15484-46-5 = 80657-57-4 反应条件:1.1 Catalysts: Hydrogen Bromide,Ruthenium,[(1,2,5,6-η)-1,5-Cyclooctadiene]Bis[(1,2,3-η)-2-Methyl-2-Propenyl]-,1,1′-[(5R)-2,2′,3,3′-Tetrahydro[5,5′-Bi-1,4-Benzodioxin]-6,6′-Diyl]Bis[1,1-Diphe... Solvents: Methanol1.2 Reagents: Hydrogen Solvents: Methanol; 23 H,20 Bar,50 °C 标题:Highly Enantioselective Synthesis Of 3-Hydroxy-2-Methylpropanoic Acid Esters Through Ruthenium-Synphos-Catalyzed Hydrogenation. Useful Building Blocks For The Synthetic Community 作者:Jeulin,Severine; Et Al 参考文献:Advanced Synthesis & Catalysis 日期:2007 卷标:349(10) 页码:1592-1596]
73295-10-0 = 80657-57-4 反应条件:1.1 Reagents: Potassium Carbonate Solvents: Methanol 标题:Synthesis Of The S-Enantiomer Of Paniculidine A: Absolute R-Configuration Of The Natural Paniculidines A And B 作者:Czeskis,B. A.; Et Al 参考文献:Journal Of The Chemical Society 日期:1989 卷标:(7) 页码:1353-4]
23953-00-6 = 80657-57-4 反应条件:1.1 Reagents: Imidazole,Triphenylphosphine,Iodine Solvents: Diethyl Ether,Acetonitrile 标题:Anomeric C-C Bond Formation Via Sulphones 作者:Brown,Dearg Sutherland 参考文献:1990]
121843-31-0 = 80657-57-4 反应条件:1.1 Reagents: Sodium Borohydride 标题:Preparation Of Chiral C5-Building Blocks For Terpene Synthesis By Bakers' Yeast. Reduction Of Sulfur-Functionalized Prenyl Derivatives 作者:Sato,Toshio; Et Al 参考文献:Tetrahedron Letters 日期:1988 卷标:29(18) 页码:2197-200]
110595-22-7 = 80657-57-4 反应条件:1.1 Reagents: Silica,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Benzene1.2 Solvents: Diethyl Ether2.1 Reagents: Potassium Carbonate Solvents: Methanol 标题:Synthesis Of The S-Enantiomer Of Paniculidine A: Absolute R-Configuration Of The Natural Paniculidines A And B 作者:Czeskis,B. A.; Et Al 参考文献:Journal Of The Chemical Society 日期:1989 卷标:(7) 页码:1353-4]
15484-46-5 = 80657-57-4 反应条件:1.1 Reagents: Hydrogen Catalysts: Rhodium(1+),Bis[(2,3,5,6-η)-Bicyclo[2.2.1]Hepta-2,5-Diene]-,Tetrafluoroborate(...,2-[bis(1-Methylethyl)Phosphino]-1-(11Bs)-Dinaphtho[2,1-D:1′,2′-F][1,3,2]Dioxapho... Solvents: Dichloromethane; 16 H,10 Bar,-40 °C 标题:Asymmetric Hydrogenation With Highly Active Indolphos-Rh Catalysts: Kinetics And Reaction Mechanism 作者:Wassenaar,Jeroen; Et Al 参考文献:Chemistry - A European Journal 日期:2010 卷标:16(22) 页码:6509-6517]
15484-46-5 = 80657-57-4 反应条件:1.1 Reagents: Hydrogen Catalysts: Rhodium(1+),Bis[(2,3,5,6-η)-Bicyclo[2.2.1]Hepta-2,5-Diene]-,Tetrafluoroborate(...,2-[bis(1-Methylethyl)Phosphino]-1-(11Bs)-Dinaphtho[2,1-D:1′,2′-F][1,3,2]Dioxapho... Solvents: Dichloromethane; 15 H,20 Bar,-40 °C 标题:Asymmetric Synthesis Of The Roche Ester And Its Derivatives By Rhodium-Indolphos-Catalyzed Hydrogenation 作者:Wassenaar,Jeroen; Et Al 参考文献:Advanced Synthesis & Catalysis 日期:2008 卷标:350(10) 页码:1610-1614]
74924-27-9 = 80657-57-4 反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium,Carbon,Palladium Dihydroxide Solvents: Isopropanol,Tetrahydrofuran; 6 H,Rt 标题:More Efficient Palladium Catalyst For Hydrogenolysis Of Benzyl Groups 作者:Li,Yong; Et Al 参考文献:Synthetic Communications 日期:2006 卷标:36(7) 页码:925-928]
= 80657-57-4 反应条件:1.1 Reagents: Potassium Carbonate,Potassium Fluoride Solvents: Methanol,Tetrahydrofuran; 0 °C1.2 Reagents: Hydrogen Peroxide Solvents: Water; 0 °C; 0.5 H,0 °C; 3 H,50 °C1.3 Reagents: 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone Solvents: Dichloromethane,Water; 0 °C; 2 H,0 °C; 0 °C -> Rt1.4 Solvents: Water; Rt 标题:New Strategies For Protecting Group Chemistry: Synthesis,Reactivity,And Indirect Oxidative Cleavage Of Para-Siletanylbenzyl Ethers 作者:Tlais,Sami F.; Et Al 参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(5) 页码:1876-1885]
143590-14-1 = 80657-57-4 反应条件:1.1 Reagents: Triethylamine,4-(Dimethylamino)Pyridine Solvents: Acetic Anhydride1.2 Reagents: Sodium Periodate Catalysts: Ruthenium Trichloride Solvents: Carbon Tetrachloride,Acetonitrile,Water1.3 -1.4 Reagents: Potassium Carbonate Solvents: Methanol 标题:Enantioselective Synthesis Of 1,3-Dioxygen-Substituted Chiral Building Blocks 作者:Senanayake,Chris H.; Et Al 参考文献:Synlett 日期:1994 卷标:(3) 页码:199-200]
19141-40-3 = 80657-57-4 反应条件:1.1 Reagents: Triethylamine,4-(Dimethylamino)Pyridine Solvents: Acetic Anhydride1.2 Reagents: Sodium Periodate Catalysts: Ruthenium Trichloride Solvents: Carbon Tetrachloride,Acetonitrile,Water1.3 -1.4 Reagents: Methanol,Potassium Carbonate Solvents: Methanol 标题:Enantioselective Synthesis Of 1,3-Dioxygen-Substituted Chiral Building Blocks 作者:Senanayake,Chris H.; Et Al 参考文献:Synlett 日期:1994 卷标:(3) 页码:199-200]
26543-05-5 = 80657-57-4 反应条件:1.1 Solvents: Diethyl Ether 标题:Enantioselective Processes. Reaction Of Optically Active Amines With Photochemically Generated Ketenes 作者:Schultz,Arthur G.; Et Al 参考文献:Journal Of Organic Chemistry 日期:1984 卷标:49(26) 页码:5202-6]
= 80657-57-4 反应条件:1.1 -2.1 Reagents: Sodium Borohydride 标题:Preparation Of Chiral C5-Building Blocks For Terpene Synthesis By Bakers' Yeast. Reduction Of Sulfur-Functionalized Prenyl Derivatives 作者:Sato,Toshio; Et Al 参考文献:Tetrahedron Letters 日期:1988 卷标:29(18) 页码:2197-200]
专利号:US-7348436-B2 优先权日:2004-03-02 标题 :Compounds useful for the synthesis of (+)-discodermolide and methods thereof 发明人:MYLES DAVID C; SHAW SIMON JAMES; SUNDERMANN KURT F 权利人:KOSAN BIOSCIENCES INC 摘要:Compounds and methods useful for the synthesis of (+)-discodermolide, a naturally occurring microtubule stabilizing agent useful as an anti-cancer agent.
专利号:US-4940797-A 优先权日:1989-03-23 标题:Process for synthesis of FK-506 C10-C18 intermediates 发明人:JONES TODD K; MILLS SANDER G; DESMOND RICHARD 权利人:MERCK & CO INC 摘要:A process is described for the improved synthesis of the optically pure C 10 -C 18 fragment of the macrolide structure of the immunosuppressant FK-506. This compound is also useful as an intermediate for preparing FK-506 derivatives.
专利号:US-6384228-B2 优先权日:1998-05-26 标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof 发明人:NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO 权利人:NIHON MEDIPHYSICS CO LTD 摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.
专利号:US-7339066-B1 优先权日:2006-05-31 标题 :Intermediates for the synthesis of polypropionate antibiotics 发明人:PARKER KATHLYN; CAO HUANYAN 权利人:UNIV NEW YORK STATE RES FOUND 摘要:The invention relates to intermediate compounds of the formula n nwherein R 1 is H or a protecting group, R 2 and R 3 each independently represent H, methyl, or a leaving group, provided that at least one, but not both, of R 2 and R 3 is a leaving group. The intermediate compounds are useful for the synthesis of discodermolide, its derivatives, and related compounds.
专利号:US-5338865-A 优先权日:1992-03-12 标 题 :Synthesis of halichondrin B and norhalichondrin B 发明人:KISHI YOSHITO; FANG FRANCIS; FORSYTH CRAIG J; SCOLA PAULA M; YOON SUK KYOON 权利人:HARVARD COLLEGE 摘要:Novel chemical compounds that can be used to synthesize halichondrin B and norhalichondrin B, and related derivatives, are described. The synthesis of halichondrin B and norhalichondrin B from these compounds also is described.
专利号:US-7321046-B2 优先权日:2002-09-06 标 题 :Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof 发明人:CURRAN DENNIS P; SHIN YOUSEUNG; FOURNIER JEAN-HUGUES; MANCUSO JOHN; DAY BILLY W; BRUCKNER ARNDT; FUKUI YOSHIKAZU 权利人:UNIV PITTSBURGH 摘要:Dictyostatin and its analogs show great promise as new anticancer agents. The present invention provides dictyostatin analogs, synthetic intermediates for the synthesis of dictyostatin analogs, and synthetic methods for the synthesis of such analogs and intermediates. Dictyostatin analogs can have the following structure or its enantiomer n nwherein R 1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R 2 is H, a protecting group, an alkyl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; R a , R b and R c are independently an alkyl group or an aryl group; R d is an alkyl group, an aryl group, an alkoxylalkyl group, —R i SiR a R b R c or a benzyl group, wherein R i is an alkylene group; R e is an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or —NR g R h , wherein R g and R h are independently H, an alkyl group or an aryl group; R 3 is (CH 2 ) n where n is and integer in the range of 0 to 5, —CH 2 CH(CH 3 )—, —CHâ•?CH—, —CHâ•?C(CH 3 )—, or —C≡C—; R 4 isn n nwherein R 23a is H, a protecting group, an alkyl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; R 23b is H, a protecting group, an alkyl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e , or R 23a and R 23b together form a portion of six-membered acetal ring incorporating CR t R u ; R t and R u are independently H, an alkyl group, an aryl group or an alkoxyaryl group; and R 5 is H or OR 2b , wherein R 2b is H, a protecting group, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; provided that the compound is not dictyostatin 1.
参考文献:10.1055/s-2007-967978 摘要:Leahy J, Zylstra E, She M, Salamant W. A Flexible Synthetic Approach to the Hennoxazoles. Synlett. 2007 Feb 21;2007(04):0623–7. doi: 10.1055/s-2007-967978. 参考文献:10.1055/s-0032-1318109 摘要:Ley S, Fernández A, Levine Z, Baumann M, Sulzer-Mossé S, Sparr C, Schläger S, Metzger A, Baxendale I. Synthesis of (-)-Hennoxazole A: Integrating Batch and Flow Chemistry Methods. Synlett. 2013 Jan 30;24(04):514–8. doi: 10.1055/s-0032-1318109. 参考文献:10.1055/s-0031-1290675 摘要:Dudley G, Lisboa M, Jeong-Im J, Jones D. Toward a New Palmerolide Assembly Strategy: Synthesis of C16-C24. Synlett. 2012 May 29;23(10):1493–6. doi: 10.1055/s-0031-1290675. 参考文献:10.1055/s-0035-1561469 摘要:Amat M, Bosch J, Llor N, Guignard G. Synthesis of Fluvirucins and Their Aglycons, the Fluvirucinins. Synthesis. 2016 Jun 23;48(17):2705–20. doi: 10.1055/s-0035-1561469. 参考文献:10.1055/s-0033-1340083 摘要:Sabitha G, Gurumurthy C, Yadav J. Studies toward the Synthesis of Iejimalides A–D: Preparation of the C3–11 and C12–C24 Fragments. Synthesis. 2013 Nov 07;46(01):110–8. doi: 10.1055/s-0033-1340083.