CAS: 87-85-4; Hexamethylbenzene

该化合物是一种芳烃,其特点是带有六个甲基组的苯环;这种化合物在室内温度下是一种无色液体,以其甜味,芳香味闻闻名;六甲基苯在水中不溶解,但在有机溶剂中可溶解,反映其疏水性质;由于存在多种增加分子重量和影响分子间相互作用的甲基组,因此与较简单的碳氢化合物相比,其沸点相对较高;该化合物在正常条件下保持稳定,但可经受典型的芳烃化合物反应,如电动机替代;六甲基苯主要用于有机合成,并在各种化学分析中用作参考化合物;六甲基苯的结构和特性使其在与分子对称法和替代芳香系统行为有关的研究中具有兴趣;在处理该化合物时应采取安全防范措施,因为如果吸入或吸入,可能会对健康造成危害.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

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CAS号503-17-3 2-丁炔 | CAS号67-56-1 甲醇 | CAS号7641-77-2 六甲基杜瓦苯 | CAS号118-74-1 六氯苯 | CAS号75-16-1 甲基溴化镁 | CAS号110-88-3 三聚甲醛 | CAS号700-12-9 五甲基苯 | CAS号928-49-4 3-己炔 | CAS号74-87-3 氯甲烷 | CAS号95-93-2 1,2,4,5-四甲苯 | CAS号526-73-8 1,2,3-三甲苯 | CAS号527-53-7 1,2,3,5-四甲基苯 | CAS号108-88-3 甲苯 | CAS号71-43-2 苯 | CAS号517-60-2 苯六酸 | CAS号17432-38-1 五甲基苯甲醛 | CAS号19936-85-7 acetic acid,(2,... | CAS号29328-77-6 (pentamethylphe...

合成工艺路线路线简述

    二苯基汞 以 Not Given 作为反应溶剂,化学反应生成 六甲基苯
    参考文献:Gmelin Handbuch Der Anorganischen Chemie,Gmelin Handbook: Co: Org.Verb.2,3.1.3.5,Page 152-167
    标题:Gmelin Handbuch Der Anorganischen Chemie,Gmelin Handbook: Co: Org.Verb.2,3.1.3.5,Page 152-167

    海关参考信息

    专利信息


    专利号:US-7230101-B1
    优先权日:2002-08-28
    标 题:Synthesis of methotrexate-containing heterodimeric molecules
    发明人:MURTHI KRISHNA K; SMITH CHASE C
    权利人:GPC BIOTECH INC
    摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

    专利号:US-9012625-B2
    优先权日:2009-04-07
    标 题 :Method for the synthesis of a trisaccharide
    发明人:DÉKANY GYULA; Ã?GOSTON KÃ?ROLY; BAJZA ISTVAN; BOUTET JULIEN; BØJSTRUP MARIE; FANEFJORD METTE; PÉREZ FIGUEROA IGNACIO; HEDEROS MARKUS; HORVATH FERENC; KOVÃ?CS-PÉNZES PIROSKA; KRÖGER LARS; OLSSON JOHAN; RÖHRIG CHRISTOPH; SCHROVEN ANDREAS; VRASIDAS IOANNIS
    权利人:DÉKANY GYULA; Ã?GOSTON KÃ?ROLY; BAJZA ISTVAN; BOUTET JULIEN; BØJSTRUP MARIE; FANEFJORD METTE; PÉREZ FIGUEROA IGNACIO; HEDEROS MARKUS; HORVATH FERENC; KOVÃ?CS-PÉNZES PIROSKA; KRÖGER LARS; OLSSON JOHAN; RÖHRIG CHRISTOPH; SCHROVEN ANDREAS; VRASIDAS IOANNIS; GLYCOM AS
    摘要:The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.

    专利号:US-2003162992-A1
    优先权日:2001-12-14
    标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
    发明人:WATANABE KYOICHI A; DU JINFA
    摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

    专利号:US-7148356-B2
    优先权日:2001-07-13
    标题:Process for the catalytic synthesis of biaryls and polymers from aryl compounds
    发明人:SMITH III MILTON R; MALECZKA ROBERT E
    权利人:UNIV MICHIGAN STATE
    摘要:A process for producing organic substituted aromatic or heteroaromatic compounds including biaryl and biheteroaryl compounds in a two-step reaction. In the first step, the aromatic or heteroaromatic compound is borylated in a reaction comprising a borane or diborane reagent (any boron reagent where the boron reagent contains a B—H, B—B or B—Si bond) and an iridium or rhodium catalytic complex. In the second step, a metal catalyst catalyzes the formation of the organic substituted aromatic or heteroaromatic compound from the borylated compound and an electrophile such as an aryl or organic halide, triflate (OSO 2 CF 3 ), or nonaflate (OSO 2 C 4 F 9 ). The steps in the process can be performed in a single reaction vessel or in separate reaction vessels. The present invention also provides a process for synthesis of complex polyphenylenes starting from halogenated aromatic compounds.

    专利号:US-10005807-B2
    优先权日:2013-04-12
    标题 :Synthesis of sialylated/fucosylated human milk oligosaccharides
    发明人:CHASSAGNE PIERRE; KHANZHIN NIKOLAY; HEDEROS MARKUS JONDELIUS; CHAMPION ELISE; MATWIEJUK MARTIN; DEKANY GYULA
    权利人:GLYCOM AS
    摘要:An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N 3 and —OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH 2) n —NH 2 and —(CH 2) n —N 3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO 3 H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that at least one of R 3 and R 4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

    专利号:US-11306041-B2
    优先权日:2017-03-30
    标 题:Catalytic synthesis of super linear alkenyl arenes using rhodium catalysts
    发明人:SCHINSKI WILLIAM; GOLDMAN ALAN; GUNNOE THOMAS B; WEBSTER-GARDINER MICHAEL S; SCHWARTZ NICHOLE
    权利人:UNIV VIRGINIA PATENT FOUNDATION
    摘要:Catalytic methods for synthesis of super linear alkenyl arenes and alkyl arenes are provided. The methods are capable of synthesizing super linear alkyl and alkenyl arenes from simple arene and olefin starting materials and with high selectivity for linear coupling. Methods are also provided for making a 2,6-dimethylnapthalene (DMN) or 2,6-methylethylnapthalene (MEN).
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    合成参考文献


    参考文献:10.1107/s1600536811011640
    摘要:Gupta G, Therrien B, Kim J. [Bis(2-pyridyl-κN)amine]chlorido(η6-hexamethylbenzene)ruthenium(II) hexafluoridophosphate dichloromethane solvate. Acta Crystallogr E Struct Rep Online. 2011 Apr 07;67(5):m548. doi: 10.1107/s1600536811011640.
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