl)-amine (1-Benzyl-pyrrolidin-3-yl)-(5-chloro-2-nitro-phenyl)-amine N-cyclohexyl-2-nitro-5-chloro-aniline

3-氯氟苯置于硫酸,Potassium Nitrate体系中,化学反应生成 4-氯-2-氟硝基苯
参考文献:Synthesis,Structure-activity Relationships,And In Vivo Efficacy Of The Novel Potent And Selective Anaplastic Lymphoma Kinase (Alk) Inhibitor 5-Chloro-N2-(2-Isopropoxy-5-Methyl-4-(Piperidin-4-yl)Phenyl)-N4-(2-(Isopropylsulfonyl)Phenyl)Pyrimidine-2,4-Diamine (Ldk378) Currently In Phase 1 And Phase 2 Clinical Trials
标题:Synthesis,Structure-activity Relationships,And In Vivo Efficacy Of The Novel Potent And Selective Anaplastic Lymphoma Kinase (Alk) Inhibitor 5-Chloro-N2-(2-Isopropoxy-5-Methyl-4-(Piperidin-4-yl)Phenyl)-N4-(2-(Isopropylsulfonyl)Phenyl)Pyrimidine-2,4-Diamine (Ldk378) Currently In Phase 1 And Phase 2 Clinical Trials
摘要:The Synthesis,Preclinical Profile,And In Vivo Efficacy In Rat Xenograft Models Of The Novel And Selective Anaplastic Lymphoma Kinase Inhibitor 15B (Ldk378) Are Described. In This Initial Report,Preliminary Structure-Activity Relationships (Sars) Are Described As Well As The Rational Design Strategy Employed To Overcome The Development Deficiencies Of The First Generation Alk Inhibitor 4 (Tae684). Compound 15B Is Currently In Phase 1 And Phase 2 Clinical Trials With Substantial Antitumor Activity Being Observed In Alk-Positive Cancer Patients.
DOI:10.1021/jm400402Q

专利信息

专利号:US-5354439-A
优先权日:1990-07-16
标 题 :Process for the synthesis of fluorinated derivatives
发明人：FORAT GERARD; GILBERT LAURENT; LANGLOIS BERNARD
权利人:RHONE POULENC CHIMIE
摘要:A process for the synthesis of fluorinated organic compounds and a reagent suitable for use in the process. The process is carried out by exchange with fluorides, while preferably agitating the reaction medium with ultrasonic sound.

专利号:US-7217842-B2
优先权日:2001-04-12
标题:Catalysts for nucleophilic substitution, synthesis thereof, composition containing them and use thereof
发明人：SCHANEN VINCENT; CRISTAU HENRI-JEAN; TAILLEFER MARC
权利人:RHONE POULENC CHIMIE
摘要:The invention concerns novel catalysts for aromatic nucleophilic substitution. Said catalysts are compounds of the general formula (I), wherein: R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , identical or different, are selected among hydrocarbon radicals; the Pn's, advantageously the same, are selected among metalloid elements of column V of a period higher than nitrogen; Z is a metalloid element of column V, advantageously distinct from Pn; preferably a nitrogen (N, P, As, Sb). The invention is applicable to organic synthesis

专利号:FR-2664589-A1
优先权日:1990-07-16
标题 :PROCESS AND REAGENT FOR THE SYNTHESIS OF ARYLIC FLUORINE DERIVATIVES.

专利号:JP-H04244049-A
优先权日:1990-07-16
标 题 :Method for the synthesis of fluorinated derivatives

专利号:RU-2193554-C2
优先权日:1996-12-24
标题 :DERIVATIVES OF AROMATIC AMINES ELICITING EFFECT INHIBITING OAC, METHOD OF THEIR SYNTHESIS AND INHIBITOR OF нOAC

专利号:CN-120247709-A
优先权日:2025-05-27
标题 :Synthesis method of 2, 4-difluoronitrobenzene and 2-fluoro-5-chloronitrobenzene